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    Dyrk1a dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1a [ Mus musculus (house mouse) ]

    Gene ID: 13548, updated on 18-Sep-2018

    Summary

    Official Symbol
    Dyrk1aprovided by MGI
    Official Full Name
    dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1aprovided by MGI
    Primary source
    MGI:MGI:1330299
    See related
    Ensembl:ENSMUSG00000022897 Vega:OTTMUSG00000028435
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mmb; Dyrk; Mnbh; Mp86; Gm10783; D16Ertd272e; D16Ertd493e; 2310043O08Rik
    Expression
    Ubiquitous expression in thymus adult (RPKM 12.2), whole brain E14.5 (RPKM 10.0) and 28 other tissues See more
    Orthologs

    Genomic context

    See Dyrk1a in Genome Data Viewer
    Location:
    16 C4; 16 55.3 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 16 NC_000082.6 (94569455..94695519)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 16 NC_000082.5 (94791813..94917126)

    Chromosome 16 - NC_000082.6Genomic Context describing neighboring genes Neighboring gene phosphatidylinositol glycan anchor biosynthesis, class P Neighboring gene tetratricopeptide repeat domain 3 Neighboring gene predicted gene, 31323 Neighboring gene VPS26 endosomal protein sorting factor C Neighboring gene predicted gene, 41504 Neighboring gene predicted gene, 41507

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC150253, MGC150254

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    actin binding ISO
    Inferred from Sequence Orthology
    more info
     
    cytoskeletal protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    non-membrane spanning protein tyrosine kinase activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein self-association IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein serine/threonine kinase activity IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein serine/threonine/tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein tyrosine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    tau protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    tubulin binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    amyloid-beta formation ISO
    Inferred from Sequence Orthology
    more info
     
    circadian rhythm IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of DNA damage response, signal transduction by p53 class mediator IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of mRNA splicing, via spliceosome IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of microtubule polymerization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    peptidyl-serine phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    peptidyl-serine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    peptidyl-threonine phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    peptidyl-threonine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    peptidyl-tyrosine autophosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    peptidyl-tyrosine autophosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    peptidyl-tyrosine phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    peptidyl-tyrosine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of RNA splicing ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein deacetylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein autophosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of alternative mRNA splicing, via spliceosome ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    colocalizes_with actin filament ISO
    Inferred from Sequence Orthology
    more info
     
    axon IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoskeleton IDA
    Inferred from Direct Assay
    more info
    PubMed 
    colocalizes_with cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
     
    dendrite IDA
    Inferred from Direct Assay
    more info
    PubMed 
    colocalizes_with microtubule ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with neurofilament ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear speck ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    ribonucleoprotein complex IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    dual specificity tyrosine-phosphorylation-regulated kinase 1A
    Names
    dual specificity YAK1-related kinase
    protein kinase minibrain homolog
    NP_001106860.1
    NP_031916.1
    XP_011244396.1
    XP_011244397.1
    XP_011244398.1
    XP_011244400.1
    XP_011244401.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001113389.1NP_001106860.1  dual specificity tyrosine-phosphorylation-regulated kinase 1A isoform 1

      See identical proteins and their annotated locations for NP_001106860.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate 5' non-coding exon, therefore, has a different 5' UTR compared to transcript variant 1. Transcript variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK052390, AK163136, BC129888, CB526389, CX566606
      Consensus CDS
      CCDS28350.1
      UniProtKB/Swiss-Prot
      Q61214
      UniProtKB/TrEMBL
      A1L341, A9C475, Q8C774
      Related
      ENSMUSP00000023614.4, ENSMUST00000023614.4
      Conserved Domains (1) summary
      cd14226
      Location:148484
      PKc_DYRK1; Catalytic domain of the protein kinase, Dual-specificity tYrosine-phosphorylated and -Regulated Kinase 1
    2. NM_001347731.1NP_001334660.1  dual specificity tyrosine-phosphorylation-regulated kinase 1A isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC165271, BC145405, CT030190, CX566606
      UniProtKB/TrEMBL
      A1L341
      Conserved Domains (1) summary
      cd14226
      Location:139475
      PKc_DYRK1; Catalytic domain of the protein kinase, Dual-specificity tYrosine-phosphorylated and -Regulated Kinase 1
    3. NM_007890.2NP_031916.1  dual specificity tyrosine-phosphorylation-regulated kinase 1A isoform 1

      See identical proteins and their annotated locations for NP_031916.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Transcript variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK052390, AK163136, BC129888, BF462682, CD540384, CX566606
      Consensus CDS
      CCDS28350.1
      UniProtKB/Swiss-Prot
      Q61214
      UniProtKB/TrEMBL
      A1L341, A9C475, Q8C774
      Related
      ENSMUSP00000113660.1, OTTMUSP00000035913, ENSMUST00000119878.7, OTTMUST00000070459
      Conserved Domains (1) summary
      cd14226
      Location:148484
      PKc_DYRK1; Catalytic domain of the protein kinase, Dual-specificity tYrosine-phosphorylated and -Regulated Kinase 1

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000082.6 Reference GRCm38.p4 C57BL/6J

      Range
      94569455..94695519
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011246094.2XP_011244396.1  dual specificity tyrosine-phosphorylation-regulated kinase 1A isoform X1

      See identical proteins and their annotated locations for XP_011244396.1

      UniProtKB/Swiss-Prot
      Q61214
      UniProtKB/TrEMBL
      A9C475
      Conserved Domains (1) summary
      cd14226
      Location:148484
      PKc_DYRK1; Catalytic domain of the protein kinase, Dual-specificity tYrosine-phosphorylated and -Regulated Kinase 1
    2. XM_011246096.2XP_011244398.1  dual specificity tyrosine-phosphorylation-regulated kinase 1A isoform X2

      See identical proteins and their annotated locations for XP_011244398.1

      UniProtKB/TrEMBL
      A1L341
      Related
      OTTMUSP00000035914, OTTMUST00000070460
      Conserved Domains (1) summary
      cd14226
      Location:139475
      PKc_DYRK1; Catalytic domain of the protein kinase, Dual-specificity tYrosine-phosphorylated and -Regulated Kinase 1
    3. XM_011246098.2XP_011244400.1  dual specificity tyrosine-phosphorylation-regulated kinase 1A isoform X3

      See identical proteins and their annotated locations for XP_011244400.1

      Conserved Domains (2) summary
      smart00220
      Location:130450
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14226
      Location:119455
      PKc_DYRK1; Catalytic domain of the protein kinase, Dual-specificity tYrosine-phosphorylated and -Regulated Kinase 1
    4. XM_011246099.2XP_011244401.1  dual specificity tyrosine-phosphorylation-regulated kinase 1A isoform X4

      See identical proteins and their annotated locations for XP_011244401.1

      Related
      ENSMUSP00000112853.2, ENSMUST00000122284.8
      Conserved Domains (2) summary
      smart00220
      Location:121441
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14226
      Location:110446
      PKc_DYRK1; Catalytic domain of the protein kinase, Dual-specificity tYrosine-phosphorylated and -Regulated Kinase 1
    5. XM_011246095.2XP_011244397.1  dual specificity tyrosine-phosphorylation-regulated kinase 1A isoform X1

      See identical proteins and their annotated locations for XP_011244397.1

      UniProtKB/Swiss-Prot
      Q61214
      UniProtKB/TrEMBL
      A9C475
      Conserved Domains (1) summary
      cd14226
      Location:148484
      PKc_DYRK1; Catalytic domain of the protein kinase, Dual-specificity tYrosine-phosphorylated and -Regulated Kinase 1

    Reference GRCm38.p4 129S6/SvEvTac

    Genomic

    1. NT_039634.4 Reference GRCm38.p4 129S6/SvEvTac

      Range
      453264..578192
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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