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    Dtnb dystrobrevin, beta [ Mus musculus (house mouse) ]

    Gene ID: 13528, updated on 31-Jan-2019

    Summary

    Official Symbol
    Dtnbprovided by MGI
    Official Full Name
    dystrobrevin, betaprovided by MGI
    Primary source
    MGI:MGI:1203728
    See related
    Ensembl:ENSMUSG00000071454
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Expression
    Ubiquitous expression in testis adult (RPKM 19.5), frontal lobe adult (RPKM 9.3) and 27 other tissues See more
    Orthologs

    Genomic context

    See Dtnb in Genome Data Viewer
    Location:
    12 A1.1; 12 1.88 cM
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 12 NC_000078.6 (3572391..3783938)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 12 NC_000078.5 (3572391..3781398)

    Chromosome 12 - NC_000078.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 31332 Neighboring gene additional sex combs like 2, transcriptional regulator Neighboring gene ribosomal protein S7, pseudogene 2 Neighboring gene 40S ribosomal protein S26-like Neighboring gene 60S ribosomal protein L36a-like Neighboring gene predicted gene, 18028 Neighboring gene DNA methyltransferase 3A Neighboring gene DNA methyltransferase 3A, opposite strand Neighboring gene predicted gene, 31623

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    dystrobrevin beta
    Names
    DTN-B
    beta-dystrobrevin
    mDTN-B

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001162465.2NP_001155937.1  dystrobrevin beta isoform a

      See identical proteins and their annotated locations for NP_001155937.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (a).
      Source sequence(s)
      AC155273, AK043436, CR974568
      Consensus CDS
      CCDS49015.1
      UniProtKB/Swiss-Prot
      O70585
      Related
      ENSMUSP00000126194.2, ENSMUST00000164578.8
      Conserved Domains (4) summary
      cd02334
      Location:241289
      ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
      pfam09068
      Location:16140
      EF-hand_2; EF hand
      pfam09069
      Location:144232
      EF-hand_3; EF-hand
      cl23720
      Location:442522
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
    2. NM_001355528.1NP_001342457.1  dystrobrevin beta isoform c

      Status: VALIDATED

      Source sequence(s)
      AC155273, CR974568
      Conserved Domains (3) summary
      cd02334
      Location:241289
      ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
      cd16244
      Location:54214
      EFh_DTN; EF-hand-like motif found in dystrobrevins and similar proteins
      cl25732
      Location:407497
      SMC_N; RecF/RecN/SMC N terminal domain
    3. NM_007886.3NP_031912.2  dystrobrevin beta isoform b

      See identical proteins and their annotated locations for NP_031912.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and contains an alternate exon in the 3' coding region, which results in a frameshift and an early stop codon compared to variant 1. The encoded isoform (b) is shorter and has a distinct C-terminus compared to isoform a.
      Source sequence(s)
      AC155273, AK043436, CR974568
      Consensus CDS
      CCDS36396.2
      UniProtKB/TrEMBL
      Q8K0N0
      Related
      ENSMUSP00000077085.6, ENSMUST00000077930.12
      Conserved Domains (4) summary
      cd02334
      Location:241289
      ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
      pfam09068
      Location:16140
      EF-hand_2; EF hand
      pfam09069
      Location:144232
      EF-hand_3; EF-hand
      cl23720
      Location:442522
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

    RNA

    1. NR_027869.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) contains three alternate internal exons, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC155273, AK043436, BQ173934, CR974568
      Related
      ENSMUST00000101637.10
    2. NR_027870.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) contains two alternate internal exons, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC155273, AK043436, CR974568
      Related
      ENSMUST00000164607.8
    3. NR_149729.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC155273, CR974568

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000078.6 Reference GRCm38.p4 C57BL/6J

      Range
      3572391..3783938
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011243814.2XP_011242116.1  dystrobrevin beta isoform X6

      Conserved Domains (4) summary
      cd02334
      Location:241289
      ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
      pfam09068
      Location:16140
      EF-hand_2; EF hand
      pfam09069
      Location:144232
      EF-hand_3; EF-hand
      cl23720
      Location:442522
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
    2. XM_006514959.3XP_006515022.1  dystrobrevin beta isoform X5

      See identical proteins and their annotated locations for XP_006515022.1

      UniProtKB/TrEMBL
      Q8K0N0
      Conserved Domains (4) summary
      cd02334
      Location:241289
      ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
      pfam09068
      Location:16140
      EF-hand_2; EF hand
      pfam09069
      Location:144232
      EF-hand_3; EF-hand
      cl23720
      Location:442522
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
    3. XM_011243813.2XP_011242115.1  dystrobrevin beta isoform X1

      Conserved Domains (4) summary
      cd02334
      Location:241289
      ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
      pfam09068
      Location:16140
      EF-hand_2; EF hand
      pfam09069
      Location:144232
      EF-hand_3; EF-hand
      cl23720
      Location:442531
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
    4. XM_006514958.3XP_006515021.1  dystrobrevin beta isoform X3

      UniProtKB/TrEMBL
      G3UZ87
      Related
      ENSMUSP00000134392.1, ENSMUST00000173199.7
      Conserved Domains (4) summary
      cd02334
      Location:241289
      ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
      pfam09068
      Location:16140
      EF-hand_2; EF hand
      pfam09069
      Location:144232
      EF-hand_3; EF-hand
      cl23720
      Location:442531
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
    5. XM_006514960.3XP_006515023.1  dystrobrevin beta isoform X7

      Conserved Domains (4) summary
      cd02334
      Location:241289
      ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
      pfam09068
      Location:16140
      EF-hand_2; EF hand
      pfam09069
      Location:144232
      EF-hand_3; EF-hand
      cl23720
      Location:442531
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
    6. XM_006514961.3XP_006515024.1  dystrobrevin beta isoform X8

      Related
      ENSMUSP00000133927.1, ENSMUST00000174547.7
      Conserved Domains (4) summary
      cd02334
      Location:241289
      ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
      pfam09068
      Location:16140
      EF-hand_2; EF hand
      pfam09069
      Location:144232
      EF-hand_3; EF-hand
      cl23720
      Location:442531
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
    7. XM_017314954.1XP_017170443.1  dystrobrevin beta isoform X9

    8. XM_017314952.1XP_017170441.1  dystrobrevin beta isoform X2

    9. XM_017314957.1XP_017170446.1  dystrobrevin beta isoform X11

      Related
      ENSMUSP00000133722.1, ENSMUST00000173240.7
      Conserved Domains (3) summary
      cd02334
      Location:241289
      ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
      cd16244
      Location:54214
      EFh_DTN; EF-hand-like motif found in dystrobrevins and similar proteins
      cl25732
      Location:407497
      SMC_N; RecF/RecN/SMC N terminal domain
    10. XM_017314953.1XP_017170442.1  dystrobrevin beta isoform X4

    11. XM_017314955.1XP_017170444.1  dystrobrevin beta isoform X10

    12. XM_017314958.1XP_017170447.1  dystrobrevin beta isoform X12

    13. XM_017314956.1XP_017170445.1  dystrobrevin beta isoform X10

    14. XM_017314951.1XP_017170440.1  dystrobrevin beta isoform X1

      Conserved Domains (4) summary
      cd02334
      Location:241289
      ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
      pfam09068
      Location:16140
      EF-hand_2; EF hand
      pfam09069
      Location:144232
      EF-hand_3; EF-hand
      cl23720
      Location:442531
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
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