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    Slc26a2 solute carrier family 26 (sulfate transporter), member 2 [ Mus musculus (house mouse) ]

    Gene ID: 13521, updated on 18-Sep-2024

    Summary

    Official Symbol
    Slc26a2provided by MGI
    Official Full Name
    solute carrier family 26 (sulfate transporter), member 2provided by MGI
    Primary source
    MGI:MGI:892977
    See related
    Ensembl:ENSMUSG00000034320 AllianceGenome:MGI:892977
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Dtd; ST-OB
    Summary
    Predicted to enable anion transmembrane transporter activity. Predicted to be involved in ossification and sulfate transmembrane transport. Predicted to be located in apical plasma membrane and microvillus membrane. Predicted to be integral component of plasma membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; sensory organ; and skeleton. Used to study diastrophic dysplasia. Human ortholog(s) of this gene implicated in bone disease (multiple). Orthologous to human SLC26A2 (solute carrier family 26 member 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in colon adult (RPKM 28.9), large intestine adult (RPKM 11.3) and 13 other tissues See more
    Orthologs
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    Genomic context

    See Slc26a2 in Genome Data Viewer
    Location:
    18 E1; 18 34.41 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (61329926..61344668, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (61196854..61211596, complement)

    Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene HMG box domain containing 3 Neighboring gene predicted gene, 26403 Neighboring gene predicted gene, 50614 Neighboring gene STARR-positive B cell enhancer ABC_E7591 Neighboring gene STARR-seq mESC enhancer starr_44740 Neighboring gene predicted gene, 52353 Neighboring gene phosphodiesterase 6A, cGMP-specific, rod, alpha Neighboring gene STARR-seq mESC enhancer starr_44743 Neighboring gene ribosomal protein S2, pseudogene 10 Neighboring gene STARR-seq mESC enhancer starr_44744 Neighboring gene peroxisome proliferative activated receptor, gamma, coactivator 1 beta Neighboring gene predicted gene, 46627

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (2)  1 citation

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables bicarbonate transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables chloride transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables oxalate transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables secondary active sulfate transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables solute:inorganic anion antiporter activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables solute:inorganic anion antiporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables sulfate transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables sulfate transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables sulfate transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables sulfate transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in chloride transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in chondrocyte differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in chondrocyte proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in ossification IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in ossification ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in sulfate transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in sulfate transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in sulfate transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in sulfate transmembrane transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in apical plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in apical plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in microvillus membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in microvillus membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    sulfate transporter
    Names
    diastrophic dysplasia protein homolog
    solute carrier family 26 member 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_007885.2NP_031911.1  sulfate transporter

      Status: VALIDATED

      Source sequence(s)
      AC148012, AK052942
      Consensus CDS
      CCDS29282.1
      UniProtKB/Swiss-Prot
      Q543D6, Q62273, Q8R2L9
      Related
      ENSMUSP00000119447.2, ENSMUST00000146409.8
      Conserved Domains (2) summary
      TIGR00815
      Location:94715
      sulP; high affinity sulphate transporter 1
      cl00604
      Location:570707
      STAS; Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000084.7 Reference GRCm39 C57BL/6J

      Range
      61329926..61344668 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)