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    Dpm2 dolichol-phosphate (beta-D) mannosyltransferase 2 [ Mus musculus (house mouse) ]

    Gene ID: 13481, updated on 23-Jun-2021

    Summary

    Official Symbol
    Dpm2provided by MGI
    Official Full Name
    dolichol-phosphate (beta-D) mannosyltransferase 2provided by MGI
    Primary source
    MGI:MGI:1330238
    See related
    Ensembl:ENSMUSG00000026810
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    R75484; AW557993
    Expression
    Ubiquitous expression in adrenal adult (RPKM 57.3), large intestine adult (RPKM 53.3) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Dpm2 in Genome Data Viewer
    Location:
    2; 2 B
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (32460870..32463583)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (32570858..32573571)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (32426378..32429091)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 25 Neighboring gene nuclear apoptosis inducing factor 1 Neighboring gene family with sequence similarity 102, member A Neighboring gene RIKEN cDNA 9430097D07 gene Neighboring gene phosphatidylinositol-4-phosphate 5-kinase-like 1 Neighboring gene ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4 Neighboring gene predicted gene, 52551 Neighboring gene predicted gene, 23369

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables dolichyl-phosphate beta-D-mannosyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    enables enzyme activator activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables enzyme regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables enzyme regulator activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in GPI anchor biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within GPI anchor biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    involved_in GPI anchor biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within dolichol metabolic process ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    involved_in regulation of protein stability ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    part_of dolichol-phosphate-mannose synthase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of dolichol-phosphate-mannose synthase complex ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    colocalizes_with endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    part_of glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in integral component of endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in integral component of membrane ISM
    Inferred from Sequence Model
    more info
    PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    dolichol phosphate-mannose biosynthesis regulatory protein
    Names
    DPM synthase subunit 2
    dolichol-phosphate mannose synthase subunit 2
    NP_034203.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_010073.2NP_034203.1  dolichol phosphate-mannose biosynthesis regulatory protein

      See identical proteins and their annotated locations for NP_034203.1

      Status: VALIDATED

      Source sequence(s)
      BC008256
      Consensus CDS
      CCDS38104.1
      UniProtKB/Swiss-Prot
      Q9Z324
      UniProtKB/TrEMBL
      Q545R7
      Related
      ENSMUSP00000028151.7, ENSMUST00000028151.7
      Conserved Domains (1) summary
      pfam07297
      Location:578
      DPM2; Dolichol phosphate-mannose biosynthesis regulatory protein (DPM2)

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      32460870..32463583
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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