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    LSM11 LSM11, U7 small nuclear RNA associated [ Homo sapiens (human) ]

    Gene ID: 134353, updated on 27-Nov-2024

    Summary

    Official Symbol
    LSM11provided by HGNC
    Official Full Name
    LSM11, U7 small nuclear RNA associatedprovided by HGNC
    Primary source
    HGNC:HGNC:30860
    See related
    Ensembl:ENSG00000155858 MIM:617910; AllianceGenome:HGNC:30860
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    AGS8
    Summary
    Enables U7 snRNA binding activity. Involved in mRNA 3'-end processing by stem-loop binding activity and cleavage; positive regulation of G1/S transition of mitotic cell cycle; and regulation of chromatin organization. Located in nuclear body. Part of U7 snRNP and telomerase holoenzyme complex. Implicated in Aicardi-Goutieres syndrome. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in brain (RPKM 3.6), testis (RPKM 3.3) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See LSM11 in Genome Data Viewer
    Location:
    5q33.3
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (157743712..157760709)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (158262719..158279702)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (157170720..157187717)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105377676 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23529 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23530 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23531 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16563 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:157171083-157171583 Neighboring gene tRNA-histidine guanylyltransferase 1 like Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16564 Neighboring gene clathrin interactor 1 Neighboring gene RNA, U6 small nuclear 260, pseudogene Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:157285783-157286364 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr5:157308515-157309160 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16565 Neighboring gene ReSE screen-validated silencer GRCh37_chr5:157346675-157346817 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:157353623-157354424 Neighboring gene ribosomal protein lateral stalk subunit P2 pseudogene 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ13097, FLJ30735, FLJ38273, FLJ41957, FLJ42254

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables U7 snRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables U7 snRNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables U7 snRNA binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of U7 snRNP IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of U7 snRNP IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of U7 snRNP ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    part_of histone pre-mRNA 3'end processing complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in nuclear body IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of telomerase holoenzyme complex IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    U7 snRNA-associated Sm-like protein LSm11

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_173491.4NP_775762.1  U7 snRNA-associated Sm-like protein LSm11

      See identical proteins and their annotated locations for NP_775762.1

      Status: VALIDATED

      Source sequence(s)
      AC026407, AI271367, BC051353, BC126449
      Consensus CDS
      CCDS4342.1
      UniProtKB/Swiss-Prot
      A0AVQ1, P83369, Q7Z7P0, Q8N975
      Related
      ENSP00000286307.5, ENST00000286307.6
      Conserved Domains (1) summary
      cd01739
      Location:159224
      LSm11_M; Like-Sm protein 11, middle domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

      Range
      157743712..157760709
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060929.1 Alternate T2T-CHM13v2.0

      Range
      158262719..158279702
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)