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    Dnajc1 DnaJ heat shock protein family (Hsp40) member C1 [ Mus musculus (house mouse) ]

    Gene ID: 13418, updated on 31-Jan-2019

    Summary

    Official Symbol
    Dnajc1provided by MGI
    Official Full Name
    DnaJ heat shock protein family (Hsp40) member C1provided by MGI
    Primary source
    MGI:MGI:103268
    See related
    Ensembl:ENSMUSG00000026740
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    MTJ1; ERdj1; ERj1p; Dnajl1; AA960110; 4733401K02Rik; D230036H06Rik
    Expression
    Ubiquitous expression in testis adult (RPKM 10.4), thymus adult (RPKM 9.4) and 28 other tissues See more
    Orthologs

    Genomic context

    See Dnajc1 in Genome Data Viewer
    Location:
    2; 2 A3
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 2 NC_000068.7 (18206333..18392853, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (18138762..18314134, complement)

    Chromosome 2 - NC_000068.7Genomic Context describing neighboring genes Neighboring gene myeloid/lymphoid or mixed-lineage leukemia; translocated to, 10 Neighboring gene heterogeneous nuclear ribonucleoprotein A3 pseudogene Neighboring gene predicted gene, 39761 Neighboring gene GAR1 ribonucleoprotein homolog pseudogene Neighboring gene nuclear encoded tRNA asparagine 9 (anticodon GTT) Neighboring gene aminoadipate-semialdehyde dehydrogenase pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Pathways from BioSystems

    • Protein processing in endoplasmic reticulum, organism-specific biosystem (from KEGG)
      Protein processing in endoplasmic reticulum, organism-specific biosystemThe endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylate...
    • Protein processing in endoplasmic reticulum, conserved biosystem (from KEGG)
      Protein processing in endoplasmic reticulum, conserved biosystemThe endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylate...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    chaperone binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    ribosome binding TAS
    Traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    protein folding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of protein secretion ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of translation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 
    endoplasmic reticulum lumen TAS
    Traceable Author Statement
    more info
    PubMed 
    integral component of membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    intracellular membrane-bounded organelle IEA
    Inferred from Electronic Annotation
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    nucleus TAS
    Traceable Author Statement
    more info
    PubMed 
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    dnaJ homolog subfamily C member 1
    Names
    DnaJ (Hsp40) homolog, subfamily C, member 1
    DnaJ-like protein 1
    dnaJ protein homolog MTJ1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001190817.1NP_001177746.1  dnaJ homolog subfamily C member 1 precursor

      See identical proteins and their annotated locations for NP_001177746.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 3' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AL845265, BC080300
      Consensus CDS
      CCDS15709.1
      UniProtKB/Swiss-Prot
      Q61712
      Related
      ENSMUSP00000088980.5, ENSMUST00000091418.11
      Conserved Domains (3) summary
      smart00717
      Location:493542
      SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
      cd00167
      Location:494541
      SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
      pfam00226
      Location:61122
      DnaJ; DnaJ domain
    2. NM_007869.3NP_031895.1  dnaJ homolog subfamily C member 1 precursor

      See identical proteins and their annotated locations for NP_031895.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AL845265, AL928557, L16953
      Consensus CDS
      CCDS15709.1
      UniProtKB/Swiss-Prot
      Q61712
      Related
      ENSMUSP00000126321.1, ENSMUST00000166495.7
      Conserved Domains (3) summary
      smart00717
      Location:493542
      SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
      cd00167
      Location:494541
      SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
      pfam00226
      Location:61122
      DnaJ; DnaJ domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000068.7 Reference GRCm38.p4 C57BL/6J

      Range
      18206333..18392853 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011238947.1XP_011237249.1  dnaJ homolog subfamily C member 1 isoform X1

      Conserved Domains (2) summary
      smart00717
      Location:243292
      SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
      cd00167
      Location:244291
      SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...

    RNA

    1. XR_865923.2 RNA Sequence

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