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    Dlg1 discs large MAGUK scaffold protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 13383, updated on 5-Sep-2021

    Summary

    Official Symbol
    Dlg1provided by MGI
    Official Full Name
    discs large MAGUK scaffold protein 1provided by MGI
    Primary source
    MGI:MGI:107231
    See related
    Ensembl:ENSMUSG00000022770
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    SA; Dlgh; Dlgh1; SAP97; SAP-97; mKIAA4187; E-dlg/SAP97; B130052P05Rik
    Expression
    Ubiquitous expression in cortex adult (RPKM 13.3), bladder adult (RPKM 13.0) and 28 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Dlg1 in Genome Data Viewer
    Location:
    16 B2; 16 22.4 cM
    Exon count:
    31
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (31482261..31692174)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (31663443..31873356)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 16 NC_000082.5 (31664125..31873432)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA48 Neighboring gene predicted gene 536 Neighboring gene predicted gene, 24879 Neighboring gene nucleoporin 37 pseudogene Neighboring gene melanotransferrin Neighboring gene predicted gene, 52243 Neighboring gene predicted gene, 34476

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • KIAA4187

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables L27 domain binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables PDZ domain binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables ionotropic glutamate receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables kinase binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    enables kinesin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables mitogen-activated protein kinase kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables molecular adaptor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables phosphatase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables potassium channel regulator activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables potassium channel regulator activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein C-terminus binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables structural constituent of postsynaptic density IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables structural constituent of postsynaptic density IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables transmembrane transporter binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within T cell activation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within T cell cytokine production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in actin filament organization ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within activation of protein kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within amyloid precursor protein metabolic process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in astral microtubule organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in bicellular tight junction assembly ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within branching involved in ureteric bud morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cell-cell adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in cell-cell adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular protein-containing complex localization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in chemical synaptic transmission IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in cortical actin cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cortical microtubule organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in embryo development IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within embryonic skeletal system morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in endothelial cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in establishment of centrosome localization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in establishment or maintenance of epithelial cell apical/basal polarity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within hard palate development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within immunological synapse formation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within lens development in camera-type eye IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within membrane raft organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of ERK1 and ERK2 cascade ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of G1/S transition of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of T cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of epithelial cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of p38MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of protein kinase B signaling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in neurotransmitter receptor localization to postsynaptic specialization membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in neurotransmitter receptor localization to postsynaptic specialization membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in neurotransmitter receptor localization to postsynaptic specialization membrane IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in neurotransmitter receptor localization to postsynaptic specialization membrane IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in neurotransmitter receptor localization to postsynaptic specialization membrane ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within peristalsis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of actin filament polymerization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of cell population proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of developmental growth TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in positive regulation of multicellular organism growth TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in positive regulation of potassium ion transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein localization to plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within protein localization IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within protein localization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein localization to plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in receptor clustering IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in receptor localization to synapse IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in regulation of cell shape ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of membrane potential IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in regulation of membrane potential ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of myelination IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of potassium ion export across plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of potassium ion import IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of protein localization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of protein localization to synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of protein localization to synapse ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of ventricular cardiac muscle cell action potential IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within reproductive structure development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within smooth muscle tissue development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within tissue morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within ureteric bud development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    part_of MPP7-DLG1-LIN7 complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in T-tubule ISO
    Inferred from Sequence Orthology
    more info
     
    located_in adherens junction TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in basal plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in basement membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in basolateral plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in basolateral plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in basolateral plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in basolateral plasma membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in bicellular tight junction ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cell junction IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cell junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cell junction ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell projection membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cell-cell junction ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasmic side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in dendrite ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in glutamatergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in immunological synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in immunological synapse ISO
    Inferred from Sequence Orthology
    more info
     
    located_in lateral loop IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in lateral plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in lateral plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in membrane raft IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in microtubule ISO
    Inferred from Sequence Orthology
    more info
     
    located_in microvillus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in myelin sheath abaxonal region IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in neuromuscular junction IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in neuromuscular junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in neuron projection IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in neuron projection ISO
    Inferred from Sequence Orthology
    more info
     
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in node of Ranvier IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in paranode region of axon ISO
    Inferred from Sequence Orthology
    more info
     
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     
    located_in postsynaptic density IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in postsynaptic density ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in postsynaptic density membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in presynaptic membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in synaptic membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in synaptic membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in synaptic vesicle membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    disks large homolog 1
    Names
    discs, large homolog 1
    embryo-dlg/synapse-associated protein 97

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001252433.1NP_001239362.1  disks large homolog 1 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an exon and uses an alternate splice site in the coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AC129214, AY159380, BU058018
      UniProtKB/Swiss-Prot
      Q811D0
      Conserved Domains (8) summary
      cd12031
      Location:549615
      SH3_DLG1; Src Homology 3 domain of Disks Large homolog 1
      smart00072
      Location:713880
      GuKc; Guanylate kinase homologues
      smart00228
      Location:430514
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00992
      Location:191275
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00625
      Location:702880
      Guanylate_kin; Guanylate kinase
      pfam09058
      Location:462
      L27_1; L27_1
      pfam10600
      Location:371432
      PDZ_assoc; PDZ-associated domain of NMDA receptors
      pfam10608
      Location:106190
      MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK
    2. NM_001252434.1NP_001239363.1  disks large homolog 1 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks two exons and includes an alternate exon in the coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (3) is shorter than isoform 1.
      Source sequence(s)
      AC129214, AK143780, AY159380, BU058018
      Consensus CDS
      CCDS57026.1
      UniProtKB/Swiss-Prot
      Q811D0
      UniProtKB/TrEMBL
      H7BWY4, Q3UP61
      Related
      ENSMUSP00000023454.6, ENSMUST00000023454.12
      Conserved Domains (8) summary
      cd12031
      Location:549615
      SH3_DLG1; Src Homology 3 domain of Disks Large homolog 1
      smart00072
      Location:692859
      GuKc; Guanylate kinase homologues
      smart00228
      Location:430514
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00992
      Location:191275
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00625
      Location:681859
      Guanylate_kin; Guanylate kinase
      pfam09058
      Location:462
      L27_1; L27_1
      pfam10600
      Location:371432
      PDZ_assoc; PDZ-associated domain of NMDA receptors
      pfam10608
      Location:106190
      MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK
    3. NM_001252435.1NP_001239364.1  disks large homolog 1 isoform 4

      See identical proteins and their annotated locations for NP_001239364.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR, lacks an exon and includes an alternate exon in the coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (4) is shorter than isoform 1.
      Source sequence(s)
      AC126055, AC129214
      Consensus CDS
      CCDS57025.1
      UniProtKB/Swiss-Prot
      Q811D0
      Related
      ENSMUSP00000110859.2, ENSMUST00000115205.9
      Conserved Domains (7) summary
      cd12031
      Location:582648
      SH3_DLG1; Src Homology 3 domain of Disks Large homolog 1
      smart00228
      Location:463547
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00992
      Location:224308
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00625
      Location:714892
      Guanylate_kin; Guanylate kinase
      pfam09058
      Location:262
      L27_1
      pfam10600
      Location:404465
      PDZ_assoc; PDZ-associated domain of NMDA receptors
      pfam10608
      Location:106223
      MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK
    4. NM_001252436.1NP_001239365.1  disks large homolog 1 isoform 5

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR and has multiple differences in the coding region, including the use of an alternate start codon, compared to variant 1. The encoded isoform (5) is shorter and has a distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AC129214, AK142893, CF164686
      Consensus CDS
      CCDS57027.1
      UniProtKB/TrEMBL
      D3Z3B8
      Related
      ENSMUSP00000110850.2, ENSMUST00000115196.8
      Conserved Domains (7) summary
      cd12031
      Location:499565
      SH3_DLG1; Src Homology 3 domain of Disks Large homolog 1
      smart00072
      Location:654821
      GuKc; Guanylate kinase homologues
      smart00228
      Location:380464
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00992
      Location:141225
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00625
      Location:643821
      Guanylate_kin; Guanylate kinase
      pfam10600
      Location:321382
      PDZ_assoc; PDZ-associated domain of NMDA receptors
      pfam10608
      Location:107140
      MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK
    5. NM_001357281.1NP_001344210.1  disks large homolog 1 isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC126055, AC129214
      Conserved Domains (6) summary
      cd12031
      Location:453519
      SH3_DLG1; Src Homology 3 domain of Disks Large homolog 1
      smart00228
      Location:334418
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00992
      Location:95179
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00625
      Location:592770
      Guanylate_kin; Guanylate kinase
      pfam10600
      Location:275336
      PDZ_assoc; PDZ-associated domain of NMDA receptors
      pfam10608
      Location:1094
      MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK
    6. NM_001357282.1NP_001344211.1  disks large homolog 1 isoform 8

      Status: VALIDATED

      Source sequence(s)
      AC126055, AC129214
      Conserved Domains (7) summary
      cd12031
      Location:549615
      SH3_DLG1; Src Homology 3 domain of Disks Large homolog 1
      smart00228
      Location:430514
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00992
      Location:191275
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00625
      Location:688866
      Guanylate_kin; Guanylate kinase
      pfam09058
      Location:462
      L27_1; L27_1
      pfam10600
      Location:371432
      PDZ_assoc; PDZ-associated domain of NMDA receptors
      pfam10608
      Location:106190
      MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK
    7. NM_007862.3NP_031888.2  disks large homolog 1 isoform 1

      See identical proteins and their annotated locations for NP_031888.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC129214, BC057118, BU058018
      Consensus CDS
      CCDS28107.1
      UniProtKB/Swiss-Prot
      Q811D0
      Related
      ENSMUSP00000064280.8, ENSMUST00000064477.14
      Conserved Domains (8) summary
      cd12031
      Location:582648
      SH3_DLG1; Src Homology 3 domain of Disks Large homolog 1
      smart00072
      Location:747914
      GuKc; Guanylate kinase homologues
      smart00228
      Location:463547
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00992
      Location:224308
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00625
      Location:736914
      Guanylate_kin; Guanylate kinase
      pfam09058
      Location:462
      L27_1; L27_1
      pfam10600
      Location:404465
      PDZ_assoc; PDZ-associated domain of NMDA receptors
      pfam10608
      Location:106223
      MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK

    RNA

    1. NR_045516.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) lacks two exons, includes an alternate exon, and uses an alternate internal splice site, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC129214, AK220189, BU058018
      Related
      ENSMUST00000132176.8

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      31482261..31692174
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006521761.4XP_006521824.1  disks large homolog 1 isoform X1

      Conserved Domains (7) summary
      cd12031
      Location:582648
      SH3_DLG1; Src Homology 3 domain of Disks Large homolog 1
      smart00228
      Location:463547
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00992
      Location:224308
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00625
      Location:748926
      Guanylate_kin; Guanylate kinase
      pfam09058
      Location:262
      L27_1
      pfam10600
      Location:404465
      PDZ_assoc; PDZ-associated domain of NMDA receptors
      pfam10608
      Location:106223
      MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK
    2. XM_006521763.4XP_006521826.1  disks large homolog 1 isoform X3

      Conserved Domains (7) summary
      cd12031
      Location:582648
      SH3_DLG1; Src Homology 3 domain of Disks Large homolog 1
      smart00228
      Location:463547
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00992
      Location:224308
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00625
      Location:743921
      Guanylate_kin; Guanylate kinase
      pfam09058
      Location:262
      L27_1
      pfam10600
      Location:404465
      PDZ_assoc; PDZ-associated domain of NMDA receptors
      pfam10608
      Location:106223
      MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK
    3. XM_006521762.4XP_006521825.1  disks large homolog 1 isoform X2

      Conserved Domains (7) summary
      cd12031
      Location:582648
      SH3_DLG1; Src Homology 3 domain of Disks Large homolog 1
      smart00228
      Location:463547
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00992
      Location:224308
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00625
      Location:747925
      Guanylate_kin; Guanylate kinase
      pfam09058
      Location:262
      L27_1
      pfam10600
      Location:404465
      PDZ_assoc; PDZ-associated domain of NMDA receptors
      pfam10608
      Location:106223
      MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK
    4. XM_017316865.2XP_017172354.1  disks large homolog 1 isoform X4

      Conserved Domains (7) summary
      cd12031
      Location:582648
      SH3_DLG1; Src Homology 3 domain of Disks Large homolog 1
      smart00228
      Location:463547
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00992
      Location:224308
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00625
      Location:735913
      Guanylate_kin; Guanylate kinase
      pfam09058
      Location:262
      L27_1
      pfam10600
      Location:404465
      PDZ_assoc; PDZ-associated domain of NMDA receptors
      pfam10608
      Location:106223
      MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK
    5. XM_006521765.4XP_006521828.1  disks large homolog 1 isoform X6

      Conserved Domains (7) summary
      cd12031
      Location:582648
      SH3_DLG1; Src Homology 3 domain of Disks Large homolog 1
      smart00228
      Location:463547
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00992
      Location:224308
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00625
      Location:726904
      Guanylate_kin; Guanylate kinase
      pfam09058
      Location:262
      L27_1
      pfam10600
      Location:404465
      PDZ_assoc; PDZ-associated domain of NMDA receptors
      pfam10608
      Location:106223
      MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK
    6. XM_006521766.4XP_006521829.1  disks large homolog 1 isoform X8

      UniProtKB/TrEMBL
      E9Q9H0
      Related
      ENSMUSP00000110855.2, ENSMUST00000115201.8
      Conserved Domains (7) summary
      cd12031
      Location:582648
      SH3_DLG1; Src Homology 3 domain of Disks Large homolog 1
      smart00228
      Location:463547
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00992
      Location:224308
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00625
      Location:721899
      Guanylate_kin; Guanylate kinase
      pfam09058
      Location:262
      L27_1
      pfam10600
      Location:404465
      PDZ_assoc; PDZ-associated domain of NMDA receptors
      pfam10608
      Location:106223
      MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK
    7. XM_006521768.4XP_006521831.1  disks large homolog 1 isoform X10

      See identical proteins and their annotated locations for XP_006521831.1

      UniProtKB/Swiss-Prot
      Q811D0
      Related
      ENSMUSP00000097581.4, ENSMUST00000100001.10
      Conserved Domains (7) summary
      cd12031
      Location:582648
      SH3_DLG1; Src Homology 3 domain of Disks Large homolog 1
      smart00228
      Location:463547
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00992
      Location:224308
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00625
      Location:714892
      Guanylate_kin; Guanylate kinase
      pfam09058
      Location:262
      L27_1
      pfam10600
      Location:404465
      PDZ_assoc; PDZ-associated domain of NMDA receptors
      pfam10608
      Location:106223
      MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK
    8. XM_006521764.5XP_006521827.1  disks large homolog 1 isoform X5

      Conserved Domains (7) summary
      cd12031
      Location:567633
      SH3_DLG1; Src Homology 3 domain of Disks Large homolog 1
      smart00228
      Location:448532
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00992
      Location:224308
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00625
      Location:733911
      Guanylate_kin; Guanylate kinase
      pfam09058
      Location:262
      L27_1
      pfam10600
      Location:406450
      PDZ_assoc; PDZ-associated domain of NMDA receptors
      pfam10608
      Location:106223
      MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK
    9. XM_036159767.1XP_036015660.1  disks large homolog 1 isoform X7

      Conserved Domains (7) summary
      cd12031
      Location:567633
      SH3_DLG1; Src Homology 3 domain of Disks Large homolog 1
      smart00228
      Location:448532
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00992
      Location:224308
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00625
      Location:721899
      Guanylate_kin; Guanylate kinase
      pfam09058
      Location:262
      L27_1
      pfam10600
      Location:406450
      PDZ_assoc; PDZ-associated domain of NMDA receptors
      pfam10608
      Location:106223
      MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK
    10. XM_006521767.5XP_006521830.1  disks large homolog 1 isoform X9

      Conserved Domains (7) summary
      cd12031
      Location:549615
      SH3_DLG1; Src Homology 3 domain of Disks Large homolog 1
      smart00228
      Location:430514
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00992
      Location:191275
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00625
      Location:715893
      Guanylate_kin; Guanylate kinase
      pfam09058
      Location:262
      L27_1
      pfam10600
      Location:371432
      PDZ_assoc; PDZ-associated domain of NMDA receptors
      pfam10608
      Location:106190
      MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK
    11. XM_030248959.2XP_030104819.1  disks large homolog 1 isoform X11

      Conserved Domains (7) summary
      cd12031
      Location:549615
      SH3_DLG1; Src Homology 3 domain of Disks Large homolog 1
      smart00228
      Location:430514
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00992
      Location:191275
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00625
      Location:703881
      Guanylate_kin; Guanylate kinase
      pfam09058
      Location:262
      L27_1
      pfam10600
      Location:371432
      PDZ_assoc; PDZ-associated domain of NMDA receptors
      pfam10608
      Location:106190
      MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK
    12. XM_030248960.2XP_030104820.1  disks large homolog 1 isoform X12

      Conserved Domains (7) summary
      cd12031
      Location:549615
      SH3_DLG1; Src Homology 3 domain of Disks Large homolog 1
      smart00228
      Location:430514
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00992
      Location:191275
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00625
      Location:693871
      Guanylate_kin; Guanylate kinase
      pfam09058
      Location:262
      L27_1
      pfam10600
      Location:371432
      PDZ_assoc; PDZ-associated domain of NMDA receptors
      pfam10608
      Location:106190
      MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK
    13. XM_017316872.1XP_017172361.1  disks large homolog 1 isoform X25

      Conserved Domains (7) summary
      cd12031
      Location:534600
      SH3_DLG1; Src Homology 3 domain of Disks Large homolog 1
      smart00228
      Location:415499
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00992
      Location:191275
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00625
      Location:700878
      Guanylate_kin; Guanylate kinase
      pfam09058
      Location:262
      L27_1
      pfam10600
      Location:373417
      PDZ_assoc; PDZ-associated domain of NMDA receptors
      pfam10608
      Location:106190
      MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK
    14. XM_006521770.5XP_006521833.1  disks large homolog 1 isoform X14

      Conserved Domains (6) summary
      cd12031
      Location:486552
      SH3_DLG1; Src Homology 3 domain of Disks Large homolog 1
      smart00228
      Location:367451
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00992
      Location:128212
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00625
      Location:652830
      Guanylate_kin; Guanylate kinase
      pfam10600
      Location:308369
      PDZ_assoc; PDZ-associated domain of NMDA receptors
      pfam10608
      Location:10127
      MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK
    15. XM_030248962.2XP_030104822.1  disks large homolog 1 isoform X18

      Conserved Domains (6) summary
      cd12031
      Location:453519
      SH3_DLG1; Src Homology 3 domain of Disks Large homolog 1
      smart00228
      Location:334418
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00992
      Location:95179
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00625
      Location:619797
      Guanylate_kin; Guanylate kinase
      pfam10600
      Location:275336
      PDZ_assoc; PDZ-associated domain of NMDA receptors
      pfam10608
      Location:1094
      MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK
    16. XM_017316869.2XP_017172358.1  disks large homolog 1 isoform X22

      Conserved Domains (6) summary
      cd12031
      Location:453519
      SH3_DLG1; Src Homology 3 domain of Disks Large homolog 1
      smart00228
      Location:334418
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00992
      Location:95179
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00625
      Location:597775
      Guanylate_kin; Guanylate kinase
      pfam10600
      Location:275336
      PDZ_assoc; PDZ-associated domain of NMDA receptors
      pfam10608
      Location:1094
      MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK
    17. XM_006521769.4XP_006521832.1  disks large homolog 1 isoform X13

      Conserved Domains (7) summary
      cd12031
      Location:499565
      SH3_DLG1; Src Homology 3 domain of Disks Large homolog 1
      smart00228
      Location:380464
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      COG3087
      Location:30130
      FtsN; Cell division protein FtsN [Cell cycle control, cell division, chromosome partitioning]
      cd00992
      Location:141225
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00625
      Location:665843
      Guanylate_kin; Guanylate kinase
      pfam10600
      Location:321382
      PDZ_assoc; PDZ-associated domain of NMDA receptors
      pfam10608
      Location:107140
      MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK
    18. XM_030248961.2XP_030104821.1  disks large homolog 1 isoform X16

      Conserved Domains (7) summary
      cd12031
      Location:499565
      SH3_DLG1; Src Homology 3 domain of Disks Large homolog 1
      smart00228
      Location:380464
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      COG3087
      Location:30130
      FtsN; Cell division protein FtsN [Cell cycle control, cell division, chromosome partitioning]
      cd00992
      Location:141225
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00625
      Location:631809
      Guanylate_kin; Guanylate kinase
      pfam10600
      Location:321382
      PDZ_assoc; PDZ-associated domain of NMDA receptors
      pfam10608
      Location:107140
      MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK
    19. XM_017316867.3XP_017172356.1  disks large homolog 1 isoform X17

      Conserved Domains (7) summary
      cd12031
      Location:484550
      SH3_DLG1; Src Homology 3 domain of Disks Large homolog 1
      smart00228
      Location:365449
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      COG3087
      Location:30130
      FtsN; Cell division protein FtsN [Cell cycle control, cell division, chromosome partitioning]
      cd00992
      Location:141225
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00625
      Location:628806
      Guanylate_kin; Guanylate kinase
      pfam10600
      Location:323367
      PDZ_assoc; PDZ-associated domain of NMDA receptors
      pfam10608
      Location:107140
      MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK
    20. XM_006521771.4XP_006521834.1  disks large homolog 1 isoform X15

      Conserved Domains (6) summary
      cd12031
      Location:466532
      SH3_DLG1; Src Homology 3 domain of Disks Large homolog 1
      smart00228
      Location:347431
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00992
      Location:108192
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00625
      Location:632810
      Guanylate_kin; Guanylate kinase
      pfam10600
      Location:288349
      PDZ_assoc; PDZ-associated domain of NMDA receptors
      pfam10608
      Location:78107
      MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK
    21. XM_006521772.4XP_006521835.1  disks large homolog 1 isoform X19

      Conserved Domains (6) summary
      cd12031
      Location:466532
      SH3_DLG1; Src Homology 3 domain of Disks Large homolog 1
      smart00228
      Location:347431
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00992
      Location:108192
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00625
      Location:610788
      Guanylate_kin; Guanylate kinase
      pfam10600
      Location:288349
      PDZ_assoc; PDZ-associated domain of NMDA receptors
      pfam10608
      Location:78107
      MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK
    22. XM_036159768.1XP_036015661.1  disks large homolog 1 isoform X20

      Conserved Domains (6) summary
      cd12031
      Location:466532
      SH3_DLG1; Src Homology 3 domain of Disks Large homolog 1
      smart00228
      Location:347431
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00992
      Location:108192
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00625
      Location:605783
      Guanylate_kin; Guanylate kinase
      pfam10600
      Location:288349
      PDZ_assoc; PDZ-associated domain of NMDA receptors
      pfam10608
      Location:29107
      MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK
    23. XM_006521773.4XP_006521836.1  disks large homolog 1 isoform X21

      Conserved Domains (6) summary
      cd12031
      Location:466532
      SH3_DLG1; Src Homology 3 domain of Disks Large homolog 1
      smart00228
      Location:347431
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00992
      Location:108192
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00625
      Location:598776
      Guanylate_kin; Guanylate kinase
      pfam10600
      Location:288349
      PDZ_assoc; PDZ-associated domain of NMDA receptors
      pfam10608
      Location:78107
      MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK
    24. XM_036159769.1XP_036015662.1  disks large homolog 1 isoform X23

      Conserved Domains (6) summary
      cd12031
      Location:451517
      SH3_DLG1; Src Homology 3 domain of Disks Large homolog 1
      smart00228
      Location:332416
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00992
      Location:108192
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00625
      Location:595773
      Guanylate_kin; Guanylate kinase
      pfam10600
      Location:290334
      PDZ_assoc; PDZ-associated domain of NMDA receptors
      pfam10608
      Location:29107
      MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK
    25. XM_036159770.1XP_036015663.1  disks large homolog 1 isoform X24

      Conserved Domains (6) summary
      cd12031
      Location:451517
      SH3_DLG1; Src Homology 3 domain of Disks Large homolog 1
      smart00228
      Location:332416
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00992
      Location:108192
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00625
      Location:590768
      Guanylate_kin; Guanylate kinase
      pfam10600
      Location:290334
      PDZ_assoc; PDZ-associated domain of NMDA receptors
      pfam10608
      Location:29107
      MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK

    RNA

    1. XR_004939156.1 RNA Sequence

    2. XR_004939157.1 RNA Sequence

    3. XR_004939159.1 RNA Sequence

    4. XR_004939158.1 RNA Sequence

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