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    Dld dihydrolipoamide dehydrogenase [ Mus musculus (house mouse) ]

    Gene ID: 13382, updated on 12-Aug-2018

    Summary

    Official Symbol
    Dldprovided by MGI
    Official Full Name
    dihydrolipoamide dehydrogenaseprovided by MGI
    Primary source
    MGI:MGI:107450
    See related
    Ensembl:ENSMUSG00000020664
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    This gene encodes a member of the class-I pyridine nucleotide-disulfide oxidoreductase family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. In homodimeric form, the encoded protein functions as a dehydrogenase and is found in several multi-enzyme complexes that regulate energy metabolism. However, as a monomer, this protein can function as a protease. [provided by RefSeq, Jan 2014]
    Expression
    Ubiquitous expression in placenta adult (RPKM 46.8), heart adult (RPKM 46.1) and 24 other tissues See more
    Orthologs

    Genomic context

    See Dld in Genome Data Viewer
    Location:
    12 A2; 12 13.43 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 12 NC_000078.6 (31331562..31351471, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 12 NC_000078.5 (32016427..32036302, complement)

    Chromosome 12 - NC_000078.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 32899 Neighboring gene laminin B1 Neighboring gene tripartite motif-containing 13 pseudogene Neighboring gene solute carrier family 26, member 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    NAD binding ISO
    Inferred from Sequence Orthology
    more info
     
    dihydrolipoyl dehydrogenase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    dihydrolipoyl dehydrogenase activity ISO
    Inferred from Sequence Orthology
    more info
     
    electron transfer activity IEA
    Inferred from Electronic Annotation
    more info
     
    flavin adenine dinucleotide binding ISO
    Inferred from Sequence Orthology
    more info
     
    lipoamide binding ISO
    Inferred from Sequence Orthology
    more info
     
    oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
     
    oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    contributes_to pyruvate dehydrogenase (NAD+) activity IC
    Inferred by Curator
    more info
    PubMed 
    contributes_to pyruvate dehydrogenase (NAD+) activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    2-oxoglutarate metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    acetyl-CoA biosynthetic process from pyruvate ISO
    Inferred from Sequence Orthology
    more info
     
    cell redox homeostasis IEA
    Inferred from Electronic Annotation
    more info
     
    dihydrolipoamide metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    gastrulation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    histone succinylation ISO
    Inferred from Sequence Orthology
    more info
     
    lipoate metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    mitochondrial acetyl-CoA biosynthetic process from pyruvate IC
    Inferred by Curator
    more info
    PubMed 
    mitochondrial acetyl-CoA biosynthetic process from pyruvate ISO
    Inferred from Sequence Orthology
    more info
     
    mitochondrial electron transport, NADH to ubiquinone IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    oxidation-reduction process IEA
    Inferred from Electronic Annotation
    more info
     
    proteolysis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of membrane potential IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    sperm capacitation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    acrosomal matrix IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell projection IEA
    Inferred from Electronic Annotation
    more info
     
    cilium IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
     
    mitochondrion HDA PubMed 
    mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    motile cilium IEA
    Inferred from Electronic Annotation
    more info
     
    myelin sheath IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    oxoglutarate dehydrogenase complex ISO
    Inferred from Sequence Orthology
    more info
     
    pyruvate dehydrogenase complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    dihydrolipoyl dehydrogenase, mitochondrial
    Names
    branched chain alpha-keto acid dehydrogenase complex subunit E3
    NP_031887.2

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_007861.5NP_031887.2  dihydrolipoyl dehydrogenase, mitochondrial precursor

      See identical proteins and their annotated locations for NP_031887.2

      Status: REVIEWED

      Source sequence(s)
      AI849462, AK117104, BY282701
      Consensus CDS
      CCDS36428.1
      UniProtKB/Swiss-Prot
      O08749
      Related
      ENSMUSP00000106481.3, ENSMUST00000110857.4
      Conserved Domains (1) summary
      cl26177
      Location:43508
      Pyr_redox_2; Pyridine nucleotide-disulphide oxidoreductase

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000078.6 Reference GRCm38.p4 C57BL/6J

      Range
      31331562..31351471 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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