Format

Send to:

Choose Destination
    • Showing Current items.

    Dffa DNA fragmentation factor, alpha subunit [ Mus musculus (house mouse) ]

    Gene ID: 13347, updated on 31-Jan-2019

    Summary

    Official Symbol
    Dffaprovided by MGI
    Official Full Name
    DNA fragmentation factor, alpha subunitprovided by MGI
    Primary source
    MGI:MGI:1196227
    See related
    Ensembl:ENSMUSG00000028974
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ICAD; DFF35; Dff45; ICAD-L; ICAD-S; A330085O09Rik
    Expression
    Ubiquitous expression in placenta adult (RPKM 12.5), cerebellum adult (RPKM 12.3) and 28 other tissues See more
    Orthologs

    Genomic context

    See Dffa in Genome Data Viewer
    Location:
    4; 4 E2
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 4 NC_000070.6 (149104142..149120653)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 4 NC_000070.5 (148478262..148494759)

    Chromosome 4 - NC_000070.6Genomic Context describing neighboring genes Neighboring gene peroxisomal biogenesis factor 14 Neighboring gene bolA-like 3 pseudogene Neighboring gene predicted gene, 46722 Neighboring gene cortistatin Neighboring gene centromere protein S

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    deoxyribonuclease inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein binding involved in protein folding ISO
    Inferred from Sequence Orthology
    more info
     
    protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    apoptotic DNA fragmentation IEA
    Inferred from Electronic Annotation
    more info
     
    apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    chaperone-mediated protein folding ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of apoptotic DNA fragmentation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of apoptotic DNA fragmentation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    negative regulation of deoxyribonuclease activity ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of execution phase of apoptosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    negative regulation of execution phase of apoptosis ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    thymocyte apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    lipid droplet IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nuclear chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nuclear chromatin ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    DNA fragmentation factor subunit alpha
    Names
    DNA fragmentation factor 45 kDa subunit
    inhibitor of CAD

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001025296.2NP_001020467.1  DNA fragmentation factor subunit alpha isoform a

      See identical proteins and their annotated locations for NP_001020467.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a).
      Source sequence(s)
      AA512775, AI956986, AK051011, BY170336, BY208552
      Consensus CDS
      CCDS18951.1
      UniProtKB/Swiss-Prot
      O54786
      Related
      ENSMUSP00000030816.3, ENSMUST00000030816.3
      Conserved Domains (2) summary
      cd06536
      Location:1796
      CIDE_N_ICAD; CIDE_N domain of ICAD. The CIDE_N (cell death-inducing DFF45-like effector, N-terminal) domain is found at the N-terminus of the CAD nuclease (caspase-activated DNase/DNA fragmentation factor, DFF40) and its inhibitor, ICAD (DFF45). These proteins are ...
      pfam09033
      Location:100263
      DFF-C; DNA Fragmentation factor 45kDa, C terminal domain
    2. NM_010044.3NP_034174.2  DNA fragmentation factor subunit alpha isoform b

      See identical proteins and their annotated locations for NP_034174.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains an alternate 3' terminal exon, resulting in a different 3' UTR and 3' coding region, compared to variant 1. It encodes isoform b, which has a shorter and distinct C-terminus compared to isoform a.
      Source sequence(s)
      AK079634, BY170336, BY208552
      Consensus CDS
      CCDS18952.1
      UniProtKB/TrEMBL
      Q8C535
      Related
      ENSMUSP00000099505.3, ENSMUST00000103216.9
      Conserved Domains (2) summary
      cd06536
      Location:1796
      CIDE_N_ICAD; CIDE_N domain of ICAD. The CIDE_N (cell death-inducing DFF45-like effector, N-terminal) domain is found at the N-terminus of the CAD nuclease (caspase-activated DNase/DNA fragmentation factor, DFF40) and its inhibitor, ICAD (DFF45). These proteins are ...
      pfam09033
      Location:100261
      DFF-C; DNA Fragmentation factor 45kDa, C terminal domain

    RNA

    1. NR_104263.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks two internal exons and uses alternate splice sites in two other internal exons, compared to variant 1. This variant is represented as non-coding because the longest open reading frame is in a different frame compared to variant 1, and there is no support for the predicted protein encoded by this ORF.
      Source sequence(s)
      AI116789, AI956986, AK039227, AK051011, BU695917, BY170336

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000070.6 Reference GRCm38.p4 C57BL/6J

      Range
      149104142..149120653
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCm38.p4 NOD/MrkTac

    Genomic

    1. NT_166299.2 Reference GRCm38.p4 NOD/MrkTac

      Range
      2524557..2541230
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Support Center