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    PDCL2 phosducin like 2 [ Homo sapiens (human) ]

    Gene ID: 132954, updated on 11-Apr-2024

    Summary

    Official Symbol
    PDCL2provided by HGNC
    Official Full Name
    phosducin like 2provided by HGNC
    Primary source
    HGNC:HGNC:29524
    See related
    Ensembl:ENSG00000163440 MIM:611676; AllianceGenome:HGNC:29524
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    GCPHLP
    Summary
    This gene encodes a member of the phosducin-like protein family and is a putative modulator of heterotrimeric G proteins. The protein shares extensive amino acid sequence homology with phosducin. Members of the phosducin-like protein family have been shown to bind to the beta-gamma subunits of G proteins. [provided by RefSeq, Jul 2008]
    Expression
    Restricted expression toward testis (RPKM 13.2) See more
    Orthologs
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    Genomic context

    See PDCL2 in Genome Data Viewer
    Location:
    4q12
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (55556519..55592245, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (59044647..59080385, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (56422686..56458412, complement)

    Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene clock circadian regulator Neighboring gene uncharacterized LOC124900704 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15440 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15441 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15442 Neighboring gene RN7SK pseudogene 30 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15443 Neighboring gene neuromedin U Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr4:56501035-56501786 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr4:56501787-56502538 Neighboring gene uncharacterized LOC105377660

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in acrosome assembly IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein folding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in sperm axoneme assembly IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
     

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_152401.3NP_689614.2  phosducin-like protein 2

      See identical proteins and their annotated locations for NP_689614.2

      Status: REVIEWED

      Source sequence(s)
      AC024243, AW629089, BC034431, BG198696
      Consensus CDS
      CCDS47059.1
      UniProtKB/Swiss-Prot
      A8MWA2, B9ZVQ9, Q8N4E4
      Related
      ENSP00000295645.4, ENST00000295645.9
      Conserved Domains (1) summary
      cd02988
      Location:8200
      Phd_like_VIAF; Phosducin (Phd)-like family, Viral inhibitor of apoptosis (IAP)-associated factor (VIAF) subfamily; VIAF is a Phd-like protein that functions in caspase activation during apoptosis. It was identified as an IAP binding protein through a screen of a human ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

      Range
      55556519..55592245 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005265728.4XP_005265785.1  phosducin-like protein 2 isoform X3

      Conserved Domains (1) summary
      cl00388
      Location:8120
      Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
    2. XM_011534374.3XP_011532676.1  phosducin-like protein 2 isoform X1

      Conserved Domains (1) summary
      cd02988
      Location:6168
      Phd_like_VIAF; Phosducin (Phd)-like family, Viral inhibitor of apoptosis (IAP)-associated factor (VIAF) subfamily; VIAF is a Phd-like protein that functions in caspase activation during apoptosis. It was identified as an IAP binding protein through a screen of a human ...
    3. XM_047449616.1XP_047305572.1  phosducin-like protein 2 isoform X2

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060928.1 Alternate T2T-CHM13v2.0

      Range
      59044647..59080385 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054348945.1XP_054204920.1  phosducin-like protein 2 isoform X3

    2. XM_054348943.1XP_054204918.1  phosducin-like protein 2 isoform X1

    3. XM_054348944.1XP_054204919.1  phosducin-like protein 2 isoform X2