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    COX5B cytochrome c oxidase subunit 5B [ Homo sapiens (human) ]

    Gene ID: 1329, updated on 5-Mar-2024

    Summary

    Official Symbol
    COX5Bprovided by HGNC
    Official Full Name
    cytochrome c oxidase subunit 5Bprovided by HGNC
    Primary source
    HGNC:HGNC:2269
    See related
    Ensembl:ENSG00000135940 MIM:123866; AllianceGenome:HGNC:2269
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    COXVB
    Summary
    Cytochrome C oxidase (COX) is the terminal enzyme of the mitochondrial respiratory chain. It is a multi-subunit enzyme complex that couples the transfer of electrons from cytochrome c to molecular oxygen and contributes to a proton electrochemical gradient across the inner mitochondrial membrane. The complex consists of 13 mitochondrial- and nuclear-encoded subunits. The mitochondrially-encoded subunits perform the electron transfer and proton pumping activities. The functions of the nuclear-encoded subunits are unknown but they may play a role in the regulation and assembly of the complex. This gene encodes the nuclear-encoded subunit Vb of the human mitochondrial respiratory chain enzyme. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in colon (RPKM 200.2), kidney (RPKM 188.7) and 24 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See COX5B in Genome Data Viewer
    Location:
    2q11.2
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (97646062..97648383)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (98104283..98106604)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (98262525..98264846)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105373499 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:98233139-98233656 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:98235127-98236008 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:98238522-98239022 Neighboring gene MPRA-validated peak3795 silencer Neighboring gene UBTF like 6 (pseudogene) Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:98261483-98262417 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16239 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:98278969-98279610 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11792 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11793 Neighboring gene actin related protein 1B Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16241 Neighboring gene U4 spliceosomal RNA Neighboring gene chromosome 2 open reading frame 92 Neighboring gene RNA, U4 small nuclear 8, pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat Tat-induced mitochondrial membrane permeabilization is associated with inhibition of cytochrome c oxidase (COX) activity by Tat in disrupted mitochondria from human samples PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables cytochrome-c oxidase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane TAS
    Traceable Author Statement
    more info
     
    located_in mitochondrial membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of mitochondrial respiratory chain complex IV IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
     

    General protein information

    Preferred Names
    cytochrome c oxidase subunit 5B, mitochondrial
    Names
    cytochrome c oxidase polypeptide VB, mitochondrial
    cytochrome c oxidase subunit Vb
    epididymis secretory sperm binding protein
    NP_001853.2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001862.3NP_001853.2  cytochrome c oxidase subunit 5B, mitochondrial precursor

      See identical proteins and their annotated locations for NP_001853.2

      Status: REVIEWED

      Source sequence(s)
      AC017099, BC006229
      Consensus CDS
      CCDS2032.1
      UniProtKB/Swiss-Prot
      P10606, Q53YB7, Q96J18, Q99610
      UniProtKB/TrEMBL
      A0A384NL93, Q6FHJ9, Q6FHM4
      Related
      ENSP00000258424.2, ENST00000258424.3
      Conserved Domains (1) summary
      cd00924
      Location:32128
      Cyt_c_Oxidase_Vb; Cytochrome c oxidase subunit Vb. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      97646062..97648383
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p14 PATCHES

    Genomic

    1. NW_025791765.1 Reference GRCh38.p14 PATCHES

      Range
      572093..574414
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      98104283..98106604
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)