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    Ddx6 DEAD (Asp-Glu-Ala-Asp) box polypeptide 6 [ Mus musculus (house mouse) ]

    Gene ID: 13209, updated on 20-Jul-2021

    Summary

    Official Symbol
    Ddx6provided by MGI
    Official Full Name
    DEAD (Asp-Glu-Ala-Asp) box polypeptide 6provided by MGI
    Primary source
    MGI:MGI:104976
    See related
    Ensembl:ENSMUSG00000032097
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    HL; p5; rc; p54; rck; HLR2; mRCK/P; mRCK/P54; 1110001P04Rik; C430015D01Rik; E230023J21Rik
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 19.5), CNS E14 (RPKM 15.0) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Ddx6 in Genome Data Viewer
    Location:
    9 A5.2; 9 24.84 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (44514113..44552028)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (44602983..44640731)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 9 NC_000075.5 (44412975..44448814)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene B cell CLL/lymphoma 9-like Neighboring gene chemokine (C-X-C motif) receptor 5 Neighboring gene predicted gene, 50603 Neighboring gene predicted gene, 30671 Neighboring gene cDNA sequence BC049987 Neighboring gene NSA2 ribosome biogenesis homolog pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables RNA helicase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables helicase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in P-body assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within P-body assembly ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    involved_in P-body assembly ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of neuron differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of translation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of miRNA mediated inhibition of translation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within stem cell population maintenance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in stress granule assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in viral RNA genome packaging ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in P-body IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in P-body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in P-body ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    part_of RISC complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in adherens junction ISO
    Inferred from Sequence Orthology
    more info
     
    located_in chromatoid body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in concave side of sperm head ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasmic ribonucleoprotein granule ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytoplasmic stress granule IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytoplasmic stress granule ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in heterochromatin ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in outer dense fiber ISO
    Inferred from Sequence Orthology
    more info
     
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in sperm annulus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    probable ATP-dependent RNA helicase DDX6
    Names
    ATP-dependent RNA helicase p54
    D-E-A-D (aspartate-glutamate-alanine-aspartate) box polypeptide 6
    DEAD (aspartate-glutamate-alanine-aspartate) box polypeptide 6
    DEAD box protein 6
    DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 6
    oncogene RCK homolog
    NP_001104296.1
    NP_001344631.1
    NP_001344632.1
    NP_031867.1
    NP_851841.2
    XP_011240693.1
    XP_030099902.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001110826.1NP_001104296.1  probable ATP-dependent RNA helicase DDX6

      See identical proteins and their annotated locations for NP_001104296.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) differs in the 5' UTR compared to variant 5. All five variants encode the same protein.
      Source sequence(s)
      AC151971, AK148483, CN528354
      Consensus CDS
      CCDS23116.1
      UniProtKB/Swiss-Prot
      P54823
      Related
      ENSMUSP00000128421.2, ENSMUST00000170489.2
      Conserved Domains (2) summary
      cd18787
      Location:309438
      SF2_C_DEAD; C-terminal helicase domain of the DEAD box helicases
      cd17940
      Location:98299
      DEADc_DDX6; DEAD-box helicase domain of DEAD box protein 6
    2. NM_001357702.1NP_001344631.1  probable ATP-dependent RNA helicase DDX6

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 5. All five variants encode the same protein.
      Source sequence(s)
      AC151971
      Consensus CDS
      CCDS23116.1
      Conserved Domains (2) summary
      cd18787
      Location:309438
      SF2_C_DEAD; C-terminal helicase domain of the DEAD box helicases
      cd17940
      Location:98299
      DEADc_DDX6; DEAD-box helicase domain of DEAD box protein 6
    3. NM_001357703.1NP_001344632.1  probable ATP-dependent RNA helicase DDX6

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) represents the longest transcript. All five variants encode the same protein.
      Source sequence(s)
      AC151971
      Consensus CDS
      CCDS23116.1
      Conserved Domains (2) summary
      cd18787
      Location:309438
      SF2_C_DEAD; C-terminal helicase domain of the DEAD box helicases
      cd17940
      Location:98299
      DEADc_DDX6; DEAD-box helicase domain of DEAD box protein 6
    4. NM_007841.4NP_031867.1  probable ATP-dependent RNA helicase DDX6

      See identical proteins and their annotated locations for NP_031867.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 5. All five variants encode the same protein.
      Source sequence(s)
      AC151971, AK148483, CD353843
      Consensus CDS
      CCDS23116.1
      UniProtKB/Swiss-Prot
      P54823
      Conserved Domains (2) summary
      cd18787
      Location:309438
      SF2_C_DEAD; C-terminal helicase domain of the DEAD box helicases
      cd17940
      Location:98299
      DEADc_DDX6; DEAD-box helicase domain of DEAD box protein 6
    5. NM_181324.3NP_851841.2  probable ATP-dependent RNA helicase DDX6

      See identical proteins and their annotated locations for NP_851841.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 5. All five variants encode the same protein.
      Source sequence(s)
      AC151971, AK148483
      Consensus CDS
      CCDS23116.1
      UniProtKB/Swiss-Prot
      P54823
      Related
      ENSMUSP00000149620.2, ENSMUST00000217034.2
      Conserved Domains (2) summary
      cd18787
      Location:309438
      SF2_C_DEAD; C-terminal helicase domain of the DEAD box helicases
      cd17940
      Location:98299
      DEADc_DDX6; DEAD-box helicase domain of DEAD box protein 6

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      44514113..44552028
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011242391.4XP_011240693.1  probable ATP-dependent RNA helicase DDX6 isoform X1

      See identical proteins and their annotated locations for XP_011240693.1

      UniProtKB/Swiss-Prot
      P54823
      Conserved Domains (2) summary
      cd18787
      Location:309438
      SF2_C_DEAD; C-terminal helicase domain of the DEAD box helicases
      cd17940
      Location:98299
      DEADc_DDX6; DEAD-box helicase domain of DEAD box protein 6
    2. XM_030244042.2XP_030099902.1  probable ATP-dependent RNA helicase DDX6 isoform X1

      Conserved Domains (2) summary
      cd18787
      Location:309438
      SF2_C_DEAD; C-terminal helicase domain of the DEAD box helicases
      cd17940
      Location:98299
      DEADc_DDX6; DEAD-box helicase domain of DEAD box protein 6
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