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    Ddx6 DEAD (Asp-Glu-Ala-Asp) box polypeptide 6 [ Mus musculus (house mouse) ]

    Gene ID: 13209, updated on 31-Jan-2019

    Summary

    Official Symbol
    Ddx6provided by MGI
    Official Full Name
    DEAD (Asp-Glu-Ala-Asp) box polypeptide 6provided by MGI
    Primary source
    MGI:MGI:104976
    See related
    Ensembl:ENSMUSG00000032097
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    p54; rck; HLR2; mRCK/P54; 1110001P04Rik; C430015D01Rik; E230023J21Rik
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 19.5), CNS E14 (RPKM 15.0) and 28 other tissues See more
    Orthologs

    Genomic context

    See Ddx6 in Genome Data Viewer
    Location:
    9 A5.2; 9 24.84 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 9 NC_000075.6 (44603817..44640731)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 9 NC_000075.5 (44412975..44448814)

    Chromosome 9 - NC_000075.6Genomic Context describing neighboring genes Neighboring gene B cell CLL/lymphoma 9-like Neighboring gene chemokine (C-X-C motif) receptor 5 Neighboring gene uncharacterized LOC108167647 Neighboring gene predicted gene, 30671 Neighboring gene NSA2 ribosome biogenesis homolog pseudogene Neighboring gene trehalase (brush-border membrane glycoprotein)

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    RNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    helicase activity IEA
    Inferred from Electronic Annotation
    more info
     
    hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    cytoplasmic mRNA processing body assembly ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    negative regulation of neuron differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    stem cell population maintenance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    viral RNA genome packaging ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    P-body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    P-body ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    RISC complex ISO
    Inferred from Sequence Orthology
    more info
     
    cell-cell adherens junction ISO
    Inferred from Sequence Orthology
    more info
     
    chromatoid body ISO
    Inferred from Sequence Orthology
    more info
     
    concave side of sperm head ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasmic ribonucleoprotein granule ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasmic stress granule ISO
    Inferred from Sequence Orthology
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    heterochromatin ISO
    Inferred from Sequence Orthology
    more info
     
    mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    nucleolus ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    outer dense fiber ISO
    Inferred from Sequence Orthology
    more info
     
    perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    sperm annulus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    probable ATP-dependent RNA helicase DDX6
    Names
    ATP-dependent RNA helicase p54
    D-E-A-D (aspartate-glutamate-alanine-aspartate) box polypeptide 6
    DEAD (aspartate-glutamate-alanine-aspartate) box polypeptide 6
    DEAD box protein 6
    DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 6
    oncogene RCK homolog
    NP_001104296.1
    NP_031867.1
    NP_851841.2
    XP_011240693.1
    XP_011240694.1
    XP_017168613.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001110826.1NP_001104296.1  probable ATP-dependent RNA helicase DDX6

      See identical proteins and their annotated locations for NP_001104296.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) differs in the 5' UTR compared to variant 5. All five variants encode the same protein.
      Source sequence(s)
      AC151971, AK148483, CN528354
      Consensus CDS
      CCDS23116.1
      UniProtKB/Swiss-Prot
      P54823
      Related
      ENSMUSP00000128421.1, ENSMUST00000170489.1
      Conserved Domains (1) summary
      COG0513
      Location:80458
      SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]
    2. NM_001357702.1NP_001344631.1  probable ATP-dependent RNA helicase DDX6

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 5. All five variants encode the same protein.
      Source sequence(s)
      AC151971
      Conserved Domains (1) summary
      COG0513
      Location:80458
      SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]
    3. NM_001357703.1NP_001344632.1  probable ATP-dependent RNA helicase DDX6

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) represents the longest transcript. All five variants encode the same protein.
      Source sequence(s)
      AC151971
      Conserved Domains (1) summary
      COG0513
      Location:80458
      SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]
    4. NM_007841.4NP_031867.1  probable ATP-dependent RNA helicase DDX6

      See identical proteins and their annotated locations for NP_031867.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 5. All five variants encode the same protein.
      Source sequence(s)
      AC151971, AK148483, CD353843
      Consensus CDS
      CCDS23116.1
      UniProtKB/Swiss-Prot
      P54823
      Conserved Domains (1) summary
      COG0513
      Location:80458
      SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]
    5. NM_181324.3NP_851841.2  probable ATP-dependent RNA helicase DDX6

      See identical proteins and their annotated locations for NP_851841.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 5. All five variants encode the same protein.
      Source sequence(s)
      AC151971, AK148483
      Consensus CDS
      CCDS23116.1
      UniProtKB/Swiss-Prot
      P54823
      Related
      ENSMUSP00000149620.1, ENSMUST00000217034.1
      Conserved Domains (1) summary
      COG0513
      Location:80458
      SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000075.6 Reference GRCm38.p4 C57BL/6J

      Range
      44603817..44640731
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011242391.2XP_011240693.1  probable ATP-dependent RNA helicase DDX6 isoform X1

      See identical proteins and their annotated locations for XP_011240693.1

      UniProtKB/Swiss-Prot
      P54823
      Conserved Domains (1) summary
      COG0513
      Location:80458
      SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]
    2. XM_011242392.2XP_011240694.1  probable ATP-dependent RNA helicase DDX6 isoform X1

      UniProtKB/Swiss-Prot
      P54823
      Conserved Domains (1) summary
      COG0513
      Location:80458
      SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]
    3. XM_017313124.1XP_017168613.1  probable ATP-dependent RNA helicase DDX6 isoform X1

      UniProtKB/Swiss-Prot
      P54823
      Conserved Domains (1) summary
      COG0513
      Location:80458
      SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]
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