Format

Send to:

Choose Destination
    • Showing Current items.

    Ddx5 DEAD (Asp-Glu-Ala-Asp) box polypeptide 5 [ Mus musculus (house mouse) ]

    Gene ID: 13207, updated on 3-Feb-2019

    Summary

    Official Symbol
    Ddx5provided by MGI
    Official Full Name
    DEAD (Asp-Glu-Ala-Asp) box polypeptide 5provided by MGI
    Primary source
    MGI:MGI:105037
    See related
    Ensembl:ENSMUSG00000020719
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    p68; Hlr1; G17P1; HUMP68; 2600009A06Rik
    Expression
    Ubiquitous expression in adrenal adult (RPKM 253.6), CNS E14 (RPKM 165.9) and 28 other tissues See more
    Orthologs

    Genomic context

    See Ddx5 in Genome Data Viewer
    Location:
    11 E1; 11 70.01 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 11 NC_000077.6 (106780355..106789180, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (106641670..106649808, complement)

    Chromosome 11 - NC_000077.6Genomic Context describing neighboring genes Neighboring gene platelet/endothelial cell adhesion molecule 1 Neighboring gene mast cell immunoglobulin like receptor 1 Neighboring gene polymerase (DNA directed), gamma 2, accessory subunit Neighboring gene microRNA 3064 Neighboring gene centrosomal protein 95 Neighboring gene SMAD specific E3 ubiquitin protein ligase 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC118083

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    ATP-dependent RNA helicase activity ISO
    Inferred from Sequence Orthology
    more info
     
    MH2 domain binding ISO
    Inferred from Sequence Orthology
    more info
     
    R-SMAD binding ISO
    Inferred from Sequence Orthology
    more info
     
    RNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    RNA helicase activity ISO
    Inferred from Sequence Orthology
    more info
     
    SMAD binding ISO
    Inferred from Sequence Orthology
    more info
     
    androgen receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    calcium-dependent protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    calmodulin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    helicase activity IEA
    Inferred from Electronic Annotation
    more info
     
    hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    mRNA 3'-UTR binding ISO
    Inferred from Sequence Orthology
    more info
     
    nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    pre-mRNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    primary miRNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    promoter-specific chromatin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    ribonucleoprotein complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    transcription coregulator activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    BMP signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    RNA splicing IEA
    Inferred from Electronic Annotation
    more info
     
    alternative mRNA splicing, via spliceosome IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    alternative mRNA splicing, via spliceosome ISO
    Inferred from Sequence Orthology
    more info
     
    androgen receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    circadian rhythm IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    epithelial to mesenchymal transition ISO
    Inferred from Sequence Orthology
    more info
     
    intracellular estrogen receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    intrinsic apoptotic signaling pathway by p53 class mediator ISO
    Inferred from Sequence Orthology
    more info
     
    mRNA processing IEA
    Inferred from Electronic Annotation
    more info
     
    mRNA transcription ISO
    Inferred from Sequence Orthology
    more info
     
    myoblast differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear-transcribed mRNA catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of DNA damage response, signal transduction by p53 class mediator ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of production of miRNAs involved in gene silencing by miRNA ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription, DNA-templated IDA
    Inferred from Direct Assay
    more info
    PubMed 
    pri-miRNA transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein import into nucleus IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    regulation of alternative mRNA splicing, via spliceosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of alternative mRNA splicing, via spliceosome ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of androgen receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of osteoblast differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of skeletal muscle cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of viral genome replication ISO
    Inferred from Sequence Orthology
    more info
     
    rhythmic process IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    catalytic step 2 spliceosome ISO
    Inferred from Sequence Orthology
    more info
     
    nucleolus ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IC
    Inferred by Curator
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    ribonucleoprotein complex ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    ribonucleoprotein granule IDA
    Inferred from Direct Assay
    more info
    PubMed 
    spliceosomal complex IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    probable ATP-dependent RNA helicase DDX5
    Names
    DEAD (aspartate-glutamate-alanine-aspartate) box polypeptide 5
    DEAD box RNA helicase DEAD1
    DEAD box protein 5
    DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 5
    RNA helicase p68
    mDEAD1
    NP_031866.2
    XP_006532198.1
    XP_006532199.1
    XP_006532200.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001355676.1NP_001342605.1  probable ATP-dependent RNA helicase DDX5

      Status: VALIDATED

      Source sequence(s)
      AK166698, BC062916, CJ173936
      Conserved Domains (2) summary
      pfam08061
      Location:551583
      P68HR; P68HR (NUC004) repeat
      cl26939
      Location:6507
      DEXDc; DEAD-like helicases superfamily
    2. NM_001355677.1NP_001342606.1  probable ATP-dependent RNA helicase DDX5

      Status: VALIDATED

      Source sequence(s)
      AL603664, BC062916
      Conserved Domains (2) summary
      pfam08061
      Location:551583
      P68HR; P68HR (NUC004) repeat
      cl26939
      Location:6507
      DEXDc; DEAD-like helicases superfamily
    3. NM_007840.3NP_031866.2  probable ATP-dependent RNA helicase DDX5

      See identical proteins and their annotated locations for NP_031866.2

      Status: VALIDATED

      Source sequence(s)
      AK166045
      Consensus CDS
      CCDS25562.1
      UniProtKB/TrEMBL
      Q8BTS0
      Related
      ENSMUSP00000021062.5, ENSMUST00000021062.11
      Conserved Domains (2) summary
      pfam08061
      Location:551583
      P68HR; P68HR (NUC004) repeat
      cl26939
      Location:6507
      DEXDc; DEAD-like helicases superfamily

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000077.6 Reference GRCm38.p4 C57BL/6J

      Range
      106780355..106789180 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006532137.3XP_006532200.1  probable ATP-dependent RNA helicase DDX5 isoform X1

      UniProtKB/TrEMBL
      Q8BTS0
      Conserved Domains (2) summary
      pfam08061
      Location:551583
      P68HR; P68HR (NUC004) repeat
      cl26939
      Location:6507
      DEXDc; DEAD-like helicases superfamily
    2. XM_006532135.3XP_006532198.1  probable ATP-dependent RNA helicase DDX5 isoform X1

      UniProtKB/TrEMBL
      Q8BTS0
      Conserved Domains (2) summary
      pfam08061
      Location:551583
      P68HR; P68HR (NUC004) repeat
      cl26939
      Location:6507
      DEXDc; DEAD-like helicases superfamily
    3. XM_006532136.3XP_006532199.1  probable ATP-dependent RNA helicase DDX5 isoform X1

      See identical proteins and their annotated locations for XP_006532199.1

      UniProtKB/TrEMBL
      Q8BTS0
      Conserved Domains (2) summary
      pfam08061
      Location:551583
      P68HR; P68HR (NUC004) repeat
      cl26939
      Location:6507
      DEXDc; DEAD-like helicases superfamily
    Support Center