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    Ddx4 DEAD box helicase 4 [ Mus musculus (house mouse) ]

    Gene ID: 13206, updated on 7-Sep-2021

    Summary

    Official Symbol
    Ddx4provided by MGI
    Official Full Name
    DEAD box helicase 4provided by MGI
    Primary source
    MGI:MGI:102670
    See related
    Ensembl:ENSMUSG00000021758
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Mv; Mvh; VASA; AV206478
    Expression
    Restricted expression toward testis adult (RPKM 29.9) See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Ddx4 in Genome Data Viewer
    Location:
    13 D2.2; 13 63.87 cM
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (112734867..112790342, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (112598333..112652633, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 13 NC_000079.5 (113388541..113442518, complement)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene interleukin 31 receptor A Neighboring gene tubulin, alpha 1B pseudogene Neighboring gene solute carrier family 38, member 9 Neighboring gene heterogeneous nuclear ribonucleoprotein R pseudogene Neighboring gene predicted gene, 41067

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables RNA helicase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables helicase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in DNA methylation involved in gamete generation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in flagellated sperm motility ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in gamete generation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within gene silencing by RNA IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within male meiosis I IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in male meiosis I IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in male meiotic nuclear division IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within meiotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of transposition IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in piRNA biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in piRNA metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of protein localization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within spermatogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in spermatogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in P granule IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in chromatoid body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in chromatoid body ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in pi-body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in piP-body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of ribonucleoprotein complex IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    ATP-dependent RNA helicase DDX4
    Names
    D-E-A-D (aspartate-glutamate-alanine-aspartate) box polypeptide 4
    DEAD (Asp-Glu-Ala-Asp) box polypeptide 4
    DEAD (aspartate-glutamate-alanine-aspartate) box polypeptide 4
    DEAD box polypeptide 4
    DEAD box protein 4
    DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 4
    mvh / m'vasa
    probable ATP-dependent RNA helicase DDX4
    vasa homolog
    NP_001139357.1
    NP_034159.1
    XP_006517587.1
    XP_011242920.1
    XP_011242921.1
    XP_011242923.1
    XP_011242924.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001145885.1NP_001139357.1  ATP-dependent RNA helicase DDX4 isoform 1

      See identical proteins and their annotated locations for NP_001139357.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and it encodes the longer protein (isoform 1).
      Source sequence(s)
      AK133366, BE860399, DT906923
      Consensus CDS
      CCDS49366.1
      UniProtKB/TrEMBL
      Q3V086
      Related
      ENSMUSP00000096769.3, ENSMUST00000099166.10
      Conserved Domains (3) summary
      smart00487
      Location:302502
      DEXDc; DEAD-like helicases superfamily
      cd00079
      Location:513642
      HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
      cd00268
      Location:289496
      DEADc; DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif ...
    2. NM_010029.2NP_034159.1  ATP-dependent RNA helicase DDX4 isoform 2

      See identical proteins and their annotated locations for NP_034159.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon, compared to variant 1. The resulting protein (isoform 2) is shorter when it is compared to isoform 1.
      Source sequence(s)
      AK014844, BE860399, DT906923
      Consensus CDS
      CCDS26774.1
      UniProtKB/Swiss-Prot
      Q61496
      Related
      ENSMUSP00000075157.6, ENSMUST00000075748.7
      Conserved Domains (3) summary
      smart00487
      Location:276476
      DEXDc; DEAD-like helicases superfamily
      cd00079
      Location:487616
      HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
      cd00268
      Location:263470
      DEADc; DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      112734867..112790342 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011244618.3XP_011242920.1  ATP-dependent RNA helicase DDX4 isoform X1

      See identical proteins and their annotated locations for XP_011242920.1

      Conserved Domains (2) summary
      cd18787
      Location:524653
      SF2_C_DEAD; C-terminal helicase domain of the DEAD box helicases
      cd18052
      Location:266518
      DEADc_DDX4; DEAD-box helicase domain of DEAD box protein 4
    2. XM_006517524.5XP_006517587.1  ATP-dependent RNA helicase DDX4 isoform X3

      Conserved Domains (2) summary
      cd18787
      Location:519648
      SF2_C_DEAD; C-terminal helicase domain of the DEAD box helicases
      cd18052
      Location:261513
      DEADc_DDX4; DEAD-box helicase domain of DEAD box protein 4
    3. XM_011244622.4XP_011242924.1  ATP-dependent RNA helicase DDX4 isoform X2

      Conserved Domains (2) summary
      cd18787
      Location:519648
      SF2_C_DEAD; C-terminal helicase domain of the DEAD box helicases
      cd18052
      Location:261513
      DEADc_DDX4; DEAD-box helicase domain of DEAD box protein 4
    4. XM_011244621.3XP_011242923.1  ATP-dependent RNA helicase DDX4 isoform X1

      See identical proteins and their annotated locations for XP_011242923.1

      Conserved Domains (2) summary
      cd18787
      Location:524653
      SF2_C_DEAD; C-terminal helicase domain of the DEAD box helicases
      cd18052
      Location:266518
      DEADc_DDX4; DEAD-box helicase domain of DEAD box protein 4
    5. XM_011244619.3XP_011242921.1  ATP-dependent RNA helicase DDX4 isoform X1

      See identical proteins and their annotated locations for XP_011242921.1

      Conserved Domains (2) summary
      cd18787
      Location:524653
      SF2_C_DEAD; C-terminal helicase domain of the DEAD box helicases
      cd18052
      Location:266518
      DEADc_DDX4; DEAD-box helicase domain of DEAD box protein 4
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