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    Ddx3x DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 3, X-linked [ Mus musculus (house mouse) ]

    Gene ID: 13205, updated on 24-Feb-2019

    Summary

    Official Symbol
    Ddx3xprovided by MGI
    Official Full Name
    DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 3, X-linkedprovided by MGI
    Primary source
    MGI:MGI:103064
    See related
    Ensembl:ENSMUSG00000000787
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ddx3; Fin14; D1Pas1-rs2
    Expression
    Broad expression in CNS E11.5 (RPKM 64.5), placenta adult (RPKM 53.4) and 23 other tissues See more
    Orthologs

    Genomic context

    See Ddx3x in Genome Data Viewer
    Location:
    X A1.1; X 8.17 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) X NC_000086.7 (13280496..13293988)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) X NC_000086.6 (12858148..12871109)

    Chromosome X - NC_000086.7Genomic Context describing neighboring genes Neighboring gene LLP homolog, pseudogene 2 Neighboring gene RIKEN cDNA 2010308F09 gene Neighboring gene ATP-binding cassette, sub-family F (GCN20), member 2 pseudogene Neighboring gene chaperonin containing Tcp1, subunit 7 (eta) pseudogene Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    • Hepatitis B, organism-specific biosystem (from KEGG)
      Hepatitis B, organism-specific biosystemHepatitis B virus (HBV) is an enveloped virus and contains a partially double-stranded relaxed circular DNA (RC-DNA) genome. After entry into hepatocytes, HBV RC-DNA is transported to the nucleus and...
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Innate Immune System, organism-specific biosystem (from REACTOME)
      Innate Immune System, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Neutrophil degranulation, organism-specific biosystem (from REACTOME)
      Neutrophil degranulation, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • RIG-I-like receptor signaling pathway, organism-specific biosystem (from KEGG)
      RIG-I-like receptor signaling pathway, organism-specific biosystemSpecific families of pattern recognition receptors are responsible for detecting viral pathogens and generating innate immune responses. Non-self RNA appearing in a cell as a result of intracellular ...
    • RIG-I-like receptor signaling pathway, conserved biosystem (from KEGG)
      RIG-I-like receptor signaling pathway, conserved biosystemSpecific families of pattern recognition receptors are responsible for detecting viral pathogens and generating innate immune responses. Non-self RNA appearing in a cell as a result of intracellular ...
    • TNF-alpha NF-kB Signaling Pathway, organism-specific biosystem (from WikiPathways)
      TNF-alpha NF-kB Signaling Pathway, organism-specific biosystem
      TNF-alpha NF-kB Signaling Pathway
    • Viral carcinogenesis, organism-specific biosystem (from KEGG)
      Viral carcinogenesis, organism-specific biosystemThere is a strong association between viruses and the development of human malignancies. We now know that at least six human viruses, Epstein-Barr virus (EBV), hepatitis B virus (HBV), hepatitis C vi...
    • Viral carcinogenesis, conserved biosystem (from KEGG)
      Viral carcinogenesis, conserved biosystemThere is a strong association between viruses and the development of human malignancies. We now know that at least six human viruses, Epstein-Barr virus (EBV), hepatitis B virus (HBV), hepatitis C vi...
    • mRNA processing, organism-specific biosystem (from WikiPathways)
      mRNA processing, organism-specific biosystemAdapted from Reactome, see: [http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_1675.1 REACT 1675.1] This process describes the conversion of precursor messenger RNA into mature messenge...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    ATP-dependent DNA helicase activity ISO
    Inferred from Sequence Orthology
    more info
     
    ATP-dependent RNA helicase activity ISO
    Inferred from Sequence Orthology
    more info
     
    ATPase activity ISO
    Inferred from Sequence Orthology
    more info
     
    CTPase activity ISO
    Inferred from Sequence Orthology
    more info
     
    DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    GTPase activity ISO
    Inferred from Sequence Orthology
    more info
     
    RNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    RNA stem-loop binding ISO
    Inferred from Sequence Orthology
    more info
     
    RNA strand annealing activity ISO
    Inferred from Sequence Orthology
    more info
     
    eukaryotic initiation factor 4E binding ISO
    Inferred from Sequence Orthology
    more info
     
    helicase activity IEA
    Inferred from Electronic Annotation
    more info
     
    hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    mRNA 5'-UTR binding ISO
    Inferred from Sequence Orthology
    more info
     
    nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
     
    nucleoside-triphosphatase activity ISO
    Inferred from Sequence Orthology
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    poly(A) binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein serine/threonine kinase activator activity ISO
    Inferred from Sequence Orthology
    more info
     
    ribosomal small subunit binding ISO
    Inferred from Sequence Orthology
    more info
     
    transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    translation initiation factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    RNA secondary structure unwinding ISO
    Inferred from Sequence Orthology
    more info
     
    Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to arsenic-containing substance ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to osmotic stress ISO
    Inferred from Sequence Orthology
    more info
     
    chromosome segregation ISO
    Inferred from Sequence Orthology
    more info
     
    extrinsic apoptotic signaling pathway via death domain receptors ISO
    Inferred from Sequence Orthology
    more info
     
    immune system process IEA
    Inferred from Electronic Annotation
    more info
     
    innate immune response ISO
    Inferred from Sequence Orthology
    more info
     
    intracellular signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    intrinsic apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    mature ribosome assembly ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cell growth ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cysteine-type endopeptidase activity involved in apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of intrinsic apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of protein complex assembly ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of translation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of G1/S transition of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of canonical Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cell growth ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cysteine-type endopeptidase activity involved in apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of translation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of translational initiation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of viral genome replication ISO
    Inferred from Sequence Orthology
    more info
     
    protein localization to cytoplasmic stress granule ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of translation IEA
    Inferred from Electronic Annotation
    more info
     
    response to virus ISO
    Inferred from Sequence Orthology
    more info
     
    ribosome biogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    stress granule assembly ISO
    Inferred from Sequence Orthology
    more info
     
    translational initiation ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasmic stress granule ISO
    Inferred from Sequence Orthology
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with cytosolic small ribosomal subunit ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with eukaryotic translation initiation factor 3 complex ISO
    Inferred from Sequence Orthology
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    mitochondrial outer membrane IEA
    Inferred from Electronic Annotation
    more info
     
    mitochondrion IEA
    Inferred from Electronic Annotation
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    ATP-dependent RNA helicase DDX3X
    Names
    D-E-A-D (aspartate-glutamate-alanine-aspartate) box polypeptide 3
    D1Pas1-related sequence 2
    DEAD (aspartate-glutamate-alanine-aspartate) box polypeptide 3
    DEAD box RNA helicase DEAD3
    DEAD box protein 3, X-chromosomal
    DEAD-box protein 3 (DEAD-box RNA helicase DEAD3) (mDEAD3) (Embryonic RNA helicase) (D1PAS1 related sequence 2)
    embryonic RNA helicase
    fibroblast growth factor inducible 14
    mDEAD3
    NP_034158.1
    XP_006527629.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_010028.3NP_034158.1  ATP-dependent RNA helicase DDX3X

      See identical proteins and their annotated locations for NP_034158.1

      Status: VALIDATED

      Source sequence(s)
      AK163250, AL833805, BB854842
      Consensus CDS
      CCDS30027.1
      UniProtKB/Swiss-Prot
      Q62167
      UniProtKB/TrEMBL
      Q3TQX5
      Related
      ENSMUSP00000000804.6, ENSMUST00000000804.6
      Conserved Domains (4) summary
      cd00268
      Location:182404
      DEADc; DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif ...
      PTZ00110
      Location:57580
      PTZ00110; helicase; Provisional
      pfam00271
      Location:426536
      Helicase_C; Helicase conserved C-terminal domain
      pfam06273
      Location:80172
      eIF-4B; Plant specific eukaryotic initiation factor 4B

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000086.7 Reference GRCm38.p4 C57BL/6J

      Range
      13280496..13293988
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006527566.3XP_006527629.1  ATP-dependent RNA helicase DDX3X isoform X1

      See identical proteins and their annotated locations for XP_006527629.1

      UniProtKB/TrEMBL
      B7ZWF1
      Conserved Domains (4) summary
      cd00268
      Location:181403
      DEADc; DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif ...
      PTZ00110
      Location:56579
      PTZ00110; helicase; Provisional
      pfam00271
      Location:425535
      Helicase_C; Helicase conserved C-terminal domain
      pfam06273
      Location:79171
      eIF-4B; Plant specific eukaryotic initiation factor 4B
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