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    Dhx15 DEAH (Asp-Glu-Ala-His) box polypeptide 15 [ Mus musculus (house mouse) ]

    Gene ID: 13204, updated on 31-Jan-2019

    Summary

    Official Symbol
    Dhx15provided by MGI
    Official Full Name
    DEAH (Asp-Glu-Ala-His) box polypeptide 15provided by MGI
    Primary source
    MGI:MGI:1099786
    See related
    Ensembl:ENSMUSG00000029169
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    DBP1; HRH2; DEAH9; Ddx15; mDEAH9
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 55.8), CNS E14 (RPKM 38.2) and 25 other tissues See more
    Orthologs

    Genomic context

    See Dhx15 in Genome Data Viewer
    Location:
    5; 5 C1
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 5 NC_000071.6 (52150203..52190546, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (52541448..52581758, complement)

    Chromosome 5 - NC_000071.6Genomic Context describing neighboring genes Neighboring gene peroxisome proliferative activated receptor, gamma, coactivator 1 alpha Neighboring gene RIKEN cDNA 9230114K14 gene Neighboring gene predicted gene, 40302 Neighboring gene microRNA 6417 Neighboring gene RIKEN cDNA C130083M11 gene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC117685

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    ATP-dependent 3'-5' RNA helicase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    double-stranded RNA binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    helicase activity IEA
    Inferred from Electronic Annotation
    more info
     
    hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    RNA splicing IEA
    Inferred from Electronic Annotation
    more info
     
    mRNA processing IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    U12-type spliceosomal complex ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with U2-type post-mRNA release spliceosomal complex ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear speck ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15
    Names
    DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 15 (RNA helicase A)
    DEAH box protein 15
    putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15
    NP_001036085.1
    NP_031865.2

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001042620.2NP_001036085.1  pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15 isoform 1

      See identical proteins and their annotated locations for NP_001036085.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) contains an alternate 3' terminal exon, resulting in a different 3' UTR and 3' coding region, compared to variant 2. It encodes isoform 1, which has a shorter and distinct C-terminus, compared to isoform 2.
      Source sequence(s)
      AK043111, AK149869, BY285872
      Consensus CDS
      CCDS80280.1
      UniProtKB/TrEMBL
      Q3UDX4, Q497W9
      Related
      ENSMUSP00000143069.1, ENSMUST00000199321.4
      Conserved Domains (5) summary
      smart00490
      Location:382475
      HELICc; helicase superfamily c-terminal domain
      smart00487
      Location:149322
      DEXDc; DEAD-like helicases superfamily
      smart00847
      Location:545628
      HA2; Helicase associated domain (HA2) Add an annotation
      cd00046
      Location:154295
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      pfam07717
      Location:662701
      OB_NTP_bind; Oligonucleotide/oligosaccharide-binding (OB)-fold
    2. NM_007839.3NP_031865.2  pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15 isoform 2

      See identical proteins and their annotated locations for NP_031865.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) represents the longer transcript and encodes the longer isoform (2).
      Source sequence(s)
      AK145983, AK149869, BP767627, BY285872
      Consensus CDS
      CCDS39085.1
      UniProtKB/Swiss-Prot
      O35286
      UniProtKB/TrEMBL
      Q3UDX4, Q3UKJ6
      Related
      ENSMUSP00000031061.7, ENSMUST00000031061.11
      Conserved Domains (1) summary
      COG1643
      Location:124763
      HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]

    RNA

    1. NR_104311.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate splice site resulting in a shorter transcript, compared to variant 2. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AK145983, AK168835, AK169174, BP767627, BY285872

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000071.6 Reference GRCm38.p4 C57BL/6J

      Range
      52150203..52190546 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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