U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    Ddc dopa decarboxylase [ Mus musculus (house mouse) ]

    Gene ID: 13195, updated on 27-Nov-2024

    Summary

    Official Symbol
    Ddcprovided by MGI
    Official Full Name
    dopa decarboxylaseprovided by MGI
    Primary source
    MGI:MGI:94876
    See related
    Ensembl:ENSMUSG00000020182 AllianceGenome:MGI:94876
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Aadc
    Summary
    Enables aromatic-L-amino-acid decarboxylase activity. Acts upstream of or within gene expression; kidney development; and response to toxic substance. Located in cytoplasm. Is expressed in several structures, including alimentary system; heart; nervous system; respiratory system; and sensory organ. Used to study aromatic L-amino acid decarboxylase deficiency. Human ortholog(s) of this gene implicated in Parkinson's disease; aromatic L-amino acid decarboxylase deficiency; bipolar disorder; inherited metabolic disorder; and nicotine dependence. Orthologous to human DDC (dopa decarboxylase). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in kidney adult (RPKM 29.2), liver adult (RPKM 20.2) and 16 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Ddc in Genome Data Viewer
    Location:
    11 A1; 11 7.09 cM
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (11764101..11848144, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (11814101..11898144, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:11611793-11612034 Neighboring gene STARR-positive B cell enhancer ABC_E5207 Neighboring gene predicted gene 12000 Neighboring gene IKAROS family zinc finger 1 Neighboring gene STARR-positive B cell enhancer ABC_E3931 Neighboring gene STARR-positive B cell enhancer mm9_chr11:11666148-11666448 Neighboring gene STARR-positive B cell enhancer ABC_E6952 Neighboring gene STARR-seq mESC enhancer starr_28598 Neighboring gene fidgetin-like 1 Neighboring gene STARR-seq mESC enhancer starr_28601 Neighboring gene STARR-seq mESC enhancer starr_28602 Neighboring gene predicted gene, 51937 Neighboring gene RIKEN cDNA 1700042O10 gene Neighboring gene STARR-seq mESC enhancer starr_28608 Neighboring gene STARR-seq mESC enhancer starr_28612 Neighboring gene predicted gene, 25058 Neighboring gene VISTA enhancer mm154 Neighboring gene uncharacterized LOC102631979 Neighboring gene VISTA enhancer mm178 Neighboring gene growth factor receptor bound protein 10

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 5-hydroxy-L-tryptophan decarboxylase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables 5-hydroxy-L-tryptophan decarboxylase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables L-dopa decarboxylase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables L-dopa decarboxylase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables amino acid binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables aromatic-L-amino-acid decarboxylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables aromatic-L-amino-acid decarboxylase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables aromatic-L-amino-acid decarboxylase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables enzyme binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables pyridoxal phosphate binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables pyridoxal phosphate binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in aminergic neurotransmitter loading into synaptic vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in amino acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in carboxylic acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in catecholamine metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in dopamine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in dopamine biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within kidney development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within response to toxic substance IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in serotonin biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in serotonin biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in axon ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in synaptic vesicle ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    aromatic-L-amino-acid decarboxylase
    NP_001177377.1
    NP_001404386.1
    NP_001404387.1
    NP_001404388.1
    NP_057881.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001190448.1NP_001177377.1  aromatic-L-amino-acid decarboxylase

      See identical proteins and their annotated locations for NP_001177377.1

      Status: VALIDATED

      Source sequence(s)
      AL596450, AL645803
      Consensus CDS
      CCDS24439.1
      UniProtKB/Swiss-Prot
      O88533
      UniProtKB/TrEMBL
      Q5SUV8
      Related
      ENSMUSP00000136467.2, ENSMUST00000178704.8
      Conserved Domains (1) summary
      pfam00282
      Location:35414
      Pyridoxal_deC; Pyridoxal-dependent decarboxylase conserved domain
    2. NM_001417457.1NP_001404386.1  aromatic-L-amino-acid decarboxylase

      Status: VALIDATED

      Source sequence(s)
      AL596450, AL645803
      UniProtKB/Swiss-Prot
      O88533
      UniProtKB/TrEMBL
      Q5SUV8
    3. NM_001417458.1NP_001404387.1  aromatic-L-amino-acid decarboxylase

      Status: VALIDATED

      Source sequence(s)
      AL596450, AL645803
      UniProtKB/Swiss-Prot
      O88533
      UniProtKB/TrEMBL
      Q5SUV8
    4. NM_001417459.1NP_001404388.1  aromatic-L-amino-acid decarboxylase

      Status: VALIDATED

      Source sequence(s)
      AL596450, AL645803
      UniProtKB/Swiss-Prot
      O88533
      UniProtKB/TrEMBL
      Q5SUV8
    5. NM_016672.5NP_057881.1  aromatic-L-amino-acid decarboxylase

      See identical proteins and their annotated locations for NP_057881.1

      Status: VALIDATED

      Source sequence(s)
      AL596450, AL645803
      Consensus CDS
      CCDS24439.1
      UniProtKB/Swiss-Prot
      O88533
      UniProtKB/TrEMBL
      Q5SUV8
      Related
      ENSMUSP00000105286.3, ENSMUST00000109659.9
      Conserved Domains (1) summary
      pfam00282
      Location:35414
      Pyridoxal_deC; Pyridoxal-dependent decarboxylase conserved domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      11764101..11848144 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)