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    Dbi diazepam binding inhibitor [ Mus musculus (house mouse) ]

    Gene ID: 13167, updated on 7-Aug-2018

    Summary

    Official Symbol
    Dbiprovided by MGI
    Official Full Name
    diazepam binding inhibitorprovided by MGI
    Primary source
    MGI:MGI:94865
    See related
    Ensembl:ENSMUSG00000026385 Vega:OTTMUSG00000021601
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    EP; Acbp; ACBD1; endozepine
    Expression
    Ubiquitous expression in liver E18 (RPKM 440.8), subcutaneous fat pad adult (RPKM 390.0) and 26 other tissues See more
    Orthologs

    Genomic context

    See Dbi in Genome Data Viewer
    Location:
    1; 1 E2.3
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 1 NC_000067.6 (120113280..120121096, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (122009857..122017673, complement)

    Chromosome 1 - NC_000067.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 41937 Neighboring gene predicted gene, 41938 Neighboring gene RIKEN cDNA 3110009E18 gene Neighboring gene STEAP family member 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    General gene information

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    benzodiazepine receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    fatty-acyl-CoA binding ISO
    Inferred from Sequence Orthology
    more info
     
    lipid binding IEA
    Inferred from Electronic Annotation
    more info
     
    long-chain fatty acyl-CoA binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein dimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    behavioral fear response IDA
    Inferred from Direct Assay
    more info
    PubMed 
    glial cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    hair follicle development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    lateral ventricle development IDA
    Inferred from Direct Assay
    more info
    PubMed 
    learning or memory IDA
    Inferred from Direct Assay
    more info
    PubMed 
    long-term synaptic potentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of fatty acid beta-oxidation ISO
    Inferred from Sequence Orthology
    more info
     
    phosphatidylcholine acyl-chain remodeling ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of lipid biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of release of sequestered calcium ion into cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of synaptic transmission, GABAergic ISO
    Inferred from Sequence Orthology
    more info
     
    skin development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    triglyceride metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    contractile fiber ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    mitochondrion HDA PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    perinuclear endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    synaptic vesicle ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    acyl-CoA-binding protein
    Names
    diazepam binding inhibitor, splice form 1b
    NP_001033088.1
    NP_031856.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001037999.2NP_001033088.1  acyl-CoA-binding protein isoform 1

      See identical proteins and their annotated locations for NP_001033088.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AC139867
      Consensus CDS
      CCDS15231.1
      UniProtKB/TrEMBL
      Q4VWZ5
      Related
      ENSMUSP00000114705.2, OTTMUSP00000024100, ENSMUST00000151708.2, OTTMUST00000051290
      Conserved Domains (1) summary
      cd00435
      Location:52134
      ACBP; Acyl CoA binding protein (ACBP) binds thiol esters of long fatty acids and coenzyme A in a one-to-one binding mode with high specificity and affinity. Acyl-CoAs are important intermediates in fatty lipid synthesis and fatty acid degradation and play a ...
    2. NM_007830.4NP_031856.1  acyl-CoA-binding protein isoform 2

      See identical proteins and their annotated locations for NP_031856.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has an alternate 5' exon, as compared to variant 1. The resulting isoform (2) is shorter and has a different N-terminus, as compared to isoform 1.
      Source sequence(s)
      AK020692, AV001592, CJ183794
      Consensus CDS
      CCDS15230.1
      UniProtKB/Swiss-Prot
      P31786
      UniProtKB/TrEMBL
      Q548W7
      Related
      ENSMUSP00000027634.6, OTTMUSP00000024099, ENSMUST00000027634.12, OTTMUST00000051289
      Conserved Domains (1) summary
      cd00435
      Location:286
      ACBP; Acyl CoA binding protein (ACBP) binds thiol esters of long fatty acids and coenzyme A in a one-to-one binding mode with high specificity and affinity. Acyl-CoAs are important intermediates in fatty lipid synthesis and fatty acid degradation and play a ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000067.6 Reference GRCm38.p4 C57BL/6J

      Range
      120113280..120121096 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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