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    Dazl deleted in azoospermia-like [ Mus musculus (house mouse) ]

    Gene ID: 13164, updated on 7-Sep-2021

    Summary

    Official Symbol
    Dazlprovided by MGI
    Official Full Name
    deleted in azoospermia-likeprovided by MGI
    Primary source
    MGI:MGI:1342328
    See related
    Ensembl:ENSMUSG00000010592
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Da; Tpx; Dazh; Tpx-; Tpx2; Daz-l; Dazl1; Dazla; Tpx-2; Daz-like
    Summary
    This gene encodes a member of the depleted in azoospermia-like (DAZL) protein family. Members of this family contain an RNA recognition motif, interact with poly A binding proteins, and may be involved in the initiation of translation. The encoded protein is expressed in the cytoplasm of pluripotent stem cells, and in both male and female germ cells, where it is essential for gametogenesis. Disruption of this gene is associated with infertility. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2013]
    Expression
    Biased expression in testis adult (RPKM 15.0) and ovary adult (RPKM 0.8) See more
    Orthologs
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    Genomic context

    See Dazl in Genome Data Viewer
    Location:
    17 C; 17 25.86 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (50586421..50600648, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (50279393..50293620, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 17 NC_000083.5 (50418719..50432924, complement)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene cDNA sequence AY702103 Neighboring gene predicted gene 4669 Neighboring gene predicted gene, 31015 Neighboring gene predicted gene, 30958 Neighboring gene predicted gene, 54010

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    General gene information

    Markers

    Homology

    Clone Names

    • MGC107400

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables mRNA 3'-UTR binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables mRNA 3'-UTR binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables mRNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables translation activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables translation activator activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables translation activator activity ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    part_of polysome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    deleted in azoospermia-like
    Names
    DAZ-like autosomal
    deleted in azoospermia-like 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001277863.1NP_001264792.1  deleted in azoospermia-like isoform 2

      See identical proteins and their annotated locations for NP_001264792.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2, also known as Dazl_delta8) lacks an in-frame exon in the coding region, compared to variant 1. The encoded isoform (2) is shorter, compared to isoform 1. There are no full-length transcripts supporting this variant; it is supported by data in PMID:23298641, with additional support from the partial transcript AW557186.2.
      Source sequence(s)
      AK014854, AK160855, AL592112, CJ074313
      UniProtKB/Swiss-Prot
      Q64368
      UniProtKB/TrEMBL
      Q3TUC3
      Conserved Domains (2) summary
      COG0724
      Location:33113
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12672
      Location:35116
      RRM_DAZL; RNA recognition motif in vertebrate deleted in azoospermia-like (DAZL) proteins
    2. NM_010021.5NP_034151.3  deleted in azoospermia-like isoform 1

      See identical proteins and their annotated locations for NP_034151.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1, also known as Dazl_FL) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK014854, AK160855, AL592112, CJ074313
      Consensus CDS
      CCDS37649.1
      UniProtKB/Swiss-Prot
      Q64368
      UniProtKB/TrEMBL
      Q3TUC3
      Related
      ENSMUSP00000010736.8, ENSMUST00000010736.9
      Conserved Domains (2) summary
      TIGR01628
      Location:40208
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
      cd12672
      Location:35116
      RRM_DAZL; RNA recognition motif in vertebrate deleted in azoospermia-like (DAZL) proteins

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      50586421..50600648 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006523583.4XP_006523646.1  deleted in azoospermia-like isoform X1

      Conserved Domains (2) summary
      TIGR01628
      Location:150318
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
      cd12672
      Location:145226
      RRM_DAZL; RNA recognition motif in vertebrate deleted in azoospermia-like (DAZL) proteins
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