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    Daxx Fas death domain-associated protein [ Mus musculus (house mouse) ]

    Gene ID: 13163, updated on 2-Oct-2018

    Summary

    Official Symbol
    Daxxprovided by MGI
    Official Full Name
    Fas death domain-associated proteinprovided by MGI
    Primary source
    MGI:MGI:1197015
    See related
    Ensembl:ENSMUSG00000002307 Vega:OTTMUSG00000037068
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Expression
    Ubiquitous expression in testis adult (RPKM 30.0), thymus adult (RPKM 18.9) and 28 other tissues See more
    Orthologs

    Genomic context

    See Daxx in Genome Data Viewer
    Location:
    17 B1; 17 17.98 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 17 NC_000083.6 (33909381..33915590)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 17 NC_000083.5 (34046443..34052534)

    Chromosome 17 - NC_000083.6Genomic Context describing neighboring genes Neighboring gene pluripotency associated transcript 17 Neighboring gene cDNA sequence BC051226 Neighboring gene zinc finger and BTB domain containing 22 Neighboring gene predicted gene, 19412 Neighboring gene TAP binding protein

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC150289

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    JUN kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    SUMO binding ISO
    Inferred from Sequence Orthology
    more info
     
    androgen receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    histone binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    histone binding ISO
    Inferred from Sequence Orthology
    more info
     
    kinesin binding ISO
    Inferred from Sequence Orthology
    more info
     
    p53 binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein N-terminus binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein heterodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein kinase activator activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    transcription coactivator activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    transcription coactivator activity ISO
    Inferred from Sequence Orthology
    more info
     
    transcription corepressor activity ISO
    Inferred from Sequence Orthology
    more info
     
    transcription corepressor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    PML body organization ISO
    Inferred from Sequence Orthology
    more info
     
    androgen receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    apoptotic signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    cellular response to cadmium ion ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to copper ion ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to diamide ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to heat ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to sodium arsenite ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to unfolded protein ISO
    Inferred from Sequence Orthology
    more info
     
    chromatin organization IEA
    Inferred from Electronic Annotation
    more info
     
    chromatin remodeling ISO
    Inferred from Sequence Orthology
    more info
     
    mitotic cytokinesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of myotube differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of transcription, DNA-templated IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    nucleosome assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    nucleosome assembly ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of apoptotic signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of apoptotic signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of histone phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of neuron death ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein localization to chromatin IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of multicellular organism growth IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    Component Evidence Code Pubs
    PML body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    PML body ISO
    Inferred from Sequence Orthology
    more info
     
    XY body ISO
    Inferred from Sequence Orthology
    more info
     
    cell body ISO
    Inferred from Sequence Orthology
    more info
     
    cell cortex ISO
    Inferred from Sequence Orthology
    more info
     
    chromosome IEA
    Inferred from Electronic Annotation
    more info
     
    chromosome, centromeric region ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    heterochromatin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    colocalizes_with heterochromatin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    microtubule ISO
    Inferred from Sequence Orthology
    more info
     
    neuron projection ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear body ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
    PubMed 

    General protein information

    Preferred Names
    death domain-associated protein 6
    Names
    death-domain associated protein

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001199733.1NP_001186662.1  death domain-associated protein 6

      See identical proteins and their annotated locations for NP_001186662.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK145906, BQ176437, CR974462
      Consensus CDS
      CCDS28633.1
      UniProtKB/Swiss-Prot
      O35613
      UniProtKB/TrEMBL
      Q3UKR0
      Related
      ENSMUSP00000128504.2, OTTMUSP00000053217, ENSMUST00000170075.8, OTTMUST00000095363
      Conserved Domains (2) summary
      cd13150
      Location:189393
      DAXX_histone_binding; Histone binding domain of the death-domain associated protein (DAXX)
      pfam03344
      Location:54152
      Daxx; Daxx N-terminal Rassf1C-interacting domain
    2. NM_001355704.1NP_001342633.1  death domain-associated protein 6

      Status: VALIDATED

      Source sequence(s)
      CO041718, CR974462
      Conserved Domains (2) summary
      cd13150
      Location:189393
      DAXX_histone_binding; Histone binding domain of the death-domain associated protein (DAXX)
      pfam03344
      Location:54152
      Daxx; Daxx N-terminal Rassf1C-interacting domain
    3. NM_007829.4NP_031855.3  death domain-associated protein 6

      See identical proteins and their annotated locations for NP_031855.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK145906, BQ176437, CR974462
      Consensus CDS
      CCDS28633.1
      UniProtKB/Swiss-Prot
      O35613
      UniProtKB/TrEMBL
      Q3UKR0
      Related
      ENSMUSP00000078390.7, OTTMUSP00000053214, ENSMUST00000079421.13, OTTMUST00000095360
      Conserved Domains (2) summary
      cd13150
      Location:189393
      DAXX_histone_binding; Histone binding domain of the death-domain associated protein (DAXX)
      pfam03344
      Location:54152
      Daxx; Daxx N-terminal Rassf1C-interacting domain

    RNA

    1. NR_149750.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      CO041718, CR974462

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000083.6 Reference GRCm38.p4 C57BL/6J

      Range
      33909381..33915590
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006523582.2XP_006523645.1  death domain-associated protein 6 isoform X1

      See identical proteins and their annotated locations for XP_006523645.1

      UniProtKB/Swiss-Prot
      O35613
      UniProtKB/TrEMBL
      Q3UKR0
      Conserved Domains (2) summary
      cd13150
      Location:189393
      DAXX_histone_binding; Histone binding domain of the death-domain associated protein (DAXX)
      pfam03344
      Location:54152
      Daxx; Daxx N-terminal Rassf1C-interacting domain
    2. XM_006523581.2XP_006523644.1  death domain-associated protein 6 isoform X1

      See identical proteins and their annotated locations for XP_006523644.1

      UniProtKB/Swiss-Prot
      O35613
      UniProtKB/TrEMBL
      Q3UKR0
      Related
      ENSMUSP00000134158.1, OTTMUSP00000053218, ENSMUST00000174146.1, OTTMUST00000095365
      Conserved Domains (2) summary
      cd13150
      Location:189393
      DAXX_histone_binding; Histone binding domain of the death-domain associated protein (DAXX)
      pfam03344
      Location:54152
      Daxx; Daxx N-terminal Rassf1C-interacting domain
    3. XM_006523580.2XP_006523643.1  death domain-associated protein 6 isoform X1

      UniProtKB/Swiss-Prot
      O35613
      UniProtKB/TrEMBL
      Q3UKR0
      Conserved Domains (2) summary
      cd13150
      Location:189393
      DAXX_histone_binding; Histone binding domain of the death-domain associated protein (DAXX)
      pfam03344
      Location:54152
      Daxx; Daxx N-terminal Rassf1C-interacting domain

    RNA

    1. XR_385278.1 RNA Sequence

    Reference GRCm38.p4 129X1/SvJ

    Genomic

    1. NT_039662.3 Reference GRCm38.p4 129X1/SvJ

      Range
      158213..164358
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCm38.p4 NOD/MrkTac

    Genomic

    1. NT_187027.1 Reference GRCm38.p4 NOD/MrkTac

      Range
      218275..224377
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCm38.p4 NOD/ShiLtJ

    Genomic

    1. NT_187004.1 Reference GRCm38.p4 NOD/ShiLtJ

      Range
      218387..224489
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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