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    Daxx Fas death domain-associated protein [ Mus musculus (house mouse) ]

    Gene ID: 13163, updated on 23-Jun-2021

    Summary

    Official Symbol
    Daxxprovided by MGI
    Official Full Name
    Fas death domain-associated proteinprovided by MGI
    Primary source
    MGI:MGI:1197015
    See related
    Ensembl:ENSMUSG00000002307
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Expression
    Ubiquitous expression in testis adult (RPKM 30.0), thymus adult (RPKM 18.9) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Daxx in Genome Data Viewer
    Location:
    17 B1; 17 17.98 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (34128379..34134564)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (33909404..33915590)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 17 NC_000083.5 (34046443..34052534)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene small integral membrane protein 40 Neighboring gene cDNA sequence BC051226 Neighboring gene zinc finger and BTB domain containing 22 Neighboring gene predicted gene, 19412 Neighboring gene TAP binding protein

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (4)  1 citation
    • Endonuclease-mediated (1) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC150289

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables JUN kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables androgen receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables histone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables histone binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables histone binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables kinesin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables p53 binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein N-terminus binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein kinase activator activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables sumo-dependent protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables transcription coactivator activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables transcription coactivator activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables transcription corepressor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables transcription corepressor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables transcription corepressor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables transcription factor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables transcription regulator inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in PML body organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in androgen receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within apoptotic signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in cellular response to cadmium ion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to copper ion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to diamide ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to heat ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to sodium arsenite ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to unfolded protein ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within chromatin organization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in chromatin remodeling ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within mitotic cytokinesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of myotube differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of transcription, DNA-templated IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of transcription, DNA-templated IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in nucleosome assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in nucleosome assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in nucleosome assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of apoptotic signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of apoptotic signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of histone phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of neuron death ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein localization to chromatin IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within regulation of multicellular organism growth IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in PML body IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in PML body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in PML body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in XY body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell cortex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in chromosome, centromeric region ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    colocalizes_with heterochromatin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in heterochromatin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in microtubule ISO
    Inferred from Sequence Orthology
    more info
     
    located_in neuron projection ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    PubMed 

    General protein information

    Preferred Names
    death domain-associated protein 6
    Names
    death-domain associated protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001199733.1NP_001186662.1  death domain-associated protein 6

      See identical proteins and their annotated locations for NP_001186662.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK145906, BQ176437, CR974462
      Consensus CDS
      CCDS28633.1
      UniProtKB/Swiss-Prot
      O35613
      UniProtKB/TrEMBL
      Q3UKR0
      Related
      ENSMUSP00000128504.3, ENSMUST00000170075.9
      Conserved Domains (2) summary
      cd13150
      Location:189393
      DAXX_histone_binding; Histone binding domain of the death-domain associated protein (DAXX)
      pfam03344
      Location:56150
      Daxx; Daxx N-terminal Rassf1C-interacting domain
    2. NM_001355704.1NP_001342633.1  death domain-associated protein 6

      Status: VALIDATED

      Source sequence(s)
      CO041718, CR974462
      Consensus CDS
      CCDS28633.1
      Conserved Domains (2) summary
      cd13150
      Location:189393
      DAXX_histone_binding; Histone binding domain of the death-domain associated protein (DAXX)
      pfam03344
      Location:56150
      Daxx; Daxx N-terminal Rassf1C-interacting domain
    3. NM_007829.4NP_031855.3  death domain-associated protein 6

      See identical proteins and their annotated locations for NP_031855.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK145906, BQ176437, CR974462
      Consensus CDS
      CCDS28633.1
      UniProtKB/Swiss-Prot
      O35613
      UniProtKB/TrEMBL
      Q3UKR0
      Related
      ENSMUSP00000078390.8, ENSMUST00000079421.15
      Conserved Domains (2) summary
      cd13150
      Location:189393
      DAXX_histone_binding; Histone binding domain of the death-domain associated protein (DAXX)
      pfam03344
      Location:56150
      Daxx; Daxx N-terminal Rassf1C-interacting domain

    RNA

    1. NR_149750.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      CO041718, CR974462

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      34128379..34134564
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006523582.4XP_006523645.1  death domain-associated protein 6 isoform X1

      See identical proteins and their annotated locations for XP_006523645.1

      UniProtKB/Swiss-Prot
      O35613
      UniProtKB/TrEMBL
      Q3UKR0
      Conserved Domains (2) summary
      cd13150
      Location:189393
      DAXX_histone_binding; Histone binding domain of the death-domain associated protein (DAXX)
      pfam03344
      Location:56150
      Daxx; Daxx N-terminal Rassf1C-interacting domain
    2. XM_006523581.4XP_006523644.1  death domain-associated protein 6 isoform X1

      See identical proteins and their annotated locations for XP_006523644.1

      UniProtKB/Swiss-Prot
      O35613
      UniProtKB/TrEMBL
      Q3UKR0
      Conserved Domains (2) summary
      cd13150
      Location:189393
      DAXX_histone_binding; Histone binding domain of the death-domain associated protein (DAXX)
      pfam03344
      Location:56150
      Daxx; Daxx N-terminal Rassf1C-interacting domain
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