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    Dapk3 death-associated protein kinase 3 [ Mus musculus (house mouse) ]

    Gene ID: 13144, updated on 31-Jan-2019

    Summary

    Official Symbol
    Dapk3provided by MGI
    Official Full Name
    death-associated protein kinase 3provided by MGI
    Primary source
    MGI:MGI:1203520
    See related
    Ensembl:ENSMUSG00000034974
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    dlk; ZIPK
    Expression
    Ubiquitous expression in ovary adult (RPKM 67.6), duodenum adult (RPKM 59.4) and 28 other tissues See more
    Orthologs

    Genomic context

    See Dapk3 in Genome Data Viewer
    Location:
    10 C1; 10 39.72 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 10 NC_000076.6 (81182987..81193197)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 10 NC_000076.5 (80645752..80655942)

    Chromosome 10 - NC_000076.6Genomic Context describing neighboring genes Neighboring gene protein inhibitor of activated STAT 4 Neighboring gene small nucleolar RNA, C/D box 37 Neighboring gene eukaryotic translation elongation factor 2 Neighboring gene ataxia, cerebellar, Cayman type, opposite strand Neighboring gene nicotinamide riboside kinase 2 Neighboring gene ataxia, cerebellar, Cayman type

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    ATP binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ATP binding ISO
    Inferred from Sequence Orthology
    more info
     
    Rho GTPase binding ISO
    Inferred from Sequence Orthology
    more info
     
    identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    kinase activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    leucine zipper domain binding ISO
    Inferred from Sequence Orthology
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein C-terminus binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    apoptotic signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    apoptotic signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    cellular response to interferon-gamma IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cellular response to interferon-gamma ISO
    Inferred from Sequence Orthology
    more info
     
    chromatin organization IEA
    Inferred from Electronic Annotation
    more info
     
    intracellular signal transduction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    intracellular signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of translation ISO
    Inferred from Sequence Orthology
    more info
     
    phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of canonical Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of extrinsic apoptotic signaling pathway in absence of ligand ISO
    Inferred from Sequence Orthology
    more info
     
    protein autophosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of actin cytoskeleton reorganization ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of cell shape IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of focal adhesion assembly ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of myosin II filament organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    PML body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    actin filament ISO
    Inferred from Sequence Orthology
    more info
     
    chromosome IEA
    Inferred from Electronic Annotation
    more info
     
    chromosome, centromeric region IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    membrane raft ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    death-associated protein kinase 3
    Names
    DAP kinase 3
    DAP-like kinase
    MYPT1 kinase
    ZIP-kinase
    death-associated kinase 3
    NP_001177402.1
    NP_001177403.2
    NP_031854.1
    XP_006513257.1
    XP_006513258.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001190473.1NP_001177402.1  death-associated protein kinase 3 isoform b

      See identical proteins and their annotated locations for NP_001177402.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2 and 3 both encode the same isoform (b).
      Source sequence(s)
      AC155932
      Consensus CDS
      CCDS24045.1
      UniProtKB/Swiss-Prot
      O54784
      UniProtKB/TrEMBL
      Q05A21
      Related
      ENSMUSP00000035962.6, ENSMUST00000047665.6
      Conserved Domains (1) summary
      cd14105
      Location:7275
      STKc_DAPK; Catalytic domain of the Serine/Threonine Kinase, Death-Associated Protein Kinase
    2. NM_001190474.1NP_001177403.2  death-associated protein kinase 3 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a).
      Source sequence(s)
      AC155932
      Conserved Domains (2) summary
      smart00220
      Location:30292
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14105
      Location:24292
      STKc_DAPK; Catalytic domain of the Serine/Threonine Kinase, Death-Associated Protein Kinase
    3. NM_007828.2NP_031854.1  death-associated protein kinase 3 isoform b

      See identical proteins and their annotated locations for NP_031854.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2 and 3 both encode the same isoform (b).
      Source sequence(s)
      AC155932
      Consensus CDS
      CCDS24045.1
      UniProtKB/Swiss-Prot
      O54784
      UniProtKB/TrEMBL
      Q05A21
      Related
      ENSMUSP00000151577.1, ENSMUST00000219850.1
      Conserved Domains (1) summary
      cd14105
      Location:7275
      STKc_DAPK; Catalytic domain of the Serine/Threonine Kinase, Death-Associated Protein Kinase

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000076.6 Reference GRCm38.p4 C57BL/6J

      Range
      81182987..81193197
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006513194.2XP_006513257.1  death-associated protein kinase 3 isoform X1

      Conserved Domains (2) summary
      smart00220
      Location:30283
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl21453
      Location:24285
      PKc_like; Protein Kinases, catalytic domain
    2. XM_006513195.2XP_006513258.1  death-associated protein kinase 3 isoform X2

      See identical proteins and their annotated locations for XP_006513258.1

      UniProtKB/Swiss-Prot
      O54784
      UniProtKB/TrEMBL
      Q05A21
      Conserved Domains (1) summary
      cd14105
      Location:7275
      STKc_DAPK; Catalytic domain of the Serine/Threonine Kinase, Death-Associated Protein Kinase
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