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    Dapk3 death-associated protein kinase 3 [ Mus musculus (house mouse) ]

    Gene ID: 13144, updated on 5-Sep-2021

    Summary

    Official Symbol
    Dapk3provided by MGI
    Official Full Name
    death-associated protein kinase 3provided by MGI
    Primary source
    MGI:MGI:1203520
    See related
    Ensembl:ENSMUSG00000034974
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    dlk; ZIPK
    Expression
    Ubiquitous expression in ovary adult (RPKM 67.6), duodenum adult (RPKM 59.4) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Dapk3 in Genome Data Viewer
    Location:
    10 C1; 10 39.72 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (81018821..81029031)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (81182987..81193197)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 10 NC_000076.5 (80645752..80655942)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene protein inhibitor of activated STAT 4 Neighboring gene small nucleolar RNA, C/D box 37 Neighboring gene eukaryotic translation elongation factor 2 Neighboring gene ataxia, cerebellar, Cayman type, opposite strand Neighboring gene nicotinamide riboside kinase 2 Neighboring gene ataxia, cerebellar, Cayman type

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Targeted (1) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables ATP binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables kinase activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    enables leucine zipper domain binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein C-terminus binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables small GTPase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within apoptotic signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within apoptotic signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in cellular response to interferon-gamma IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cellular response to interferon-gamma ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within chromatin organization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in intracellular signal transduction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in intracellular signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of translation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of canonical Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of extrinsic apoptotic signaling pathway in absence of ligand ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein autophosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of actin cytoskeleton reorganization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of cell shape IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of focal adhesion assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of myosin II filament organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in PML body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in actin filament ISO
    Inferred from Sequence Orthology
    more info
     
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in chromosome, centromeric region IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    located_in membrane raft ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    death-associated protein kinase 3
    Names
    DAP kinase 3
    DAP-like kinase
    MYPT1 kinase
    ZIP-kinase
    death-associated kinase 3
    NP_001177402.1
    NP_001177403.2
    NP_031854.1
    XP_006513257.1
    XP_006513258.1
    XP_030100726.1
    XP_036011469.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001190473.1NP_001177402.1  death-associated protein kinase 3 isoform b

      See identical proteins and their annotated locations for NP_001177402.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2 and 3 both encode the same isoform (b).
      Source sequence(s)
      AC155932
      Consensus CDS
      CCDS24045.1
      UniProtKB/Swiss-Prot
      O54784
      UniProtKB/TrEMBL
      Q05A21
      Related
      ENSMUSP00000035962.7, ENSMUST00000047665.7
      Conserved Domains (1) summary
      cd14105
      Location:7275
      STKc_DAPK; Catalytic domain of the Serine/Threonine Kinase, Death-Associated Protein Kinase
    2. NM_001190474.1NP_001177403.2  death-associated protein kinase 3 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a).
      Source sequence(s)
      AC155932
      Conserved Domains (2) summary
      smart00220
      Location:30292
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14105
      Location:24292
      STKc_DAPK; Catalytic domain of the Serine/Threonine Kinase, Death-Associated Protein Kinase
    3. NM_007828.2NP_031854.1  death-associated protein kinase 3 isoform b

      See identical proteins and their annotated locations for NP_031854.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2 and 3 both encode the same isoform (b).
      Source sequence(s)
      AC155932
      Consensus CDS
      CCDS24045.1
      UniProtKB/Swiss-Prot
      O54784
      UniProtKB/TrEMBL
      Q05A21
      Related
      ENSMUSP00000151577.2, ENSMUST00000219850.2
      Conserved Domains (1) summary
      cd14105
      Location:7275
      STKc_DAPK; Catalytic domain of the Serine/Threonine Kinase, Death-Associated Protein Kinase

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      81018821..81029031
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006513194.2XP_006513257.1  death-associated protein kinase 3 isoform X1

      Conserved Domains (1) summary
      cl21453
      Location:24285
      PKc_like; Protein Kinases, catalytic domain
    2. XM_030244866.1XP_030100726.1  death-associated protein kinase 3 isoform X3

      Conserved Domains (1) summary
      cl21453
      Location:7268
      PKc_like; Protein Kinases, catalytic domain
    3. XM_006513195.4XP_006513258.1  death-associated protein kinase 3 isoform X2

      See identical proteins and their annotated locations for XP_006513258.1

      UniProtKB/Swiss-Prot
      O54784
      UniProtKB/TrEMBL
      Q05A21
      Conserved Domains (1) summary
      cd14105
      Location:7275
      STKc_DAPK; Catalytic domain of the Serine/Threonine Kinase, Death-Associated Protein Kinase
    4. XM_036155576.1XP_036011469.1  death-associated protein kinase 3 isoform X3

      Conserved Domains (1) summary
      cl21453
      Location:7268
      PKc_like; Protein Kinases, catalytic domain
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