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    Dao D-amino acid oxidase [ Mus musculus (house mouse) ]

    Gene ID: 13142, updated on 17-Jul-2024

    Summary

    Official Symbol
    Daoprovided by MGI
    Official Full Name
    D-amino acid oxidaseprovided by MGI
    Primary source
    MGI:MGI:94859
    See related
    Ensembl:ENSMUSG00000042096 AllianceGenome:MGI:94859
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    DAAO; Dao1; DAMOX; Dao-1
    Summary
    Enables D-amino-acid oxidase activity and FAD binding activity. Involved in D-alanine catabolic process. Acts upstream of or within leucine metabolic process. Predicted to be located in cytosol and peroxisomal membrane. Predicted to be active in cytoplasm. Predicted to colocalize with mitochondrial outer membrane. Is expressed in metanephros; renal cortex; ureter; and urinary system. Human ortholog(s) of this gene implicated in schizophrenia. Orthologous to human DAO (D-amino acid oxidase). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in kidney adult (RPKM 130.9), duodenum adult (RPKM 16.0) and 1 other tissue See more
    Orthologs
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    Genomic context

    See Dao in Genome Data Viewer
    Location:
    5 F; 5 55.93 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (114137696..114163736)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (113999635..114025675)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 22056 Neighboring gene slingshot protein phosphatase 1 Neighboring gene STARR-seq mESC enhancer starr_14062 Neighboring gene predicted gene, 52826 Neighboring gene SV2 related protein Neighboring gene predicted gene 16108 Neighboring gene ubiquitin specific peptidase 30 Neighboring gene legumain pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables D-amino-acid dehydrogenase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables D-amino-acid oxidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables D-amino-acid oxidase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables D-amino-acid oxidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables FAD binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables FAD binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in D-alanine catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in D-alanine catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in D-alanine catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in D-amino acid catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in D-amino acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in D-serine catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in D-serine catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in D-serine metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within L-leucine metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in digestion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in dopamine biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in dopamine biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in killing by host of symbiont cells IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in neutrophil-mediated killing of gram-negative bacterium IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in proline catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in proline catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    colocalizes_with mitochondrial outer membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in peroxisomal matrix IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in peroxisomal matrix ISO
    Inferred from Sequence Orthology
    more info
     
    located_in peroxisome IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    D-amino-acid oxidase
    Names
    D-amino acid oxidase 1
    NP_001273325.1
    NP_001273326.1
    NP_034148.2
    XP_006530224.1
    XP_006530225.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001286396.1NP_001273325.1  D-amino-acid oxidase isoform 1

      See identical proteins and their annotated locations for NP_001273325.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein (isoform 1).
      Source sequence(s)
      AC145559
      Consensus CDS
      CCDS19557.1
      UniProtKB/Swiss-Prot
      A0A0R4J203, P18894, Q64465, Q8VCW7
      Related
      ENSMUSP00000125588.2, ENSMUST00000161610.6
      Conserved Domains (2) summary
      pfam01266
      Location:35327
      DAO; FAD dependent oxidoreductase
      cl21454
      Location:124
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    2. NM_001286397.1NP_001273326.1  D-amino-acid oxidase isoform 2

      See identical proteins and their annotated locations for NP_001273326.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an alternate exon in the 3' coding region compared to variant 1. The resulting protein (isoform 2) is shorter and has a distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AC145559
      Consensus CDS
      CCDS71641.1
      UniProtKB/TrEMBL
      Q91WH3
      Related
      ENSMUSP00000083792.5, ENSMUST00000086599.11
      Conserved Domains (1) summary
      pfam01266
      Location:2226
      DAO; FAD dependent oxidoreductase
    3. NM_010018.3NP_034148.2  D-amino-acid oxidase isoform 1

      See identical proteins and their annotated locations for NP_034148.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer protein (isoform 1). Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC145559, AK134813, AW492600, BU755879
      Consensus CDS
      CCDS19557.1
      UniProtKB/Swiss-Prot
      A0A0R4J203, P18894, Q64465, Q8VCW7
      Related
      ENSMUSP00000107911.3, ENSMUST00000112292.9
      Conserved Domains (2) summary
      pfam01266
      Location:35327
      DAO; FAD dependent oxidoreductase
      cl21454
      Location:124
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      114137696..114163736
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006530162.4XP_006530225.1  D-amino-acid oxidase isoform X1

      See identical proteins and their annotated locations for XP_006530225.1

      UniProtKB/Swiss-Prot
      A0A0R4J203, P18894, Q64465, Q8VCW7
      Conserved Domains (2) summary
      pfam01266
      Location:35327
      DAO; FAD dependent oxidoreductase
      cl21454
      Location:124
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    2. XM_006530161.2XP_006530224.1  D-amino-acid oxidase isoform X1

      See identical proteins and their annotated locations for XP_006530224.1

      UniProtKB/Swiss-Prot
      A0A0R4J203, P18894, Q64465, Q8VCW7
      Conserved Domains (2) summary
      pfam01266
      Location:35327
      DAO; FAD dependent oxidoreductase
      cl21454
      Location:124
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins