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    Dab2 disabled 2, mitogen-responsive phosphoprotein [ Mus musculus (house mouse) ]

    Gene ID: 13132, updated on 12-Sep-2021

    Summary

    Official Symbol
    Dab2provided by MGI
    Official Full Name
    disabled 2, mitogen-responsive phosphoproteinprovided by MGI
    Primary source
    MGI:MGI:109175
    See related
    Ensembl:ENSMUSG00000022150
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    p9; p96; Doc2; Doc-2; AA960054; AI957090; D15Wsu122; D15Wsu122e; 5730435J12Rik; D630005B22Rik
    Expression
    Broad expression in kidney adult (RPKM 58.2), placenta adult (RPKM 56.8) and 17 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Dab2 in Genome Data Viewer
    Location:
    15 A1; 15 2.15 cM
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (6329269..6470196)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (6299788..6440715)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 15 NC_000081.5 (6249789..6390712)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 41259 Neighboring gene breast cancer metastasis-suppressor 1-like protein pseudogene Neighboring gene predicted gene, 23139 Neighboring gene predicted gene 16311 Neighboring gene DEAD (Asp-Glu-Ala-Asp) box polypeptide 18 pseudogene Neighboring gene complement component 9 Neighboring gene FYN binding protein Neighboring gene predicted gene 2245 Neighboring gene prohibitin pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables AP-2 adaptor complex binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables SMAD binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables cargo receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables cargo receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables clathrin adaptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables clathrin adaptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables clathrin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables integrin binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables low-density lipoprotein particle receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables phosphatidylinositol binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables phosphatidylinositol-4,5-bisphosphate binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein C-terminus binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within cell morphogenesis involved in differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cellular response to epidermal growth factor stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to transforming growth factor beta stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in clathrin coat assembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in clathrin coat assembly ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within endocytosis IEA
    Inferred from Electronic Annotation
    more info
     
    NOT acts_upstream_of_or_within endoderm development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within endoderm development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within excretion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within hematopoietic stem cell proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within in utero embryonic development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in leading edge cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within myeloid cell differentiation IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in negative regulation of ERK1 and ERK2 cascade ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of androgen receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of canonical Wnt signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in negative regulation of canonical Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cell growth ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of epithelial cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of extrinsic apoptotic signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of neuron projection development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of protein localization to plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of protein localization to plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within pinocytosis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of JNK cascade IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of SMAD protein signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of Wnt signaling pathway, planar cell polarity pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of aldosterone biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of aldosterone secretion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cell adhesion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of cell adhesion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of clathrin-dependent endocytosis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of clathrin-dependent endocytosis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of early endosome to late endosome transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in positive regulation of endocytosis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of epithelial to mesenchymal transition IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of epithelial to mesenchymal transition ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of integrin-mediated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of pathway-restricted SMAD protein phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of pathway-restricted SMAD protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of receptor internalization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of receptor recycling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of substrate adhesion-dependent cell spreading IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of substrate adhesion-dependent cell spreading IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of substrate adhesion-dependent cell spreading ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of transcription elongation from RNA polymerase II promoter IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of transforming growth factor beta receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in receptor-mediated endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within receptor-mediated endocytosis IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    involved_in regulation of Rho-dependent protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to steroid hormone ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of clathrin coat of coated pit IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in clathrin-coated pit ISO
    Inferred from Sequence Orthology
    more info
     
    located_in clathrin-coated vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in clathrin-coated vesicle membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
     
    located_in fibrillar center ISO
    Inferred from Sequence Orthology
    more info
     
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    disabled homolog 2
    Names
    adaptor molecule disabled-2
    differentially expressed in ovarian carcinoma 2
    mitogen-responsive phosphoprotein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001008702.2NP_001008702.1  disabled homolog 2 isoform b

      See identical proteins and their annotated locations for NP_001008702.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and lacks an alternate in-frame exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.
      Source sequence(s)
      AC105324, AK162851, AK165519, BB848282
      Consensus CDS
      CCDS37030.1
      UniProtKB/Swiss-Prot
      P98078
      UniProtKB/TrEMBL
      Q3TN55, Q3TRE6
      Related
      ENSMUSP00000077166.7, ENSMUST00000078019.13
      Conserved Domains (1) summary
      cd01215
      Location:35171
      PTB_Dab; Disabled (Dab) Phosphotyrosine-binding domain
    2. NM_001037905.3NP_001032994.1  disabled homolog 2 isoform b

      See identical proteins and their annotated locations for NP_001032994.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a. Variants 2 and 3 both encode isoform b.
      Source sequence(s)
      AC105324, AK162851, AK165519, BB856968, CB952492
      Consensus CDS
      CCDS37030.1
      UniProtKB/Swiss-Prot
      P98078
      UniProtKB/TrEMBL
      Q3TN55, Q3TRE6
      Related
      ENSMUSP00000106291.3, ENSMUST00000110663.9
      Conserved Domains (1) summary
      cd01215
      Location:35171
      PTB_Dab; Disabled (Dab) Phosphotyrosine-binding domain
    3. NM_001102400.1NP_001095870.1  disabled homolog 2 isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks two alternate in-frame exons compared to variant 1. The resulting isoform (c) has the same N- and C-termini but is shorter compared to isoform a.
      Source sequence(s)
      AC105324, AK162744, BB856968, CB952492
      Consensus CDS
      CCDS49576.1
      UniProtKB/TrEMBL
      E9PX84, Q3TRI2
      Related
      ENSMUSP00000124589.2, ENSMUST00000161812.8
      Conserved Domains (1) summary
      cd01215
      Location:35171
      PTB_Dab; Disabled (Dab) Phosphotyrosine-binding domain
    4. NM_001310446.1NP_001297375.1  disabled homolog 2 isoform d

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) lacks an internal in-frame exon compared to variant 1. The resulting isoform (d) is shorter missing an internal protein segment compared to isoform a.
      Source sequence(s)
      AC105324, AK162744, AK162851, AK165519, AK168375, BB856968, BG072606, CD348957, CD741855
      Consensus CDS
      CCDS79357.1
      UniProtKB/TrEMBL
      E9QL31, Q3TN55, Q3TRE6, Q3TRI2
      Related
      ENSMUSP00000106292.3, ENSMUST00000110664.9
      Conserved Domains (1) summary
      cd01215
      Location:35171
      PTB_Dab; Disabled (Dab) Phosphotyrosine-binding domain
    5. NM_023118.5NP_075607.2  disabled homolog 2 isoform a

      See identical proteins and their annotated locations for NP_075607.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
      Source sequence(s)
      AC105324, AK162851, AK165519, BB856968, CB598046, CB952492, CD348957
      Consensus CDS
      CCDS37029.1
      UniProtKB/Swiss-Prot
      P98078
      UniProtKB/TrEMBL
      A0A0R4J104, Q3TN55, Q3TRE6
      Related
      ENSMUSP00000079689.6, ENSMUST00000080880.12
      Conserved Domains (2) summary
      PHA03247
      Location:288608
      PHA03247; large tegument protein UL36; Provisional
      cd01215
      Location:35171
      PTB_Dab; Disabled (Dab) Phosphotyrosine-binding domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      6329269..6470196
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011245324.1XP_011243626.1  disabled homolog 2 isoform X1

      See identical proteins and their annotated locations for XP_011243626.1

      UniProtKB/Swiss-Prot
      P98078
      UniProtKB/TrEMBL
      A0A0R4J104
      Conserved Domains (2) summary
      PHA03247
      Location:288608
      PHA03247; large tegument protein UL36; Provisional
      cd01215
      Location:35171
      PTB_Dab; Disabled (Dab) Phosphotyrosine-binding domain
    2. XM_030248313.2XP_030104173.1  disabled homolog 2 isoform X3

      Related
      ENSMUSP00000124478.2, ENSMUST00000161040.8
      Conserved Domains (1) summary
      cd01215
      Location:35171
      PTB_Dab; Disabled (Dab) Phosphotyrosine-binding domain
    3. XM_017316424.3XP_017171913.1  disabled homolog 2 isoform X1

      UniProtKB/Swiss-Prot
      P98078
      UniProtKB/TrEMBL
      A0A0R4J104
      Conserved Domains (2) summary
      PHA03247
      Location:288608
      PHA03247; large tegument protein UL36; Provisional
      cd01215
      Location:35171
      PTB_Dab; Disabled (Dab) Phosphotyrosine-binding domain
    4. XM_030248312.2XP_030104172.1  disabled homolog 2 isoform X2

      Conserved Domains (1) summary
      cd01215
      Location:35171
      PTB_Dab; Disabled (Dab) Phosphotyrosine-binding domain
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