Format

Send to:

Choose Destination
    • Showing Current items.

    Celf1 CUGBP, Elav-like family member 1 [ Mus musculus (house mouse) ]

    Gene ID: 13046, updated on 5-Mar-2019

    Summary

    Official Symbol
    Celf1provided by MGI
    Official Full Name
    CUGBP, Elav-like family member 1provided by MGI
    Primary source
    MGI:MGI:1342295
    See related
    Ensembl:ENSMUSG00000005506
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CUGBP; NAB50; CUG-BP; Cugbp1; HNAB50; Brunol2; CUG-BP1; AA407467; D2Wsu101e; 1600010O03Rik
    Expression
    Ubiquitous expression in CNS E18 (RPKM 28.2), whole brain E14.5 (RPKM 28.2) and 28 other tissues See more
    Orthologs

    Genomic context

    See Celf1 in Genome Data Viewer
    Location:
    2 E1; 2 50.44 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 2 NC_000068.7 (90940387..91019497)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (90780615..90857212)

    Chromosome 2 - NC_000068.7Genomic Context describing neighboring genes Neighboring gene kelch repeat and BTB (POZ) domain containing 4 Neighboring gene protein tyrosine phosphatase, mitochondrial 1 Neighboring gene 60S acidic ribosomal protein P1 pseudogene Neighboring gene uncharacterized LOC102632821 Neighboring gene receptor-associated protein of the synapse

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2)  1 citation
    • Endonuclease-mediated (1) 

    Pathways from BioSystems

    • Adipogenesis genes, organism-specific biosystem (from WikiPathways)
      Adipogenesis genes, organism-specific biosystemThe different classes of factors involved in adipogenesis are shown. Adipogenesis is the process by which fat cells differentiate from predadipocytes to adipocytes (fat cells). Adipose tissue, compos...
    • mRNA processing, organism-specific biosystem (from WikiPathways)
      mRNA processing, organism-specific biosystemAdapted from Reactome, see: [http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_1675.1 REACT 1675.1] This process describes the conversion of precursor messenger RNA into mature messenge...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
     
    translation initiation factor binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    RNA splicing IEA
    Inferred from Electronic Annotation
    more info
     
    mRNA processing IEA
    Inferred from Electronic Annotation
    more info
     
    mRNA splice site selection IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    mRNA splice site selection IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of multicellular organism growth IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of alternative mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    spermatid development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm TAS
    Traceable Author Statement
    more info
    PubMed 
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus TAS
    Traceable Author Statement
    more info
    PubMed 
    ribonucleoprotein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    CUGBP Elav-like family member 1
    Names
    50 kDa nuclear polyadenylated RNA-binding protein
    CELF-1
    CUG triplet repeat RNA-binding protein 1
    CUG-BP- and ETR-3-like factor 1
    EDEN-BP homolog
    RNA-binding protein BRUNOL-2
    brain protein F41
    bruno-like protein 2
    deadenylation factor CUG-BP
    deadenylation factor EDEN-BP
    embryo deadenylation element-binding protein homolog

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001244891.1NP_001231820.1  CUGBP Elav-like family member 1 isoform 2

      See identical proteins and their annotated locations for NP_001231820.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) has an alternate exon in the 5' region, which results in a downstream AUG start codon, and has an additional segment in the 3' UTR, compared to variant 1. The resulting isoform (2) is shorter at the N-terminus, compared to isoform 1.
      Source sequence(s)
      AK143698, AL672241, BU056861, CF745326, CX210403
      Consensus CDS
      CCDS16421.1
      UniProtKB/Swiss-Prot
      P28659
      Related
      ENSMUSP00000136109.1, ENSMUST00000177642.7
      Conserved Domains (3) summary
      cd12631
      Location:1598
      RRM1_CELF1_2_Bruno; RNA recognition motif 1 in CUGBP Elav-like family member CELF-1, CELF-2, Drosophila melanogaster Bruno protein and similar proteins
      cd12634
      Location:107187
      RRM2_CELF1_2; RNA recognition motif 2 in CUGBP Elav-like family member CELF-1, CELF-2 and similar proteins
      cd12638
      Location:394485
      RRM3_CELF1_2; RNA recognition motif 3 in CUGBP Elav-like family member CELF-1, CELF-2 and similar proteins
    2. NM_001244903.1NP_001231832.1  CUGBP Elav-like family member 1 isoform 2

      See identical proteins and their annotated locations for NP_001231832.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks an exon in the 5' region, which results in a downstream AUG start codon, and has an additional segment in the 3' UTR, compared to variant 1. The resulting isoform (2) is shorter at the N-terminus, compared to isoform 1.
      Source sequence(s)
      AK143698, AL672241, BU056861, BY719033, CX210403
      Consensus CDS
      CCDS16421.1
      UniProtKB/Swiss-Prot
      P28659
      Related
      ENSMUSP00000070438.7, ENSMUST00000068747.13
      Conserved Domains (3) summary
      cd12631
      Location:1598
      RRM1_CELF1_2_Bruno; RNA recognition motif 1 in CUGBP Elav-like family member CELF-1, CELF-2, Drosophila melanogaster Bruno protein and similar proteins
      cd12634
      Location:107187
      RRM2_CELF1_2; RNA recognition motif 2 in CUGBP Elav-like family member CELF-1, CELF-2 and similar proteins
      cd12638
      Location:394485
      RRM3_CELF1_2; RNA recognition motif 3 in CUGBP Elav-like family member CELF-1, CELF-2 and similar proteins
    3. NM_017368.3NP_059064.2  CUGBP Elav-like family member 1 isoform 1

      See identical proteins and their annotated locations for NP_059064.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AF314172, AK143698, AL672241, BU056861, CF171545, CJ092744, CX210403
      Consensus CDS
      CCDS16420.1
      UniProtKB/Swiss-Prot
      P28659
      Related
      ENSMUSP00000005643.7, ENSMUST00000005643.13
      Conserved Domains (3) summary
      cd12631
      Location:42125
      RRM1_CELF1_2_Bruno; RNA recognition motif 1 in CUGBP Elav-like family member CELF-1, CELF-2, Drosophila melanogaster Bruno protein and similar proteins
      cd12634
      Location:134214
      RRM2_CELF1_2; RNA recognition motif 2 in CUGBP Elav-like family member CELF-1, CELF-2 and similar proteins
      cd12638
      Location:421512
      RRM3_CELF1_2; RNA recognition motif 3 in CUGBP Elav-like family member CELF-1, CELF-2 and similar proteins
    4. NM_198683.2NP_941955.1  CUGBP Elav-like family member 1 isoform 2

      See identical proteins and their annotated locations for NP_941955.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an exon in the 5' region, which results in a downstream AUG start codon, compared to variant 1. The resulting isoform (2) is shorter at the N-terminus, compared to isoform 1.
      Source sequence(s)
      AK143698, AL672241, BU056861, BU923429, CF171545, CX210403
      Consensus CDS
      CCDS16421.1
      UniProtKB/Swiss-Prot
      P28659
      Related
      ENSMUSP00000107078.3, ENSMUST00000111451.9
      Conserved Domains (3) summary
      cd12631
      Location:1598
      RRM1_CELF1_2_Bruno; RNA recognition motif 1 in CUGBP Elav-like family member CELF-1, CELF-2, Drosophila melanogaster Bruno protein and similar proteins
      cd12634
      Location:107187
      RRM2_CELF1_2; RNA recognition motif 2 in CUGBP Elav-like family member CELF-1, CELF-2 and similar proteins
      cd12638
      Location:394485
      RRM3_CELF1_2; RNA recognition motif 3 in CUGBP Elav-like family member CELF-1, CELF-2 and similar proteins

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000068.7 Reference GRCm38.p4 C57BL/6J

      Range
      90940387..91019497
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006498668.1XP_006498731.1  CUGBP Elav-like family member 1 isoform X1

      See identical proteins and their annotated locations for XP_006498731.1

      Conserved Domains (3) summary
      cd12631
      Location:42125
      RRM1_CELF1_2_Bruno; RNA recognition motif 1 in CUGBP Elav-like family member CELF-1, CELF-2, Drosophila melanogaster Bruno protein and similar proteins
      cd12634
      Location:134214
      RRM2_CELF1_2; RNA recognition motif 2 in CUGBP Elav-like family member CELF-1, CELF-2 and similar proteins
      cd12638
      Location:422513
      RRM3_CELF1_2; RNA recognition motif 3 in CUGBP Elav-like family member CELF-1, CELF-2 and similar proteins
    2. XM_006498669.1XP_006498732.1  CUGBP Elav-like family member 1 isoform X5

      See identical proteins and their annotated locations for XP_006498732.1

      UniProtKB/Swiss-Prot
      P28659
      Related
      ENSMUSP00000107082.2, ENSMUST00000111455.8
      Conserved Domains (3) summary
      cd12631
      Location:42125
      RRM1_CELF1_2_Bruno; RNA recognition motif 1 in CUGBP Elav-like family member CELF-1, CELF-2, Drosophila melanogaster Bruno protein and similar proteins
      cd12634
      Location:134214
      RRM2_CELF1_2; RNA recognition motif 2 in CUGBP Elav-like family member CELF-1, CELF-2 and similar proteins
      cd12638
      Location:421512
      RRM3_CELF1_2; RNA recognition motif 3 in CUGBP Elav-like family member CELF-1, CELF-2 and similar proteins
    3. XM_006498664.1XP_006498727.1  CUGBP Elav-like family member 1 isoform X4

      See identical proteins and their annotated locations for XP_006498727.1

      UniProtKB/Swiss-Prot
      P28659
      UniProtKB/TrEMBL
      A0A0R4J0T5
      Related
      ENSMUSP00000064323.6, ENSMUST00000068726.12
      Conserved Domains (3) summary
      cd12631
      Location:1598
      RRM1_CELF1_2_Bruno; RNA recognition motif 1 in CUGBP Elav-like family member CELF-1, CELF-2, Drosophila melanogaster Bruno protein and similar proteins
      cd12634
      Location:107187
      RRM2_CELF1_2; RNA recognition motif 2 in CUGBP Elav-like family member CELF-1, CELF-2 and similar proteins
      cd12638
      Location:395486
      RRM3_CELF1_2; RNA recognition motif 3 in CUGBP Elav-like family member CELF-1, CELF-2 and similar proteins
    4. XM_017315295.1XP_017170784.1  CUGBP Elav-like family member 1 isoform X1

      Conserved Domains (3) summary
      cd12631
      Location:42125
      RRM1_CELF1_2_Bruno; RNA recognition motif 1 in CUGBP Elav-like family member CELF-1, CELF-2, Drosophila melanogaster Bruno protein and similar proteins
      cd12634
      Location:134214
      RRM2_CELF1_2; RNA recognition motif 2 in CUGBP Elav-like family member CELF-1, CELF-2 and similar proteins
      cd12638
      Location:422513
      RRM3_CELF1_2; RNA recognition motif 3 in CUGBP Elav-like family member CELF-1, CELF-2 and similar proteins
    5. XM_006498661.1XP_006498724.1  CUGBP Elav-like family member 1 isoform X1

      See identical proteins and their annotated locations for XP_006498724.1

      Conserved Domains (3) summary
      cd12631
      Location:42125
      RRM1_CELF1_2_Bruno; RNA recognition motif 1 in CUGBP Elav-like family member CELF-1, CELF-2, Drosophila melanogaster Bruno protein and similar proteins
      cd12634
      Location:134214
      RRM2_CELF1_2; RNA recognition motif 2 in CUGBP Elav-like family member CELF-1, CELF-2 and similar proteins
      cd12638
      Location:422513
      RRM3_CELF1_2; RNA recognition motif 3 in CUGBP Elav-like family member CELF-1, CELF-2 and similar proteins
    6. XM_006498667.1XP_006498730.1  CUGBP Elav-like family member 1 isoform X6

      Conserved Domains (4) summary
      cd12631
      Location:42125
      RRM1_CELF1_2_Bruno; RNA recognition motif 1 in CUGBP Elav-like family member CELF-1, CELF-2, Drosophila melanogaster Bruno protein and similar proteins
      cd12634
      Location:134214
      RRM2_CELF1_2; RNA recognition motif 2 in CUGBP Elav-like family member CELF-1, CELF-2 and similar proteins
      cd12638
      Location:362451
      RRM3_CELF1_2; RNA recognition motif 3 in CUGBP Elav-like family member CELF-1, CELF-2 and similar proteins
      TIGR01661
      Location:45447
      ELAV_HUD_SF; ELAV/HuD family splicing factor
    7. XM_017315297.1XP_017170786.1  CUGBP Elav-like family member 1 isoform X7

    8. XM_006498662.1XP_006498725.1  CUGBP Elav-like family member 1 isoform X2

      See identical proteins and their annotated locations for XP_006498725.1

      Conserved Domains (3) summary
      cd12631
      Location:42125
      RRM1_CELF1_2_Bruno; RNA recognition motif 1 in CUGBP Elav-like family member CELF-1, CELF-2, Drosophila melanogaster Bruno protein and similar proteins
      cd12634
      Location:134214
      RRM2_CELF1_2; RNA recognition motif 2 in CUGBP Elav-like family member CELF-1, CELF-2 and similar proteins
      cd12638
      Location:418509
      RRM3_CELF1_2; RNA recognition motif 3 in CUGBP Elav-like family member CELF-1, CELF-2 and similar proteins
    9. XM_006498663.1XP_006498726.1  CUGBP Elav-like family member 1 isoform X3

      See identical proteins and their annotated locations for XP_006498726.1

      Conserved Domains (3) summary
      cd12631
      Location:42125
      RRM1_CELF1_2_Bruno; RNA recognition motif 1 in CUGBP Elav-like family member CELF-1, CELF-2, Drosophila melanogaster Bruno protein and similar proteins
      cd12634
      Location:134214
      RRM2_CELF1_2; RNA recognition motif 2 in CUGBP Elav-like family member CELF-1, CELF-2 and similar proteins
      cd12638
      Location:417508
      RRM3_CELF1_2; RNA recognition motif 3 in CUGBP Elav-like family member CELF-1, CELF-2 and similar proteins
    10. XM_006498665.3XP_006498728.1  CUGBP Elav-like family member 1 isoform X4

      See identical proteins and their annotated locations for XP_006498728.1

      UniProtKB/Swiss-Prot
      P28659
      UniProtKB/TrEMBL
      A0A0R4J0T5
      Conserved Domains (3) summary
      cd12631
      Location:1598
      RRM1_CELF1_2_Bruno; RNA recognition motif 1 in CUGBP Elav-like family member CELF-1, CELF-2, Drosophila melanogaster Bruno protein and similar proteins
      cd12634
      Location:107187
      RRM2_CELF1_2; RNA recognition motif 2 in CUGBP Elav-like family member CELF-1, CELF-2 and similar proteins
      cd12638
      Location:395486
      RRM3_CELF1_2; RNA recognition motif 3 in CUGBP Elav-like family member CELF-1, CELF-2 and similar proteins
    Support Center