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    Ctbp2 C-terminal binding protein 2 [ Mus musculus (house mouse) ]

    Gene ID: 13017, updated on 5-Mar-2019

    Summary

    Official Symbol
    Ctbp2provided by MGI
    Official Full Name
    C-terminal binding protein 2provided by MGI
    Primary source
    MGI:MGI:1201686
    See related
    Ensembl:ENSMUSG00000030970
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ribeye; Gtrgeo6; AA407280; D7Ertd45e
    Expression
    Ubiquitous expression in whole brain E14.5 (RPKM 16.7), CNS E14 (RPKM 16.5) and 27 other tissues See more
    Orthologs

    Genomic context

    See Ctbp2 in Genome Data Viewer
    Location:
    7 F3; 7 76.32 cM
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 7 NC_000073.6 (132987011..133123749, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (140178694..140315166, complement)

    Chromosome 7 - NC_000073.6Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1500002F19 gene Neighboring gene predicted gene, 46003 Neighboring gene zinc finger, RAN-binding domain containing 1 Neighboring gene RIKEN cDNA 4932437C15 gene Neighboring gene RIKEN cDNA 4930483O08 gene Neighboring gene predicted gene, 35364 Neighboring gene predicted gene, 35567

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    • Chronic myeloid leukemia, organism-specific biosystem (from KEGG)
      Chronic myeloid leukemia, organism-specific biosystemChronic myeloid leukemia (CML) is a clonal myeloproliferative disorder of a pluripotent stem cell. The natural history of CML has a triphasic clinical course comprising of an initial chronic phase (C...
    • Chronic myeloid leukemia, conserved biosystem (from KEGG)
      Chronic myeloid leukemia, conserved biosystemChronic myeloid leukemia (CML) is a clonal myeloproliferative disorder of a pluripotent stem cell. The natural history of CML has a triphasic clinical course comprising of an initial chronic phase (C...
    • Notch Signaling Pathway, organism-specific biosystem (from WikiPathways)
      Notch Signaling Pathway, organism-specific biosystemThe Notch signaling pathway is an evolutionarily conserved, intercellular signaling mechanism essential for proper embryonic development in all metazoan organisms in the Animal kingdom. The Notch pro...
    • Notch signaling pathway, organism-specific biosystem (from KEGG)
      Notch signaling pathway, organism-specific biosystemThe Notch signaling pathway is an evolutionarily conserved, intercellular signaling mechanism essential for proper embryonic development in all metazoan organisms in the Animal kingdom. The Notch pro...
    • Notch signaling pathway, conserved biosystem (from KEGG)
      Notch signaling pathway, conserved biosystemThe Notch signaling pathway is an evolutionarily conserved, intercellular signaling mechanism essential for proper embryonic development in all metazoan organisms in the Animal kingdom. The Notch pro...
    • Pathways in cancer, organism-specific biosystem (from KEGG)
      Pathways in cancer, organism-specific biosystem
      Pathways in cancer
    • PluriNetWork, organism-specific biosystem (from WikiPathways)
      PluriNetWork, organism-specific biosystemThe aim of the PluriNetWork is to give an overview of specific mechanisms associated with pluripotency in mouse. Each node represents a gene and its corresponding protein product. As stated, we inten...
    • Wnt Signaling Pathway NetPath, organism-specific biosystem (from WikiPathways)
      Wnt Signaling Pathway NetPath, organism-specific biosystemWnt family of proteins are a large family of cysteine-rich secreted glycoproteins that regulate cell-cell interactions. They bind to members of the Frizzled family of 7 transmembrane receptors. Bindi...
    • Wnt Signaling Pathway and Pluripotency, organism-specific biosystem (from WikiPathways)
      Wnt Signaling Pathway and Pluripotency, organism-specific biosystemThis pathway was adapted from several resources and is designed to provide a theoretical frame-work for examining Wnt signaling and interacting components in the context of embryonic stem-cell pluri...
    • Wnt signaling pathway, organism-specific biosystem (from KEGG)
      Wnt signaling pathway, organism-specific biosystemWnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, i...
    • Wnt signaling pathway, conserved biosystem (from KEGG)
      Wnt signaling pathway, conserved biosystemWnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, i...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    NAD binding IEA
    Inferred from Electronic Annotation
    more info
     
    chromatin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
     
    oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    retinoic acid receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    structural constituent of presynaptic active zone IDA
    Inferred from Direct Assay
    more info
    PubMed 
    structural constituent of presynaptic active zone IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    transcription coactivator activity IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    transcription corepressor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    transcription corepressor activity IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    GABA-ergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell junction IEA
    Inferred from Electronic Annotation
    more info
     
    glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    photoreceptor ribbon synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    photoreceptor ribbon synapse IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    presynaptic active zone cytoplasmic component IDA
    Inferred from Direct Assay
    more info
    PubMed 
    presynaptic cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ribbon synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    transcriptional repressor complex IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    C-terminal-binding protein 2
    Names
    gene trap ROSA b-geo 6

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001170744.1NP_001164215.1  C-terminal-binding protein 2 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC119806
      Consensus CDS
      CCDS52417.1
      UniProtKB/Swiss-Prot
      P56546
      Related
      ENSMUSP00000130294.1, ENSMUST00000169570.7
      Conserved Domains (2) summary
      COG0111
      Location:593903
      SerA; Phosphoglycerate dehydrogenase or related dehydrogenase [Coenzyme transport and metabolism, General function prediction only]
      cd05299
      Location:577895
      CtBP_dh; C-terminal binding protein (CtBP), D-isomer-specific 2-hydroxyacid dehydrogenases related repressor
    2. NM_001347623.1NP_001334552.1  C-terminal-binding protein 2 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) represents use of an alternate promoter and 5' splice pattern, compared to variant 1. The resulting isoform (3) has a shorter and distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AC119806
      UniProtKB/TrEMBL
      Q91YZ2
    3. NM_009980.4NP_034110.1  C-terminal-binding protein 2 isoform 2

      See identical proteins and their annotated locations for NP_034110.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) represents use of an alternate promoter and 5' splice pattern, compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AC119806, AC138624, AK147871, BI730932
      Consensus CDS
      CCDS21930.1
      UniProtKB/Swiss-Prot
      P56546
      UniProtKB/TrEMBL
      Q3UGL5
      Related
      ENSMUSP00000033269.8, ENSMUST00000033269.14
      Conserved Domains (1) summary
      cd05299
      Location:34352
      CtBP_dh; C-terminal binding protein (CtBP), D-isomer-specific 2-hydroxyacid dehydrogenases related repressor

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000073.6 Reference GRCm38.p4 C57BL/6J

      Range
      132987011..133123749 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006507315.3XP_006507378.1  C-terminal-binding protein 2 isoform X3

      See identical proteins and their annotated locations for XP_006507378.1

      UniProtKB/TrEMBL
      Q91YZ2
      Related
      ENSMUSP00000127448.1, ENSMUST00000166439.7
      Conserved Domains (2) summary
      COG0111
      Location:25335
      SerA; Phosphoglycerate dehydrogenase or related dehydrogenase [Coenzyme transport and metabolism, General function prediction only]
      cd05299
      Location:9327
      CtBP_dh; C-terminal binding protein (CtBP), D-isomer-specific 2-hydroxyacid dehydrogenases related repressor
    2. XM_006507309.3XP_006507372.1  C-terminal-binding protein 2 isoform X1

      See identical proteins and their annotated locations for XP_006507372.1

      UniProtKB/Swiss-Prot
      P56546
      UniProtKB/TrEMBL
      Q3UGL5
      Conserved Domains (1) summary
      cd05299
      Location:34352
      CtBP_dh; C-terminal binding protein (CtBP), D-isomer-specific 2-hydroxyacid dehydrogenases related repressor
    3. XM_006507310.3XP_006507373.1  C-terminal-binding protein 2 isoform X1

      See identical proteins and their annotated locations for XP_006507373.1

      UniProtKB/Swiss-Prot
      P56546
      UniProtKB/TrEMBL
      Q3UGL5
      Conserved Domains (1) summary
      cd05299
      Location:34352
      CtBP_dh; C-terminal binding protein (CtBP), D-isomer-specific 2-hydroxyacid dehydrogenases related repressor
    4. XM_006507312.3XP_006507375.1  C-terminal-binding protein 2 isoform X1

      See identical proteins and their annotated locations for XP_006507375.1

      UniProtKB/Swiss-Prot
      P56546
      UniProtKB/TrEMBL
      Q3UGL5
      Conserved Domains (1) summary
      cd05299
      Location:34352
      CtBP_dh; C-terminal binding protein (CtBP), D-isomer-specific 2-hydroxyacid dehydrogenases related repressor
    5. XM_006507314.3XP_006507377.1  C-terminal-binding protein 2 isoform X2

      Conserved Domains (2) summary
      COG0111
      Location:37347
      SerA; Phosphoglycerate dehydrogenase or related dehydrogenase [Coenzyme transport and metabolism, General function prediction only]
      cd05299
      Location:21339
      CtBP_dh; C-terminal binding protein (CtBP), D-isomer-specific 2-hydroxyacid dehydrogenases related repressor
    6. XM_006507308.3XP_006507371.1  C-terminal-binding protein 2 isoform X1

      See identical proteins and their annotated locations for XP_006507371.1

      UniProtKB/Swiss-Prot
      P56546
      UniProtKB/TrEMBL
      Q3UGL5
      Conserved Domains (1) summary
      cd05299
      Location:34352
      CtBP_dh; C-terminal binding protein (CtBP), D-isomer-specific 2-hydroxyacid dehydrogenases related repressor
    7. XM_006507311.3XP_006507374.1  C-terminal-binding protein 2 isoform X1

      See identical proteins and their annotated locations for XP_006507374.1

      UniProtKB/Swiss-Prot
      P56546
      UniProtKB/TrEMBL
      Q3UGL5
      Conserved Domains (1) summary
      cd05299
      Location:34352
      CtBP_dh; C-terminal binding protein (CtBP), D-isomer-specific 2-hydroxyacid dehydrogenases related repressor
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