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    Ctbp2 C-terminal binding protein 2 [ Mus musculus (house mouse) ]

    Gene ID: 13017, updated on 10-Oct-2024

    Summary

    Official Symbol
    Ctbp2provided by MGI
    Official Full Name
    C-terminal binding protein 2provided by MGI
    Primary source
    MGI:MGI:1201686
    See related
    Ensembl:ENSMUSG00000030970 AllianceGenome:MGI:1201686
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ribeye; Gtrgeo6; D7Ertd45e
    Summary
    Enables several functions, including retinoic acid receptor binding activity; transcription coactivator activity; and transcription corepressor activity. A structural constituent of presynaptic active zone. Involved in negative regulation of transcription, DNA-templated; synaptic vesicle docking; and white fat cell differentiation. Acts upstream of or within several processes, including cellular response to leukemia inhibitory factor; positive regulation of chromatin binding activity; and positive regulation of retinoic acid receptor signaling pathway. Located in several cellular components, including GABA-ergic synapse; glutamatergic synapse; and photoreceptor ribbon synapse. Part of transcription repressor complex. Is active in presynaptic active zone cytoplasmic component and presynaptic cytosol. Is expressed in several structures, including alimentary system; limb; lung; nervous system; and retina layer. Orthologous to human CTBP2 (C-terminal binding protein 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in whole brain E14.5 (RPKM 16.7), CNS E14 (RPKM 16.5) and 27 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Ctbp2 in Genome Data Viewer
    Location:
    7 F3; 7 76.32 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (132588727..132726048, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (132986998..133124009, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1500002F19 gene Neighboring gene STARR-positive B cell enhancer ABC_E3759 Neighboring gene predicted gene 45502 Neighboring gene zinc finger, RAN-binding domain containing 1 Neighboring gene RIKEN cDNA 4932437C15 gene Neighboring gene STARR-seq mESC enhancer starr_20308 Neighboring gene STARR-seq mESC enhancer starr_20317 Neighboring gene STARR-seq mESC enhancer starr_20324 Neighboring gene STARR-seq mESC enhancer starr_20325 Neighboring gene RIKEN cDNA 4930483O08 gene Neighboring gene predicted gene, 35364 Neighboring gene predicted gene, 35567

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA-binding transcription factor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables NAD binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables chromatin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables nuclear retinoic acid receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables structural constituent of presynaptic active zone IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables structural constituent of presynaptic active zone IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables transcription coactivator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables transcription coactivator activity IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    enables transcription coregulator binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables transcription coregulator binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables transcription corepressor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables transcription corepressor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables transcription corepressor activity IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables transcription corepressor binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within cellular response to leukemia inhibitory factor IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in maintenance of presynaptic active zone structure IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of DNA-templated transcription IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of chromatin binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of retinoic acid receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of retinoic acid receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in synaptic vesicle docking IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in synaptic vesicle docking IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in white fat cell differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in GABA-ergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in glutamatergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in photoreceptor ribbon synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in photoreceptor ribbon synapse IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    is_active_in presynaptic active zone cytoplasmic component IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in presynaptic cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in ribbon synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of transcription repressor complex IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    C-terminal-binding protein 2
    Names
    gene trap ROSA b-geo 6

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001170744.2NP_001164215.1  C-terminal-binding protein 2 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AC119806
      Consensus CDS
      CCDS52417.1
      UniProtKB/Swiss-Prot
      P56546
      Related
      ENSMUSP00000130294.2, ENSMUST00000169570.8
      Conserved Domains (2) summary
      COG0111
      Location:593903
      SerA; Phosphoglycerate dehydrogenase or related dehydrogenase [Coenzyme transport and metabolism, General function prediction only]
      cd05299
      Location:577895
      CtBP_dh; C-terminal binding protein (CtBP), D-isomer-specific 2-hydroxyacid dehydrogenases related repressor
    2. NM_001347623.2NP_001334552.1  C-terminal-binding protein 2 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) represents use of an alternate promoter and 5' splice pattern, compared to variant 1. The resulting isoform (3) has a shorter and distinct N-terminus, compared to isoform 1. Variants 3 and 13-19 all encode the same isoform (3).
      Source sequence(s)
      AC119806, AC138624
      Consensus CDS
      CCDS90344.1
      UniProtKB/TrEMBL
      Q3UIX8, Q91YZ2
      Conserved Domains (1) summary
      cd05299
      Location:9327
      CtBP_dh; C-terminal binding protein (CtBP), D-isomer-specific 2-hydroxyacid dehydrogenases related repressor
    3. NM_001412294.1NP_001399223.1  C-terminal-binding protein 2 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC119806
    4. NM_001412295.1NP_001399224.1  C-terminal-binding protein 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC119806, AC138624
      UniProtKB/Swiss-Prot
      O54855, O88462, P56546
      UniProtKB/TrEMBL
      Q3UGL5
    5. NM_001412296.1NP_001399225.1  C-terminal-binding protein 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC119806, AC138624
      UniProtKB/Swiss-Prot
      O54855, O88462, P56546
      UniProtKB/TrEMBL
      Q3UGL5
    6. NM_001412297.1NP_001399226.1  C-terminal-binding protein 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC119806, AC138624
      UniProtKB/Swiss-Prot
      O54855, O88462, P56546
      UniProtKB/TrEMBL
      Q3UGL5
    7. NM_001412298.1NP_001399227.1  C-terminal-binding protein 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC119806, AC138624
      UniProtKB/Swiss-Prot
      O54855, O88462, P56546
      UniProtKB/TrEMBL
      Q3UGL5
    8. NM_001412299.1NP_001399228.1  C-terminal-binding protein 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC119806, AC138624
      UniProtKB/Swiss-Prot
      O54855, O88462, P56546
      UniProtKB/TrEMBL
      Q3UGL5
    9. NM_001412300.1NP_001399229.1  C-terminal-binding protein 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC119806, AC138624
      UniProtKB/Swiss-Prot
      O54855, O88462, P56546
      UniProtKB/TrEMBL
      Q3UGL5
    10. NM_001412301.1NP_001399230.1  C-terminal-binding protein 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC119806, AC138624
      UniProtKB/Swiss-Prot
      O54855, O88462, P56546
      UniProtKB/TrEMBL
      Q3UGL5
    11. NM_001412302.1NP_001399231.1  C-terminal-binding protein 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC119806, AC138624
      UniProtKB/Swiss-Prot
      O54855, O88462, P56546
      UniProtKB/TrEMBL
      Q3UGL5
    12. NM_001412303.1NP_001399232.1  C-terminal-binding protein 2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC119806, AC138624
      UniProtKB/TrEMBL
      Q91YZ2
    13. NM_001412304.1NP_001399233.1  C-terminal-binding protein 2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC119806, AC138624
      UniProtKB/TrEMBL
      Q91YZ2
    14. NM_001412305.1NP_001399234.1  C-terminal-binding protein 2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC119806, AC138624
      UniProtKB/TrEMBL
      Q91YZ2
    15. NM_001412306.1NP_001399235.1  C-terminal-binding protein 2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC119806, AC138624
      UniProtKB/TrEMBL
      Q91YZ2
    16. NM_001412307.1NP_001399236.1  C-terminal-binding protein 2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC119806, AC138624
      UniProtKB/TrEMBL
      Q91YZ2
      Related
      ENSMUSP00000127448.2, ENSMUST00000166439.8
    17. NM_001412308.1NP_001399237.1  C-terminal-binding protein 2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC119806, AC138624
      UniProtKB/TrEMBL
      Q91YZ2
    18. NM_001412309.1NP_001399238.1  C-terminal-binding protein 2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC119806, AC138624
      UniProtKB/TrEMBL
      Q91YZ2
    19. NM_009980.5NP_034110.1  C-terminal-binding protein 2 isoform 2

      See identical proteins and their annotated locations for NP_034110.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) represents use of an alternate promoter and 5' splice pattern, compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus, compared to isoform 1. Variants 2 and 5-12 all encode the same isoform (2).
      Source sequence(s)
      AC119806, AC138624
      Consensus CDS
      CCDS21930.1
      UniProtKB/Swiss-Prot
      O54855, O88462, P56546
      UniProtKB/TrEMBL
      Q3UGL5, Q3UIX8
      Related
      ENSMUSP00000033269.9, ENSMUST00000033269.15
      Conserved Domains (1) summary
      cd05299
      Location:34352
      CtBP_dh; C-terminal binding protein (CtBP), D-isomer-specific 2-hydroxyacid dehydrogenases related repressor

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      132588727..132726048 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036152630.1XP_036008523.1  C-terminal-binding protein 2 isoform X2

      UniProtKB/TrEMBL
      Q3UIX8, Q91YZ2
      Conserved Domains (1) summary
      cd05299
      Location:9327
      CtBP_dh; C-terminal binding protein (CtBP), D-isomer-specific 2-hydroxyacid dehydrogenases related repressor