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    Csnk2b casein kinase 2, beta polypeptide [ Mus musculus (house mouse) ]

    Gene ID: 13001, updated on 31-Jan-2019

    Summary

    Official Symbol
    Csnk2bprovided by MGI
    Official Full Name
    casein kinase 2, beta polypeptideprovided by MGI
    Primary source
    MGI:MGI:88548
    See related
    Ensembl:ENSMUSG00000024387
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CK II beta
    Summary
    This gene encodes the beta subunit of the casein kinase 2 enzyme, which is a heterotetramer comprised of alpha and/or alpha-prime catalytic subunits and two regulatory beta subunits. Casein kinase 2 is involved in the regulation of several cellular processes including gene expression, protein synthesis and cell proliferation. Knockout of this gene in mice leads to embryonic lethality. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2015]
    Expression
    Broad expression in testis adult (RPKM 540.1), duodenum adult (RPKM 75.4) and 23 other tissues See more
    Orthologs

    Genomic context

    See Csnk2b in Genome Data Viewer
    Location:
    17 B1; 17 18.59 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 17 NC_000083.6 (35116195..35122053, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 17 NC_000083.5 (35253140..35258392, complement)

    Chromosome 17 - NC_000083.6Genomic Context describing neighboring genes Neighboring gene lymphocyte antigen 6 complex, locus G5C Neighboring gene lymphocyte antigen 6 complex, locus G5B Neighboring gene G patch domain and ankyrin repeats 1 Neighboring gene predicted gene 20522 Neighboring gene DNA segment, Chr 17, human D6S53E Neighboring gene apolipoprotein M

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Potential readthrough

    Included gene: Ly6g5b

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    chromatin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    chromatin binding ISO
    Inferred from Sequence Orthology
    more info
     
    identical protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein domain specific binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein kinase regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    contributes_to protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    ribonucleoprotein complex binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    ribonucleoprotein complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    signaling receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    signaling receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    transcription factor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    adiponectin-activated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    adiponectin-activated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    endothelial tube morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    endothelial tube morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    liver regeneration IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    negative regulation of blood vessel endothelial cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    negative regulation of blood vessel endothelial cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    peptidyl-threonine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of activin receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of activin receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of pathway-restricted SMAD protein phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of pathway-restricted SMAD protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    postsynaptic modulation of chemical synaptic transmission ISO
    Inferred from Sequence Orthology
    more info
     
    response to testosterone IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    colocalizes_with PcG protein complex ISO
    Inferred from Sequence Orthology
    more info
     
    Schaffer collateral - CA1 synapse ISO
    Inferred from Sequence Orthology
    more info
     
    cell projection ISO
    Inferred from Sequence Orthology
    more info
     
    chromatin ISO
    Inferred from Sequence Orthology
    more info
     
    cilium ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear matrix ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    protein kinase CK2 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein kinase CK2 complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    casein kinase II subunit beta
    Names
    phosvitin
    NP_001290374.1
    NP_001290375.1
    NP_001290405.1
    NP_034105.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001303445.1NP_001290374.1  casein kinase II subunit beta isoform 2

      See identical proteins and their annotated locations for NP_001290374.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) contains an alternate 5' terminal exon and uses a downstream start codon compared to variant 1. It encodes isoform 2 which has a shorter N-terminus compared to isoform 1. Variants 2 and 3 encode the same isoform (2).
      Source sequence(s)
      CR974444
      Consensus CDS
      CCDS28684.1
      UniProtKB/Swiss-Prot
      P67871
      Related
      ENSMUSP00000134218.1, ENSMUST00000173114.7
      Conserved Domains (1) summary
      smart01085
      Location:8191
      CK_II_beta; Casein kinase II regulatory subunit
    2. NM_001303446.1NP_001290375.1  casein kinase II subunit beta isoform 1

      See identical proteins and their annotated locations for NP_001290375.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes isoform 1.
      Source sequence(s)
      CR974444
      Related
      ENSMUSP00000134523.2, ENSMUST00000172765.8
      Conserved Domains (1) summary
      smart01085
      Location:29212
      CK_II_beta; Casein kinase II regulatory subunit
    3. NM_001303476.1NP_001290405.1  casein kinase II subunit beta isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) contains multiple differences in the 5' UTR and coding region compared to variant 1, including initiation of translation at a downstream start codon. It encodes isoform 3, which is longer than isoform 1 and has a shorter N-terminus and a distinct C-terminus.
      Source sequence(s)
      CR974444
      Consensus CDS
      CCDS79541.1
      UniProtKB/TrEMBL
      G3UZX4
      Related
      ENSMUSP00000134673.1, ENSMUST00000174024.7
      Conserved Domains (1) summary
      smart01085
      Location:8129
      CK_II_beta; Casein kinase II regulatory subunit
    4. NM_009975.3NP_034105.1  casein kinase II subunit beta isoform 2

      See identical proteins and their annotated locations for NP_034105.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) contains an alternate 5' terminal exon and uses a downstream start codon compared to variant 1. It encodes isoform 2 which has a shorter N-terminus compared to isoform 1. Variants 2 and 3 encode the same isoform (2).
      Source sequence(s)
      CR974444
      Consensus CDS
      CCDS28684.1
      UniProtKB/Swiss-Prot
      P67871
      Related
      ENSMUSP00000025246.6, ENSMUST00000025246.12
      Conserved Domains (1) summary
      smart01085
      Location:8191
      CK_II_beta; Casein kinase II regulatory subunit

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000083.6 Reference GRCm38.p4 C57BL/6J

      Range
      35116195..35122053 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCm38.p4 129X1/SvJ

    Genomic

    1. NT_039662.3 Reference GRCm38.p4 129X1/SvJ

      Range
      1365893..1371751 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCm38.p4 NOD/MrkTac

    Genomic

    1. NT_187027.1 Reference GRCm38.p4 NOD/MrkTac

      Range
      1434377..1440235 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCm38.p4 NOD/ShiLtJ

    Genomic

    1. NT_187004.1 Reference GRCm38.p4 NOD/ShiLtJ

      Range
      1434614..1440472 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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