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    Csnk2a2 casein kinase 2, alpha prime polypeptide [ Mus musculus (house mouse) ]

    Gene ID: 13000, updated on 2-Oct-2018

    Summary

    Official Symbol
    Csnk2a2provided by MGI
    Official Full Name
    casein kinase 2, alpha prime polypeptideprovided by MGI
    Primary source
    MGI:MGI:88547
    See related
    Ensembl:ENSMUSG00000046707 Vega:OTTMUSG00000061759
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CK2; C77789; 1110035J23Rik
    Expression
    Ubiquitous expression in testis adult (RPKM 14.5), CNS E11.5 (RPKM 7.2) and 27 other tissues See more
    Orthologs

    Genomic context

    See Csnk2a2 in Genome Data Viewer
    Location:
    8 C5; 8 47.12 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 8 NC_000074.6 (95446096..95489069, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 8 NC_000074.5 (97969996..98012720, complement)

    Chromosome 8 - NC_000074.6Genomic Context describing neighboring genes Neighboring gene matrix metallopeptidase 15 Neighboring gene cilia and flagella associated protein 20 Neighboring gene RIKEN cDNA 4933406B17 gene Neighboring gene coiled-coil domain containing 113

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein N-terminus binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein serine/threonine kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    peptidyl-serine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of cell cycle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of chromosome separation ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    colocalizes_with PcG protein complex ISO
    Inferred from Sequence Orthology
    more info
     
    acrosomal vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    chromatin ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    protein kinase CK2 complex TAS
    Traceable Author Statement
    more info
    PubMed 

    General protein information

    Preferred Names
    casein kinase II subunit alpha'
    Names
    CK II alpha'
    casein kinase II, alpha 2, polypeptide
    NP_034104.1
    XP_006530704.1
    XP_006530705.1
    XP_006530706.1
    XP_017168045.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_009974.3NP_034104.1  casein kinase II subunit alpha'

      See identical proteins and their annotated locations for NP_034104.1

      Status: VALIDATED

      Source sequence(s)
      AC165414, AK002927, AK030035, BM963966, CB056745
      Consensus CDS
      CCDS22562.1
      UniProtKB/Swiss-Prot
      O54833
      UniProtKB/TrEMBL
      Q545V8, Q8CDH5
      Related
      ENSMUSP00000055919.7, OTTMUSP00000078161, ENSMUST00000056919.8, OTTMUST00000150714
      Conserved Domains (1) summary
      cd14132
      Location:22326
      STKc_CK2_alpha; Catalytic subunit (alpha) of the Serine/Threonine Kinase, Casein Kinase 2

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000074.6 Reference GRCm38.p4 C57BL/6J

      Range
      95446096..95489069 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017312556.1XP_017168045.1  casein kinase II subunit alpha' isoform X1

    2. XM_006530641.3XP_006530704.1  casein kinase II subunit alpha' isoform X2

      Conserved Domains (2) summary
      cd14132
      Location:22275
      STKc_CK2_alpha; Catalytic subunit (alpha) of the Serine/Threonine Kinase, Casein Kinase 2
      pfam00069
      Location:40274
      Pkinase; Protein kinase domain
    3. XM_006530643.3XP_006530706.1  casein kinase II subunit alpha' isoform X3

      See identical proteins and their annotated locations for XP_006530706.1

      Conserved Domains (1) summary
      cd14132
      Location:1189
      STKc_CK2_alpha; Catalytic subunit (alpha) of the Serine/Threonine Kinase, Casein Kinase 2
    4. XM_006530642.1XP_006530705.1  casein kinase II subunit alpha' isoform X3

      See identical proteins and their annotated locations for XP_006530705.1

      Related
      ENSMUSP00000148660.1, OTTMUSP00000078164, ENSMUST00000212616.1, OTTMUST00000150717
      Conserved Domains (1) summary
      cd14132
      Location:1189
      STKc_CK2_alpha; Catalytic subunit (alpha) of the Serine/Threonine Kinase, Casein Kinase 2
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