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    Csnk2a1 casein kinase 2, alpha 1 polypeptide [ Mus musculus (house mouse) ]

    Gene ID: 12995, updated on 6-Sep-2021

    Summary

    Official Symbol
    Csnk2a1provided by MGI
    Official Full Name
    casein kinase 2, alpha 1 polypeptideprovided by MGI
    Primary source
    MGI:MGI:88543
    See related
    Ensembl:ENSMUSG00000074698
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CK2; Csnk2a; Csnk2a1-rs4
    Summary
    Casein kinase II is a serine/threonine protein kinase that phosphorylates acidic proteins such as casein. It is involved in various cellular processes, including cell cycle control, apoptosis, and circadian rhythms. The kinase exists as a tetramer and is composed of an alpha, an alpha-prime, and two beta subunits. The alpha subunits contain the catalytic activity while the beta subunits undergo autophosphorylation. The protein encoded by this gene represents the alpha subunit. [provided by RefSeq, Feb 2014]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 27.4), whole brain E14.5 (RPKM 26.5) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Csnk2a1 in Genome Data Viewer
    Location:
    2; 2 G3
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (152067851..152123772)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (152226535..152281856)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (152052576..152107588)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene transcription factor 15 Neighboring gene ribosomal protein S15A, pseudogene 7 Neighboring gene TBC1 domain family, member 20 Neighboring gene RanBP-type and C3HC4-type zinc finger containing 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Targeted (2)  1 citation
    • Endonuclease-mediated (1) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC102141

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables beta-catenin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein N-terminus binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein phosphatase regulator activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables ribonucleoprotein complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of cysteine-type endopeptidase activity involved in apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in peptidyl-serine phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in peptidyl-serine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in peptidyl-threonine phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in peptidyl-threonine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cell growth ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within protein autophosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in regulation of chromosome separation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of protein localization to plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within rhythmic process IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    part_of NuRD complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of PcG protein complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of Sin3 complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in chromatin ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    part_of protein kinase CK2 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of protein kinase CK2 complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of protein kinase CK2 complex TAS
    Traceable Author Statement
    more info
    PubMed 

    General protein information

    Preferred Names
    casein kinase II subunit alpha
    Names
    CK II alpha
    casein kinase II, alpha 1 polypeptide
    casein kinase II, alpha 1 related sequence 4
    NP_031814.2
    XP_006498720.1
    XP_011237574.1
    XP_030102934.1
    XP_030102935.1
    XP_030102936.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_007788.3NP_031814.2  casein kinase II subunit alpha

      See identical proteins and their annotated locations for NP_031814.2

      Status: VALIDATED

      Source sequence(s)
      AK042898, AK146032, BF018216, BY015187, CA322616
      Consensus CDS
      CCDS16879.1
      UniProtKB/Swiss-Prot
      Q60737
      Related
      ENSMUSP00000096829.4, ENSMUST00000099224.10
      Conserved Domains (1) summary
      cd14132
      Location:20325
      STKc_CK2_alpha; Catalytic subunit (alpha) of the Serine/Threonine Kinase, Casein Kinase 2

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      152067851..152123772
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030247076.2XP_030102936.1  casein kinase II subunit alpha isoform X1

      Conserved Domains (1) summary
      cd14132
      Location:20325
      STKc_CK2_alpha; Catalytic subunit (alpha) of the Serine/Threonine Kinase, Casein Kinase 2
    2. XM_006498657.5XP_006498720.1  casein kinase II subunit alpha isoform X1

      See identical proteins and their annotated locations for XP_006498720.1

      UniProtKB/Swiss-Prot
      Q60737
      Conserved Domains (1) summary
      cd14132
      Location:20325
      STKc_CK2_alpha; Catalytic subunit (alpha) of the Serine/Threonine Kinase, Casein Kinase 2
    3. XM_030247075.2XP_030102935.1  casein kinase II subunit alpha isoform X1

      Conserved Domains (1) summary
      cd14132
      Location:20325
      STKc_CK2_alpha; Catalytic subunit (alpha) of the Serine/Threonine Kinase, Casein Kinase 2
    4. XM_030247074.2XP_030102934.1  casein kinase II subunit alpha isoform X1

      Conserved Domains (1) summary
      cd14132
      Location:20325
      STKc_CK2_alpha; Catalytic subunit (alpha) of the Serine/Threonine Kinase, Casein Kinase 2
    5. XM_011239272.4XP_011237574.1  casein kinase II subunit alpha isoform X1

      See identical proteins and their annotated locations for XP_011237574.1

      UniProtKB/Swiss-Prot
      Q60737
      Conserved Domains (1) summary
      cd14132
      Location:20325
      STKc_CK2_alpha; Catalytic subunit (alpha) of the Serine/Threonine Kinase, Casein Kinase 2
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