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    Csk c-src tyrosine kinase [ Mus musculus (house mouse) ]

    Gene ID: 12988, updated on 17-Oct-2018

    Summary

    Official Symbol
    Cskprovided by MGI
    Official Full Name
    c-src tyrosine kinaseprovided by MGI
    Primary source
    MGI:MGI:88537
    See related
    Ensembl:ENSMUSG00000032312 Vega:OTTMUSG00000063203
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    p50CSK; AW212630
    Expression
    Ubiquitous expression in spleen adult (RPKM 65.3), thymus adult (RPKM 53.3) and 27 other tissues See more
    Orthologs

    Genomic context

    See Csk in Genome Data Viewer
    Location:
    9 B; 9 31.18 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 9 NC_000075.6 (57626646..57653631, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 9 NC_000075.5 (57474453..57492987, complement)

    Chromosome 9 - NC_000075.6Genomic Context describing neighboring genes Neighboring gene complexin 3 Neighboring gene predicted gene, 32392 Neighboring gene lectin, mannose-binding 1 like Neighboring gene cytochrome P450, family 1, subfamily a, polypeptide 2 Neighboring gene cytochrome P450, family 1, subfamily a, polypeptide 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATP binding TAS
    Traceable Author Statement
    more info
    PubMed 
    identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    non-membrane spanning protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    proline-rich region binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein kinase A catalytic subunit binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein phosphatase binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein tyrosine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein tyrosine kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    protein tyrosine kinase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    transferase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    adaptive immune response IEA
    Inferred from Electronic Annotation
    more info
     
    adherens junction organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cellular response to peptide hormone stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    immune system process IEA
    Inferred from Electronic Annotation
    more info
     
    intracellular signal transduction TAS
    Traceable Author Statement
    more info
    PubMed 
    negative regulation of ERK1 and ERK2 cascade ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of Golgi to plasma membrane protein transport ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of bone resorption ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cell proliferation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    negative regulation of cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of interleukin-6 production ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of low-density lipoprotein particle clearance ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of phagocytosis ISO
    Inferred from Sequence Orthology
    more info
     
    phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of MAP kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein autophosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    protein phosphorylation TAS
    Traceable Author Statement
    more info
    PubMed 
    regulation of Fc receptor mediated stimulatory signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    regulation of Fc receptor mediated stimulatory signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of T cell activation TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    cell-cell junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    membrane raft ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane TAS
    Traceable Author Statement
    more info
    PubMed 

    General protein information

    Preferred Names
    tyrosine-protein kinase CSK
    Names
    C-Src kinase
    protein-tyrosine kinase MPK-2
    NP_001291690.1
    NP_031809.2
    XP_006510864.1
    XP_006510865.1
    XP_011240961.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001304761.1NP_001291690.1  tyrosine-protein kinase CSK

      See identical proteins and their annotated locations for NP_001291690.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      BC052006, BC095962
      Consensus CDS
      CCDS23228.1
      UniProtKB/Swiss-Prot
      P41241
      Related
      ENSMUSP00000150590.1, OTTMUSP00000079602, ENSMUST00000215396.1, OTTMUST00000153895
      Conserved Domains (3) summary
      cd05082
      Location:188443
      PTKc_Csk; Catalytic domain of the Protein Tyrosine Kinase, C-terminal Src kinase
      cd09937
      Location:78175
      SH2_csk_like; Src homology 2 (SH2) domain found in Carboxyl-Terminal Src Kinase (Csk)
      cd11769
      Location:1167
      SH3_CSK; Src Homology 3 domain of C-terminal Src kinase
    2. NM_007783.3NP_031809.2  tyrosine-protein kinase CSK

      See identical proteins and their annotated locations for NP_031809.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the shorter transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK136876, BC052006
      Consensus CDS
      CCDS23228.1
      UniProtKB/Swiss-Prot
      P41241
      Related
      ENSMUSP00000034863.6, OTTMUSP00000079600, ENSMUST00000034863.7, OTTMUST00000153893
      Conserved Domains (3) summary
      cd05082
      Location:188443
      PTKc_Csk; Catalytic domain of the Protein Tyrosine Kinase, C-terminal Src kinase
      cd09937
      Location:78175
      SH2_csk_like; Src homology 2 (SH2) domain found in Carboxyl-Terminal Src Kinase (Csk)
      cd11769
      Location:1167
      SH3_CSK; Src Homology 3 domain of C-terminal Src kinase

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000075.6 Reference GRCm38.p4 C57BL/6J

      Range
      57626646..57653631 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006510801.3XP_006510864.1  tyrosine-protein kinase CSK isoform X1

      See identical proteins and their annotated locations for XP_006510864.1

      UniProtKB/Swiss-Prot
      P41241
      Conserved Domains (3) summary
      cd05082
      Location:188443
      PTKc_Csk; Catalytic domain of the Protein Tyrosine Kinase, C-terminal Src kinase
      cd09937
      Location:78175
      SH2_csk_like; Src homology 2 (SH2) domain found in Carboxyl-Terminal Src Kinase (Csk)
      cd11769
      Location:1167
      SH3_CSK; Src Homology 3 domain of C-terminal Src kinase
    2. XM_006510802.3XP_006510865.1  tyrosine-protein kinase CSK isoform X1

      See identical proteins and their annotated locations for XP_006510865.1

      UniProtKB/Swiss-Prot
      P41241
      Related
      ENSMUSP00000150984.1, OTTMUSP00000079601, ENSMUST00000217314.1, OTTMUST00000153894
      Conserved Domains (3) summary
      cd05082
      Location:188443
      PTKc_Csk; Catalytic domain of the Protein Tyrosine Kinase, C-terminal Src kinase
      cd09937
      Location:78175
      SH2_csk_like; Src homology 2 (SH2) domain found in Carboxyl-Terminal Src Kinase (Csk)
      cd11769
      Location:1167
      SH3_CSK; Src Homology 3 domain of C-terminal Src kinase
    3. XM_011242659.2XP_011240961.1  tyrosine-protein kinase CSK isoform X2

      Conserved Domains (2) summary
      cd09937
      Location:78154
      SH2_csk_like; Src homology 2 (SH2) domain found in Carboxyl-Terminal Src Kinase (Csk)
      cd11769
      Location:1167
      SH3_CSK; Src Homology 3 domain of C-terminal Src kinase
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