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    Crkl v-crk avian sarcoma virus CT10 oncogene homolog-like [ Mus musculus (house mouse) ]

    Gene ID: 12929, updated on 31-Jan-2019

    Summary

    Official Symbol
    Crklprovided by MGI
    Official Full Name
    v-crk avian sarcoma virus CT10 oncogene homolog-likeprovided by MGI
    Primary source
    MGI:MGI:104686
    See related
    Ensembl:ENSMUSG00000006134
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Crkol; snoop; AA589403; AI325100; 1110025F07Rik
    Summary
    This gene is part of a family of adapter proteins that mediate formation of signal transduction complexes in response to extracellular stimuli, such as growth and differentiation factors. Protein-protein interactions occur through the SH2 domain, which binds phosphorylated tyrosine residues, and the SH3 domain, which binds proline-rich peptide motifs. These interactions promote recruitment and activation of effector proteins to regulate cell migration, adhesion, and proliferation. In certain mouse genetic backgrounds this protein is essential for embryonic development. It is important for neural crest cell differentiation and survival and is proposed to play an important role in transducing the oncogenic signal of Bcr/Abl. Deletion of this gene in mouse mimics the phenotype of DiGeorge/velocardiofacial syndrome in human. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Mar 2013]
    Expression
    Ubiquitous expression in thymus adult (RPKM 14.0), whole brain E14.5 (RPKM 13.0) and 28 other tissues See more
    Orthologs

    Genomic context

    See Crkl in Genome Data Viewer
    Location:
    16; 16 A3
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 16 NC_000082.6 (17451985..17487440)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 16 NC_000082.5 (17452080..17486348)

    Chromosome 16 - NC_000082.6Genomic Context describing neighboring genes Neighboring gene phosphatidylinositol 4-kinase alpha Neighboring gene poly(A) binding protein, cytoplasmic 1 pseudogene Neighboring gene synaptosomal-associated protein 29 Neighboring gene apoptosis-inducing factor, mitochondrion-associated 3 Neighboring gene leucine-zipper-like transcriptional regulator, 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    RNA polymerase II activating transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    phosphotyrosine residue binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    B cell apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    T cell receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acetylcholine receptor signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    activation of GTPase activity IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    activation of MAPK activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    animal organ morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    anterior/posterior pattern specification IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    blood vessel development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    cell chemotaxis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    cellular response to drug IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular response to interleukin-7 IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular response to transforming growth factor beta stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    cerebellar neuron development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    cerebral cortex development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    cranial skeletal system development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    dendrite development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    endothelin receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    establishment of cell polarity IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    fibroblast growth factor receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    heart development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    helper T cell diapedesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    hippocampus development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    lipid metabolic process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    male gonad development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    neuron migration IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    neuron migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    outflow tract morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    parathyroid gland development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    pattern specification process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    pharynx development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of ERK1 and ERK2 cascade IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of ERK1 and ERK2 cascade ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of glial cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of substrate adhesion-dependent cell spreading ISO
    Inferred from Sequence Orthology
    more info
     
    reelin-mediated signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    reelin-mediated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of T cell migration IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    regulation of cell adhesion mediated by integrin IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    regulation of cell growth IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of dendrite development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of leukocyte migration IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    regulation of skeletal muscle acetylcholine-gated channel clustering IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    response to fibroblast growth factor IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    retinoic acid receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    single fertilization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    spermatogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    synapse assembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    synapse assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    thymus development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    urogenital system development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    extrinsic component of postsynaptic membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    neuromuscular junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    neuromuscular junction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    protein-containing complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    crk-like protein
    Names
    v-crk sarcoma virus CT10 oncogene homolog-like

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001277231.1NP_001264160.1  crk-like protein isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an exon in the coding region, which results in a frameshift and an early stop codon compared to variant 1. The encoded isoform (2) is shorter and has a distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AK048641, AK052315, AW541802, BF453354, BF464821, BY471344, CA328740
      UniProtKB/Swiss-Prot
      P47941
      Related
      ENSMUSP00000156063.1, ENSMUST00000231629.1
      Conserved Domains (1) summary
      cd09926
      Location:6104
      SH2_CRK_like; Src homology 2 domain found in cancer-related signaling adaptor protein CRK
    2. NM_007764.5NP_031790.2  crk-like protein isoform 1

      See identical proteins and their annotated locations for NP_031790.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK048641, AK052315, AW541802, BF453354, BF464821, BY471344
      Consensus CDS
      CCDS28002.1
      UniProtKB/Swiss-Prot
      P47941
      UniProtKB/TrEMBL
      A2RS58
      Related
      ENSMUSP00000006293.3, ENSMUST00000006293.4
      Conserved Domains (3) summary
      cd09926
      Location:6106
      SH2_CRK_like; Src homology 2 domain found in cancer-related signaling adaptor protein CRK
      cd11758
      Location:126180
      SH3_CRK_N; N-terminal Src Homology 3 domain of Ct10 Regulator of Kinase adaptor proteins
      cd11759
      Location:237293
      SH3_CRK_C; C-terminal Src Homology 3 domain of Ct10 Regulator of Kinase adaptor proteins

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000082.6 Reference GRCm38.p4 C57BL/6J

      Range
      17451985..17487440
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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