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    Crk v-crk avian sarcoma virus CT10 oncogene homolog [ Mus musculus (house mouse) ]

    Gene ID: 12928, updated on 15-Apr-2019

    Summary

    Official Symbol
    Crkprovided by MGI
    Official Full Name
    v-crk avian sarcoma virus CT10 oncogene homologprovided by MGI
    Primary source
    MGI:MGI:88508
    See related
    Ensembl:ENSMUSG00000017776
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    p38; Crk3; Crko; Crk-I; c-Crk; Crk-II; CrkIII; Crk-III
    Summary
    This gene is part of a family of adapter proteins that mediate formation of signal transduction complexes in response to extracellular stimuli, such as growth and differentiation factors. Protein-protein interactions occur through the SH2 domain, which binds phosphorylated tyrosine residues, and the SH3 domain, which binds proline-rich peptide motifs. These interactions promote recruitment and activation of effector proteins to regulate cell migration, adhesion, and proliferation. In mouse this protein is essential for embryonic development. Alternatively spliced transcripts encoding different isoforms with distinct biological activity have been described. [provided by RefSeq, Mar 2013]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 18.5), bladder adult (RPKM 18.1) and 28 other tissues See more
    Orthologs

    Genomic context

    See Crk in Genome Data Viewer
    Location:
    11 B5; 11 45.92 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 11 NC_000077.6 (75679248..75708428)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (75492812..75519594)

    Chromosome 11 - NC_000077.6Genomic Context describing neighboring genes Neighboring gene inositol polyphosphate 5-phosphatase K Neighboring gene myosin IC Neighboring gene tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide Neighboring gene double C2, beta Neighboring gene predicted gene 12339

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    SH2 domain binding ISO
    Inferred from Sequence Orthology
    more info
     
    SH3 domain binding ISO
    Inferred from Sequence Orthology
    more info
     
    SH3/SH2 adaptor activity IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    SH3/SH2 adaptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    cytoskeletal protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    ephrin receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    ephrin receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    insulin-like growth factor receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    phosphotyrosine residue binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein binding, bridging ISO
    Inferred from Sequence Orthology
    more info
     
    protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein phosphorylated amino acid binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein phosphorylated amino acid binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein self-association ISO
    Inferred from Sequence Orthology
    more info
     
    protein tyrosine kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    scaffold protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    activation of GTPase activity IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    cell chemotaxis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    cellular response to endothelin ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to insulin-like growth factor stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to nerve growth factor stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to nitric oxide ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to transforming growth factor beta stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    cerebellar neuron development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    cerebral cortex development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    dendrite development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    ephrin receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    establishment of cell polarity IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    helper T cell diapedesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    hippocampus development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    lipid metabolic process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    negative regulation of cell motility ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of natural killer cell mediated cytotoxicity ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of wound healing ISO
    Inferred from Sequence Orthology
    more info
     
    neuron migration IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of cell growth ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of smooth muscle cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of substrate adhesion-dependent cell spreading ISO
    Inferred from Sequence Orthology
    more info
     
    reelin-mediated signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    regulation of GTPase activity ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of Rac protein signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of T cell migration IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    regulation of actin cytoskeleton organization IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    regulation of actin cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of cell adhesion mediated by integrin IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    regulation of cell shape ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of dendrite development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    regulation of leukocyte migration IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    regulation of protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    response to cholecystokinin ISO
    Inferred from Sequence Orthology
    more info
     
    response to hepatocyte growth factor ISO
    Inferred from Sequence Orthology
    more info
     
    response to hydrogen peroxide ISO
    Inferred from Sequence Orthology
    more info
     
    response to peptide ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    actin cytoskeleton IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    membrane raft ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    adapter molecule crk
    Names
    CT-10 related kinase 3
    avian sarcoma virus CT10 (v-crk) oncogene homolog
    proto-oncogene c-crk
    v-crk sarcoma virus CT10 oncogene-like protein

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001277219.1NP_001264148.1  adapter molecule crk isoform 1

      See identical proteins and their annotated locations for NP_001264148.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the shorter isoform 1 (also known as CrkI). Isoform 1 (CrkI) contains the SH2 domain and the N-terminal SH3 domain, both of which are proposed to be crucial for development.
      Source sequence(s)
      AK139089, AL591440
      Consensus CDS
      CCDS70241.1
      UniProtKB/TrEMBL
      Q8JZR2
      Related
      ENSMUSP00000104063.1, ENSMUST00000108425.7
      Conserved Domains (2) summary
      cd09926
      Location:5122
      SH2_CRK_like; Src homology 2 domain found in cancer-related signaling adaptor protein CRK
      cd11758
      Location:135189
      SH3_CRK_N; N-terminal Src Homology 3 domain of Ct10 Regulator of Kinase adaptor proteins
    2. NM_001277221.1NP_001264150.1  adapter molecule crk isoform 3

      See identical proteins and their annotated locations for NP_001264150.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks an alternate, in-frame exon in the coding region compared to variant 1. The encoded isoform (3) is shorter than isoform 1 (CrkI). Isoform 3 does not have a complete SH2 domain and lacks an SH3 domain, both of which are found in isoform 1.
      Source sequence(s)
      AL591440
      Consensus CDS
      CCDS70242.1
      UniProtKB/TrEMBL
      Q3TQV3
      Related
      ENSMUSP00000104064.1, ENSMUST00000108426.7
      Conserved Domains (1) summary
      cl15255
      Location:563
      SH2; Src homology 2 (SH2) domain
    3. NM_133656.5NP_598417.2  adapter molecule crk isoform 2

      See identical proteins and their annotated locations for NP_598417.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) includes an alternate segment, compared to variant 1, resulting in a longer protein (isoform 2, also known as CrkII) that has a distinct C-terminus and an additional SH3 domain, compared to isoform 1 (CrkI). Isoform 2 (CrkII) is proposed to have a negative regulatory role.
      Source sequence(s)
      AK028488, AL591440
      Consensus CDS
      CCDS25055.1
      UniProtKB/Swiss-Prot
      Q64010
      UniProtKB/TrEMBL
      Q5ND51
      Related
      ENSMUSP00000017920.7, ENSMUST00000017920.13
      Conserved Domains (3) summary
      cd09926
      Location:5122
      SH2_CRK_like; Src homology 2 domain found in cancer-related signaling adaptor protein CRK
      cd11758
      Location:135189
      SH3_CRK_N; N-terminal Src Homology 3 domain of Ct10 Regulator of Kinase adaptor proteins
      cd11759
      Location:237293
      SH3_CRK_C; C-terminal Src Homology 3 domain of Ct10 Regulator of Kinase adaptor proteins

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000077.6 Reference GRCm38.p4 C57BL/6J

      Range
      75679248..75708428
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006532125.2XP_006532188.1  adapter molecule crk isoform X2

      See identical proteins and their annotated locations for XP_006532188.1

      UniProtKB/TrEMBL
      Q5ND50
      Related
      ENSMUSP00000090803.3, ENSMUST00000093115.3
      Conserved Domains (2) summary
      cd09926
      Location:5122
      SH2_CRK_like; Src homology 2 domain found in cancer-related signaling adaptor protein CRK
      cd11758
      Location:135189
      SH3_CRK_N; N-terminal Src Homology 3 domain of Ct10 Regulator of Kinase adaptor proteins
    2. XM_006532124.2XP_006532187.1  adapter molecule crk isoform X1

      See identical proteins and their annotated locations for XP_006532187.1

      Related
      ENSMUSP00000116527.1, ENSMUST00000147718.1
      Conserved Domains (3) summary
      cd09926
      Location:5122
      SH2_CRK_like; Src homology 2 domain found in cancer-related signaling adaptor protein CRK
      cd11758
      Location:135189
      SH3_CRK_N; N-terminal Src Homology 3 domain of Ct10 Regulator of Kinase adaptor proteins
      cl17036
      Location:237259
      SH3; Src Homology 3 domain superfamily
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