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    Crebbp CREB binding protein [ Mus musculus (house mouse) ]

    Gene ID: 12914, updated on 3-Aug-2021

    Summary

    Official Symbol
    Crebbpprovided by MGI
    Official Full Name
    CREB binding proteinprovided by MGI
    Primary source
    MGI:MGI:1098280
    See related
    Ensembl:ENSMUSG00000022521
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CB; CBP; KAT; KAT3A; AW558298; CBP/p300; p300/CBP
    Expression
    Ubiquitous expression in thymus adult (RPKM 18.7), spleen adult (RPKM 14.3) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Crebbp in Genome Data Viewer
    Location:
    16 A1; 16 2.4 cM
    Exon count:
    31
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (3899198..4031864, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (4081334..4213957, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 16 NC_000082.5 (4084048..4213404, complement)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene SLX4 structure-specific endonuclease subunit homolog (S. cerevisiae) Neighboring gene deoxyribonuclease I Neighboring gene TNF receptor-associated protein 1 Neighboring gene RIKEN cDNA 4930455F16 gene Neighboring gene ribosomal protein L7a pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables DNA-binding transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables MRF binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables RNA polymerase II-specific DNA-binding transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables RNA polymerase II-specific DNA-binding transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables SMAD binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables TFIIB-class transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables acetyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables acyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables cAMP response element binding protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables chromatin DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables chromatin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables chromatin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables damaged DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables disordered domain specific binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables histone acetyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables histone acetyltransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables histone acetyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables histone acetyltransferase activity TAS
    Traceable Author Statement
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables p53 binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables peptide-lysine-N-acetyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables peptide-lysine-N-acetyltransferase activity TAS
    Traceable Author Statement
    more info
     
    enables peroxisome proliferator activated receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein domain specific binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables transcription coactivator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables transcription coactivator activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables transcription coactivator activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables transcription coactivator activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables transcription coactivator binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables transcription coregulator activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables transcription corepressor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables zinc ion binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in N-terminal peptidyl-lysine acetylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in behavioral response to cocaine ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to UV ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within cellular response to hepatocyte growth factor stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cellular response to virus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in face morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within germ-line stem cell population maintenance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in histone acetylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in histone acetylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in histone glutamine methylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in long-term memory ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of interferon-beta production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of viral process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of CREB transcription factor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of DNA-binding transcription factor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in positive regulation of G1/S transition of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of NIK/NF-kappaB signaling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cell adhesion molecule production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of dendritic spine development ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of gene expression IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of transcription, DNA-templated IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of transcription, DNA-templated IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of transforming growth factor beta receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein acetylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein destabilization ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of transcription, DNA-templated IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of transcription, DNA-templated IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within rhythmic process IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in PML body ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    part_of RNA polymerase II transcription regulator complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in chromatin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in chromatin ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    part_of histone acetyltransferase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of histone acetyltransferase complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    part_of outer kinetochore IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of protein-containing complex IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of transcription regulator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of transcription regulator complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of transcription regulator complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    histone lysine acetyltransferase CREBBP
    Names
    protein-lysine acetyltransferase CREBBP
    NP_001020603.1
    XP_006521814.1
    XP_006521815.1
    XP_006521816.1
    XP_006521817.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001025432.1NP_001020603.1  histone lysine acetyltransferase CREBBP

      See identical proteins and their annotated locations for NP_001020603.1

      Status: VALIDATED

      Source sequence(s)
      BC010297, BC072594, BU705617, CAAA01026247
      Consensus CDS
      CCDS27915.1
      UniProtKB/TrEMBL
      F8VPR5, Q6GQV9
      Related
      ENSMUSP00000023165.7, ENSMUST00000023165.9
      Conserved Domains (10) summary
      cd05495
      Location:10881195
      Bromo_cbp_like; Bromodomain, cbp_like subfamily. Cbp (CREB binding protein or CREBBP) is an acetyltransferase acting on histone, which gives a specific tag for transcriptional activation and also acetylates non-histone proteins. CREBBP binds specifically to ...
      smart00551
      Location:17671845
      ZnF_TAZ; TAZ zinc finger, present in p300 and CBP
      COG5076
      Location:9421194
      COG5076; Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription]
      cd02337
      Location:17061746
      ZZ_CBP; Zinc finger, ZZ type. Zinc finger present in CBP/p300 and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. CREB-binding protein (CBP) is a large multidomain protein that ...
      cd15802
      Location:12071279
      RING_CBP-p300; atypical RING domain found in CREB-binding protein and p300 histone acetyltransferases
      cd15557
      Location:12811312
      PHD_CBP_p300; PHD finger found in CREB-binding protein (CBP) and histone acetyltransferase p300
      pfam02135
      Location:362429
      zf-TAZ; TAZ zinc finger
      pfam02172
      Location:586666
      KIX; KIX domain
      pfam08214
      Location:13431650
      HAT_KAT11; Histone acetylation protein
      pfam09030
      Location:20352112
      Creb_binding; Creb binding

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      3899198..4031864 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006521754.5XP_006521817.1  histone lysine acetyltransferase CREBBP isoform X4

      UniProtKB/TrEMBL
      A0A0U1RQB6
      Related
      ENSMUSP00000146330.2, ENSMUST00000205765.2
      Conserved Domains (12) summary
      cd05495
      Location:10501157
      Bromo_cbp_like; Bromodomain, cbp_like subfamily. Cbp (CREB binding protein or CREBBP) is an acetyltransferase acting on histone, which gives a specific tag for transcriptional activation and also acetylates non-histone proteins. CREBBP binds specifically to ...
      smart00551
      Location:17291807
      ZnF_TAZ; TAZ zinc finger, present in p300 and CBP
      PHA03247
      Location:649999
      PHA03247; large tegument protein UL36; Provisional
      COG5076
      Location:9041156
      COG5076; Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription]
      cd02337
      Location:16681708
      ZZ_CBP; Zinc finger, ZZ type. Zinc finger present in CBP/p300 and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. CREB-binding protein (CBP) is a large multidomain protein that ...
      cd15802
      Location:11691241
      RING_CBP-p300; atypical RING domain found in CREB-binding protein and p300 histone acetyltransferases
      cd15557
      Location:12431274
      PHD_CBP_p300; PHD finger found in CREB-binding protein (CBP) and histone acetyltransferase p300
      pfam09606
      Location:19232374
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      pfam02135
      Location:362404
      zf-TAZ; TAZ zinc finger
      pfam02172
      Location:548628
      KIX; KIX domain
      pfam08214
      Location:13051516
      HAT_KAT11; Histone acetylation protein
      pfam09030
      Location:19972077
      Creb_binding; Creb binding
    2. XM_006521753.5XP_006521816.1  histone lysine acetyltransferase CREBBP isoform X3

      Conserved Domains (12) summary
      cd05495
      Location:10501157
      Bromo_cbp_like; Bromodomain, cbp_like subfamily. Cbp (CREB binding protein or CREBBP) is an acetyltransferase acting on histone, which gives a specific tag for transcriptional activation and also acetylates non-histone proteins. CREBBP binds specifically to ...
      smart00551
      Location:17391817
      ZnF_TAZ; TAZ zinc finger, present in p300 and CBP
      PHA03247
      Location:649999
      PHA03247; large tegument protein UL36; Provisional
      COG5076
      Location:9041156
      COG5076; Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription]
      cd02337
      Location:16781718
      ZZ_CBP; Zinc finger, ZZ type. Zinc finger present in CBP/p300 and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. CREB-binding protein (CBP) is a large multidomain protein that ...
      cd15802
      Location:11691251
      RING_CBP-p300; atypical RING domain found in CREB-binding protein and p300 histone acetyltransferases
      cd15557
      Location:12531284
      PHD_CBP_p300; PHD finger found in CREB-binding protein (CBP) and histone acetyltransferase p300
      pfam09606
      Location:19332384
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      pfam02135
      Location:362404
      zf-TAZ; TAZ zinc finger
      pfam02172
      Location:548628
      KIX; KIX domain
      pfam08214
      Location:13151526
      HAT_KAT11; Histone acetylation protein
      pfam09030
      Location:20072087
      Creb_binding; Creb binding
    3. XM_006521751.5XP_006521814.1  histone lysine acetyltransferase CREBBP isoform X1

      Conserved Domains (12) summary
      cd05495
      Location:10881195
      Bromo_cbp_like; Bromodomain, cbp_like subfamily. Cbp (CREB binding protein or CREBBP) is an acetyltransferase acting on histone, which gives a specific tag for transcriptional activation and also acetylates non-histone proteins. CREBBP binds specifically to ...
      smart00551
      Location:17771855
      ZnF_TAZ; TAZ zinc finger, present in p300 and CBP
      PHA03247
      Location:6871037
      PHA03247; large tegument protein UL36; Provisional
      COG5076
      Location:9421194
      COG5076; Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription]
      cd02337
      Location:17161756
      ZZ_CBP; Zinc finger, ZZ type. Zinc finger present in CBP/p300 and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. CREB-binding protein (CBP) is a large multidomain protein that ...
      cd15802
      Location:12071289
      RING_CBP-p300; atypical RING domain found in CREB-binding protein and p300 histone acetyltransferases
      cd15557
      Location:12911322
      PHD_CBP_p300; PHD finger found in CREB-binding protein (CBP) and histone acetyltransferase p300
      pfam09606
      Location:19712422
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      pfam02135
      Location:362429
      zf-TAZ; TAZ zinc finger
      pfam02172
      Location:586666
      KIX; KIX domain
      pfam08214
      Location:13531564
      HAT_KAT11; Histone acetylation protein
      pfam09030
      Location:20452125
      Creb_binding; Creb binding
    4. XM_006521752.4XP_006521815.1  histone lysine acetyltransferase CREBBP isoform X2

      Conserved Domains (12) summary
      cd05495
      Location:10831190
      Bromo_cbp_like; Bromodomain, cbp_like subfamily. Cbp (CREB binding protein or CREBBP) is an acetyltransferase acting on histone, which gives a specific tag for transcriptional activation and also acetylates non-histone proteins. CREBBP binds specifically to ...
      smart00551
      Location:17721850
      ZnF_TAZ; TAZ zinc finger, present in p300 and CBP
      PHA03247
      Location:6801032
      PHA03247; large tegument protein UL36; Provisional
      COG5076
      Location:9371189
      COG5076; Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription]
      cd02337
      Location:17111751
      ZZ_CBP; Zinc finger, ZZ type. Zinc finger present in CBP/p300 and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. CREB-binding protein (CBP) is a large multidomain protein that ...
      cd15802
      Location:12021284
      RING_CBP-p300; atypical RING domain found in CREB-binding protein and p300 histone acetyltransferases
      cd15557
      Location:12861317
      PHD_CBP_p300; PHD finger found in CREB-binding protein (CBP) and histone acetyltransferase p300
      pfam09606
      Location:19662417
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      pfam02135
      Location:362429
      zf-TAZ; TAZ zinc finger
      pfam02172
      Location:586666
      KIX; KIX domain
      pfam08214
      Location:13481559
      HAT_KAT11; Histone acetylation protein
      pfam09030
      Location:20402120
      Creb_binding; Creb binding
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