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    Cpeb1 cytoplasmic polyadenylation element binding protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 12877, updated on 31-Jan-2019

    Summary

    Official Symbol
    Cpeb1provided by MGI
    Official Full Name
    cytoplasmic polyadenylation element binding protein 1provided by MGI
    Primary source
    MGI:MGI:108442
    See related
    Ensembl:ENSMUSG00000025586
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Cpeb; mCPEB; Cpe-bp1; mCpeb-1; AU024112
    Expression
    Broad expression in cortex adult (RPKM 9.8), frontal lobe adult (RPKM 9.6) and 15 other tissues See more
    Orthologs

    Genomic context

    See Cpeb1 in Genome Data Viewer
    Location:
    7; 7 D3
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 7 NC_000073.6 (81347026..81456936, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (88492329..88599562, complement)

    Chromosome 7 - NC_000073.6Genomic Context describing neighboring genes Neighboring gene phosphodiesterase 8A Neighboring gene translocase of inner mitochondrial membrane 17a pseudogene Neighboring gene ribosomal protein S17 Neighboring gene small nuclear ribonucleoprotein 48 (U11/U12) pseudogene Neighboring gene ribosomal protein L7A, pseudogene 9 Neighboring gene adaptor-related protein complex 3, beta 2 subunit Neighboring gene cDNA sequence BC048679

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    • Dorso-ventral axis formation, organism-specific biosystem (from KEGG)
      Dorso-ventral axis formation, organism-specific biosystem
      Dorso-ventral axis formation
    • Dorso-ventral axis formation, conserved biosystem (from KEGG)
      Dorso-ventral axis formation, conserved biosystem
      Dorso-ventral axis formation
    • Oocyte meiosis, organism-specific biosystem (from KEGG)
      Oocyte meiosis, organism-specific biosystemDuring meiosis, a single round of DNA replication is followed by two rounds of chromosome segregation, called meiosis I and meiosis II. At meiosis I, homologous chromosomes recombine and then segrega...
    • Oocyte meiosis, conserved biosystem (from KEGG)
      Oocyte meiosis, conserved biosystemDuring meiosis, a single round of DNA replication is followed by two rounds of chromosome segregation, called meiosis I and meiosis II. At meiosis I, homologous chromosomes recombine and then segrega...
    • Progesterone-mediated oocyte maturation, organism-specific biosystem (from KEGG)
      Progesterone-mediated oocyte maturation, organism-specific biosystemXenopus oocytes are naturally arrested at G2 of meiosis I. Exposure to either insulin/IGF-1 or the steroid hormone progesterone breaks this arrest and induces resumption of the two meiotic division c...
    • Progesterone-mediated oocyte maturation, conserved biosystem (from KEGG)
      Progesterone-mediated oocyte maturation, conserved biosystemXenopus oocytes are naturally arrested at G2 of meiosis I. Exposure to either insulin/IGF-1 or the steroid hormone progesterone breaks this arrest and induces resumption of the two meiotic division c...
    • mRNA processing, organism-specific biosystem (from WikiPathways)
      mRNA processing, organism-specific biosystemAdapted from Reactome, see: [http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_1675.1 REACT 1675.1] This process describes the conversion of precursor messenger RNA into mature messenge...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC159179

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    RNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mRNA 3'-UTR AU-rich region binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mRNA 3'-UTR binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    mRNA 3'-UTR binding ISO
    Inferred from Sequence Orthology
    more info
     
    mRNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    ribosome binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    translation factor activity, RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    translation regulator activity IEA
    Inferred from Electronic Annotation
    more info
     
    translation repressor activity, mRNA regulatory element binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    translation repressor activity, mRNA regulatory element binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    cellular response to amino acid stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular response to hypoxia IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular response to hypoxia ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to insulin stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    mRNA processing IEA
    Inferred from Electronic Annotation
    more info
     
    mRNA transport ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cytoplasmic translation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    negative regulation of cytoplasmic translation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of cytoplasmic translation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of translation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of mRNA polyadenylation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of neuron projection development ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of nitric-oxide synthase biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of translation ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of neuronal synaptic plasticity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of translation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    synaptonemal complex assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    cell junction IEA
    Inferred from Electronic Annotation
    more info
     
    centrosome ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    growth cone ISO
    Inferred from Sequence Orthology
    more info
     
    meiotic spindle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    messenger ribonucleoprotein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    neuron projection IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
     
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    postsynaptic density ISO
    Inferred from Sequence Orthology
    more info
     
    postsynaptic membrane IEA
    Inferred from Electronic Annotation
    more info
     
    synapse IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    cytoplasmic polyadenylation element-binding protein 1
    Names
    CPE-binding protein 1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001252525.1NP_001239454.1  cytoplasmic polyadenylation element-binding protein 1 isoform 1

      See identical proteins and their annotated locations for NP_001239454.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and it encodes the longest protein (isoform 1).
      Source sequence(s)
      AK077799, BC125476, BY720025, CO803180
      Consensus CDS
      CCDS57557.1
      UniProtKB/Swiss-Prot
      P70166
      UniProtKB/TrEMBL
      Q059Z2
      Related
      ENSMUSP00000137079.1, ENSMUST00000178892.2
      Conserved Domains (4) summary
      cd12723
      Location:309416
      RRM1_CPEB1; RNA recognition motif 1 in cytoplasmic polyadenylation element-binding protein 1 (CPEB-1) and similar proteins
      cd12725
      Location:427512
      RRM2_CPEB1; RNA recognition motif 2 in cytoplasmic polyadenylation element-binding protein 1 (CPEB-1) and similar proteins
      pfam16366
      Location:504559
      CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain
      pfam16368
      Location:1307
      CEBP1_N; Cytoplasmic polyadenylation element-binding protein 1 N-terminus
    2. NM_001252526.1NP_001239455.1  cytoplasmic polyadenylation element-binding protein 1 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses a different splice in the coding region, compared to variant 1. The resulting protein (isoform 3) is shorter when it is compared to isoform 1.
      Source sequence(s)
      AK077799, BC125476, BC144948, BY720025, CO803180
      UniProtKB/Swiss-Prot
      P70166
      UniProtKB/TrEMBL
      Q059Z2
      Related
      ENSMUSP00000120139.1, ENSMUST00000130310.7
      Conserved Domains (4) summary
      cd12723
      Location:308410
      RRM1_CPEB1; RNA recognition motif 1 in cytoplasmic polyadenylation element-binding protein 1 (CPEB-1) and similar proteins
      cd12725
      Location:421506
      RRM2_CPEB1; RNA recognition motif 2 in cytoplasmic polyadenylation element-binding protein 1 (CPEB-1) and similar proteins
      pfam16366
      Location:498553
      CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain
      pfam16368
      Location:1306
      CEBP1_N; Cytoplasmic polyadenylation element-binding protein 1 N-terminus
    3. NM_001357107.1NP_001344036.1  cytoplasmic polyadenylation element-binding protein 1 isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) represents use of an alternate promoter and therefore differs in the 5' UTR and 5' coding region, compared to variant 1. These differences cause translation initiation at a downstream start codon and result in an isoform (4) with a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AC162897, CO803180
      Conserved Domains (4) summary
      cd12723
      Location:233335
      RRM1_CPEB1; RNA recognition motif 1 in cytoplasmic polyadenylation element-binding protein 1 (CPEB-1) and similar proteins
      cd12725
      Location:346431
      RRM2_CPEB1; RNA recognition motif 2 in cytoplasmic polyadenylation element-binding protein 1 (CPEB-1) and similar proteins
      pfam16366
      Location:423478
      CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain
      pfam16368
      Location:1231
      CEBP1_N; Cytoplasmic polyadenylation element-binding protein 1 N-terminus
    4. NM_007755.5NP_031781.1  cytoplasmic polyadenylation element-binding protein 1 isoform 2

      See identical proteins and their annotated locations for NP_031781.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses a different splice in the coding region, compared to variant 1. The resulting protein (isoform 2) is shorter when it is compared to isoform 1.
      Source sequence(s)
      AK077799, BC144948, BY720025, CO803180, Y08260
      Consensus CDS
      CCDS40007.1
      UniProtKB/Swiss-Prot
      P70166
      Related
      ENSMUSP00000095936.3, ENSMUST00000098331.9
      Conserved Domains (4) summary
      cd12723
      Location:308415
      RRM1_CPEB1; RNA recognition motif 1 in cytoplasmic polyadenylation element-binding protein 1 (CPEB-1) and similar proteins
      cd12725
      Location:426511
      RRM2_CPEB1; RNA recognition motif 2 in cytoplasmic polyadenylation element-binding protein 1 (CPEB-1) and similar proteins
      pfam16366
      Location:503558
      CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain
      pfam16368
      Location:1306
      CEBP1_N; Cytoplasmic polyadenylation element-binding protein 1 N-terminus

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000073.6 Reference GRCm38.p4 C57BL/6J

      Range
      81347026..81456936 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017321964.1XP_017177453.1  cytoplasmic polyadenylation element-binding protein 1 isoform X6

      Conserved Domains (4) summary
      cd12723
      Location:233340
      RRM1_CPEB1; RNA recognition motif 1 in cytoplasmic polyadenylation element-binding protein 1 (CPEB-1) and similar proteins
      cd12725
      Location:351436
      RRM2_CPEB1; RNA recognition motif 2 in cytoplasmic polyadenylation element-binding protein 1 (CPEB-1) and similar proteins
      pfam16366
      Location:428483
      CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain
      pfam16368
      Location:1231
      CEBP1_N; Cytoplasmic polyadenylation element-binding protein 1 N-terminus
    2. XM_017321965.1XP_017177454.1  cytoplasmic polyadenylation element-binding protein 1 isoform X7

    3. XM_011250788.2XP_011249090.1  cytoplasmic polyadenylation element-binding protein 1 isoform X5

      Conserved Domains (4) summary
      cd12723
      Location:347437
      RRM1_CPEB1; RNA recognition motif 1 in cytoplasmic polyadenylation element-binding protein 1 (CPEB-1) and similar proteins
      cd12725
      Location:448533
      RRM2_CPEB1; RNA recognition motif 2 in cytoplasmic polyadenylation element-binding protein 1 (CPEB-1) and similar proteins
      pfam16366
      Location:525580
      CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain
      pfam16368
      Location:48345
      CEBP1_N; Cytoplasmic polyadenylation element-binding protein 1 N-terminus
    4. XM_011250784.2XP_011249086.1  cytoplasmic polyadenylation element-binding protein 1 isoform X1

      Conserved Domains (4) summary
      cd12723
      Location:347454
      RRM1_CPEB1; RNA recognition motif 1 in cytoplasmic polyadenylation element-binding protein 1 (CPEB-1) and similar proteins
      cd12725
      Location:465550
      RRM2_CPEB1; RNA recognition motif 2 in cytoplasmic polyadenylation element-binding protein 1 (CPEB-1) and similar proteins
      pfam16366
      Location:542597
      CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain
      pfam16368
      Location:48345
      CEBP1_N; Cytoplasmic polyadenylation element-binding protein 1 N-terminus
    5. XM_011250785.2XP_011249087.1  cytoplasmic polyadenylation element-binding protein 1 isoform X2

      Conserved Domains (4) summary
      cd12723
      Location:346453
      RRM1_CPEB1; RNA recognition motif 1 in cytoplasmic polyadenylation element-binding protein 1 (CPEB-1) and similar proteins
      cd12725
      Location:464549
      RRM2_CPEB1; RNA recognition motif 2 in cytoplasmic polyadenylation element-binding protein 1 (CPEB-1) and similar proteins
      pfam16366
      Location:541596
      CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain
      pfam16368
      Location:48344
      CEBP1_N; Cytoplasmic polyadenylation element-binding protein 1 N-terminus
    6. XM_011250790.2XP_011249092.1  cytoplasmic polyadenylation element-binding protein 1 isoform X6

      See identical proteins and their annotated locations for XP_011249092.1

      Conserved Domains (4) summary
      cd12723
      Location:233340
      RRM1_CPEB1; RNA recognition motif 1 in cytoplasmic polyadenylation element-binding protein 1 (CPEB-1) and similar proteins
      cd12725
      Location:351436
      RRM2_CPEB1; RNA recognition motif 2 in cytoplasmic polyadenylation element-binding protein 1 (CPEB-1) and similar proteins
      pfam16366
      Location:428483
      CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain
      pfam16368
      Location:1231
      CEBP1_N; Cytoplasmic polyadenylation element-binding protein 1 N-terminus
    7. XM_011250792.1XP_011249094.1  cytoplasmic polyadenylation element-binding protein 1 isoform X8

      Conserved Domains (4) summary
      cd12723
      Location:179286
      RRM1_CPEB1; RNA recognition motif 1 in cytoplasmic polyadenylation element-binding protein 1 (CPEB-1) and similar proteins
      cd12725
      Location:297382
      RRM2_CPEB1; RNA recognition motif 2 in cytoplasmic polyadenylation element-binding protein 1 (CPEB-1) and similar proteins
      pfam16366
      Location:374429
      CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain
      pfam16368
      Location:1177
      CEBP1_N; Cytoplasmic polyadenylation element-binding protein 1 N-terminus
    8. XM_011250786.2XP_011249088.1  cytoplasmic polyadenylation element-binding protein 1 isoform X3

      Conserved Domains (4) summary
      cd12723
      Location:347449
      RRM1_CPEB1; RNA recognition motif 1 in cytoplasmic polyadenylation element-binding protein 1 (CPEB-1) and similar proteins
      cd12725
      Location:460545
      RRM2_CPEB1; RNA recognition motif 2 in cytoplasmic polyadenylation element-binding protein 1 (CPEB-1) and similar proteins
      pfam16366
      Location:537592
      CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain
      pfam16368
      Location:48345
      CEBP1_N; Cytoplasmic polyadenylation element-binding protein 1 N-terminus
    9. XM_011250787.2XP_011249089.1  cytoplasmic polyadenylation element-binding protein 1 isoform X4

      Conserved Domains (4) summary
      cd12723
      Location:346448
      RRM1_CPEB1; RNA recognition motif 1 in cytoplasmic polyadenylation element-binding protein 1 (CPEB-1) and similar proteins
      cd12725
      Location:459544
      RRM2_CPEB1; RNA recognition motif 2 in cytoplasmic polyadenylation element-binding protein 1 (CPEB-1) and similar proteins
      pfam16366
      Location:536591
      CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain
      pfam16368
      Location:48344
      CEBP1_N; Cytoplasmic polyadenylation element-binding protein 1 N-terminus
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