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    Cox8a cytochrome c oxidase subunit 8A [ Mus musculus (house mouse) ]

    Gene ID: 12868, updated on 31-Jan-2019

    Summary

    Official Symbol
    Cox8aprovided by MGI
    Official Full Name
    cytochrome c oxidase subunit 8Aprovided by MGI
    Primary source
    MGI:MGI:105959
    See related
    Ensembl:ENSMUSG00000035885
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    COX8L
    Expression
    Ubiquitous expression in duodenum adult (RPKM 1660.4), colon adult (RPKM 1505.4) and 27 other tissues See more
    Orthologs

    Genomic context

    See Cox8a in Genome Data Viewer
    Location:
    19; 19 A
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 19 NC_000085.6 (7215158..7217616, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 19 NC_000085.5 (7289648..7292106, complement)

    Chromosome 19 - NC_000085.6Genomic Context describing neighboring genes Neighboring gene MACRO domain containing 1 Neighboring gene fibronectin leucine rich transmembrane protein 1 Neighboring gene predicted gene, 38621 Neighboring gene OTU domain, ubiquitin aldehyde binding 1 Neighboring gene N(alpha)-acetyltransferase 40, NatD catalytic subunit Neighboring gene REST corepressor 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Pathways from BioSystems

    • Alzheimer's disease, organism-specific biosystem (from KEGG)
      Alzheimer's disease, organism-specific biosystemAlzheimer's disease (AD) is a chronic disorder that slowly destroys neurons and causes serious cognitive disability. AD is associated with senile plaques and neurofibrillary tangles (NFTs). Amyloid-b...
    • Alzheimer's disease, conserved biosystem (from KEGG)
      Alzheimer's disease, conserved biosystemAlzheimer's disease (AD) is a chronic disorder that slowly destroys neurons and causes serious cognitive disability. AD is associated with senile plaques and neurofibrillary tangles (NFTs). Amyloid-b...
    • Arachidonate Epoxygenase Epoxide Hydrolase, organism-specific biosystem (from WikiPathways)
      Arachidonate Epoxygenase Epoxide Hydrolase, organism-specific biosystemThe cytochrome P450-dependent formation of polyunsaturated fatty acid epoxides is an important biochemical pathway creating mediators of inflammation and blood pressure regulation. Once formed these...
    • Cardiac muscle contraction, organism-specific biosystem (from KEGG)
      Cardiac muscle contraction, organism-specific biosystemContraction of the heart is a complex process initiated by the electrical excitation of cardiac myocytes (excitation-contraction coupling, ECC). In cardiac myocytes, Ca2+ influx induced by activation...
    • Cardiac muscle contraction, conserved biosystem (from KEGG)
      Cardiac muscle contraction, conserved biosystemContraction of the heart is a complex process initiated by the electrical excitation of cardiac myocytes (excitation-contraction coupling, ECC). In cardiac myocytes, Ca2+ influx induced by activation...
    • Cytochrome c oxidase, organism-specific biosystem (from KEGG)
      Cytochrome c oxidase, organism-specific biosystemStructural complex; Energy metabolism; ATP synthesis
    • Cytochrome c oxidase, conserved biosystem (from KEGG)
      Cytochrome c oxidase, conserved biosystemStructural complex; Energy metabolism; ATP synthesis
    • Electron Transport Chain, organism-specific biosystem (from WikiPathways)
      Electron Transport Chain, organism-specific biosystemAn electron transport chain(ETC) couples a chemical reaction between an electron donor (such as NADH) and an electron acceptor (such as O2) to the transfer of H+ ions across a membrane, through a set...
    • Huntington's disease, organism-specific biosystem (from KEGG)
      Huntington's disease, organism-specific biosystemHuntington disease (HD) is an autosomal-dominant neurodegenerative disorder that primarily affects medium spiny striatal neurons (MSN). The symptoms are choreiform, involuntary movements, personality...
    • Huntington's disease, conserved biosystem (from KEGG)
      Huntington's disease, conserved biosystemHuntington disease (HD) is an autosomal-dominant neurodegenerative disorder that primarily affects medium spiny striatal neurons (MSN). The symptoms are choreiform, involuntary movements, personality...
    • Metabolic pathways, organism-specific biosystem (from KEGG)
      Metabolic pathways, organism-specific biosystem
      Metabolic pathways
    • Non-alcoholic fatty liver disease (NAFLD), organism-specific biosystem (from KEGG)
      Non-alcoholic fatty liver disease (NAFLD), organism-specific biosystemNon-alcoholic fatty liver disease (NAFLD) represents a spectrum ranging from simple steatosis to more severe steatohepatitis with hepatic inflammation and fibrosis, known as nonalcoholic steatohepati...
    • Non-alcoholic fatty liver disease (NAFLD), conserved biosystem (from KEGG)
      Non-alcoholic fatty liver disease (NAFLD), conserved biosystemNon-alcoholic fatty liver disease (NAFLD) represents a spectrum ranging from simple steatosis to more severe steatohepatitis with hepatic inflammation and fibrosis, known as nonalcoholic steatohepati...
    • Oxidative phosphorylation, organism-specific biosystem (from KEGG)
      Oxidative phosphorylation, organism-specific biosystem
      Oxidative phosphorylation
    • Oxidative phosphorylation, conserved biosystem (from KEGG)
      Oxidative phosphorylation, conserved biosystem
      Oxidative phosphorylation
    • Parkinson's disease, organism-specific biosystem (from KEGG)
      Parkinson's disease, organism-specific biosystemParkinson's disease (PD) is a progressive neurodegenerative movement disorder that results primarily from the death of dopaminergic (DA) neurons in the substantia nigra pars compacta (SNc). Mutations...

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    cytochrome-c oxidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
     
    mitochondrion HDA PubMed 
    mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    respiratory chain complex IV IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    cytochrome c oxidase subunit 8A, mitochondrial
    Names
    COX VIII-L
    cytochrome c oxidase polypeptide VIII-liver
    cytochrome c oxidase subunit 8-2
    cytochrome c oxidase subunit VIIIa
    NP_031776.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_007750.2NP_031776.1  cytochrome c oxidase subunit 8A, mitochondrial precursor

      See identical proteins and their annotated locations for NP_031776.1

      Status: VALIDATED

      Source sequence(s)
      AAHY01141457, AK002218
      Consensus CDS
      CCDS29521.1
      UniProtKB/Swiss-Prot
      Q64445
      Related
      ENSMUSP00000040717.4, ENSMUST00000039758.4
      Conserved Domains (1) summary
      pfam02285
      Location:2767
      COX8; Cytochrome oxidase c subunit VIII

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000085.6 Reference GRCm38.p4 C57BL/6J

      Range
      7215158..7217616 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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