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    IQGAP3 IQ motif containing GTPase activating protein 3 [ Homo sapiens (human) ]

    Gene ID: 128239, updated on 20-May-2024

    Summary

    Official Symbol
    IQGAP3provided by HGNC
    Official Full Name
    IQ motif containing GTPase activating protein 3provided by HGNC
    Primary source
    HGNC:HGNC:20669
    See related
    Ensembl:ENSG00000183856 AllianceGenome:HGNC:20669
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Enables calmodulin binding activity and myosin VI light chain binding activity. Predicted to be involved in regulation of actin cytoskeleton organization. Predicted to act upstream of or within several processes, including intracellular signal transduction; positive regulation of macromolecule metabolic process; and positive regulation of mammary gland epithelial cell proliferation. Predicted to be located in cytosol. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in bone marrow (RPKM 5.6), duodenum (RPKM 3.0) and 16 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See IQGAP3 in Genome Data Viewer
    Location:
    1q22
    Exon count:
    40
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (156525405..156572565, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (155663992..155708965, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (156495197..156542357, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene MIR9-1 host gene Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:156390239-156390770 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1426 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1427 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:156391951-156392452 Neighboring gene microRNA 9-1 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr1:156409392-156409986 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:156409987-156410580 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1860 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:156418512-156419012 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1861 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:156426495-156427452 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:156427509-156428010 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:156428011-156428510 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:156431759-156432710 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:156432711-156433660 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:156445026-156445638 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1863 Neighboring gene myocyte enhancer factor 2D Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1864 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1865 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1866 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1867 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:156466171-156466671 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1428 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:156471045-156471824 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1429 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1868 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:156474933-156475335 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1869 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1870 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:156483472-156483678 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1430 Neighboring gene OCT4-H3K4me1 hESC enhancer GRCh37_chr1:156495835-156496406 Neighboring gene small nucleolar RNA U13 Neighboring gene NANOG hESC enhancer GRCh37_chr1:156508711-156509291 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1871 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1872 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1873 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:156554411-156554912 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:156554913-156555412 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:156561722-156562568 Neighboring gene tetratricopeptide repeat domain 24 Neighboring gene NAD(P)HX epimerase

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC1947, MGC10170, MGC10831

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables calmodulin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables calmodulin binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables myosin VI light chain binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables small GTPase binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in ERK1 and ERK2 cascade IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in G1/S transition of mitotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in Ras protein signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to organic substance IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in gene expression IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in mammary gland epithelial cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in mitotic actomyosin contractile ring assembly actin filament organization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of gene expression IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of MAPK cascade IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of gene expression IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of mammary gland epithelial cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of cell size IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in cell cortex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cell-cell junction IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in lateral plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    ras GTPase-activating-like protein IQGAP3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_178229.5NP_839943.3  ras GTPase-activating-like protein IQGAP3

      Status: VALIDATED

      Source sequence(s)
      AL365181
      Consensus CDS
      CCDS1144.1
      UniProtKB/Swiss-Prot
      Q5T3H8, Q86VI3
      UniProtKB/TrEMBL
      A2RRC9
      Related
      ENSP00000354451.2, ENST00000361170.7
      Conserved Domains (3) summary
      cd12207
      Location:9871336
      RasGAP_IQGAP3; Ras-GTPase Activating Domain of IQ motif containing GTPase activating protein 3
      cl27227
      Location:8611631
      RasGAP_C; RasGAP C-terminus
      cl27381
      Location:734957
      Myosin_head; Myosin head (motor domain)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      156525405..156572565 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047445996.1XP_047301952.1  ras GTPase-activating-like protein IQGAP3 isoform X3

    2. XM_047445990.1XP_047301946.1  ras GTPase-activating-like protein IQGAP3 isoform X2

    3. XM_011509198.4XP_011507500.1  ras GTPase-activating-like protein IQGAP3 isoform X1

      UniProtKB/TrEMBL
      A2RRC9
      Conserved Domains (5) summary
      smart00015
      Location:768785
      IQ; Calmodulin-binding motif
      cd12207
      Location:9921341
      RasGAP_IQGAP3; Ras-GTPase Activating Domain of IQ motif containing GTPase activating protein 3
      smart00323
      Location:9811334
      RasGAP; GTPase-activator protein for Ras-like GTPases
      cd00014
      Location:40152
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      pfam03836
      Location:14531559
      RasGAP_C; RasGAP C-terminus
    4. XM_047446003.1XP_047301959.1  ras GTPase-activating-like protein IQGAP3 isoform X4

    5. XM_011509201.2XP_011507503.1  ras GTPase-activating-like protein IQGAP3 isoform X6

      Conserved Domains (4) summary
      smart00015
      Location:267284
      IQ; Calmodulin-binding motif
      cd12207
      Location:491840
      RasGAP_IQGAP3; Ras-GTPase Activating Domain of IQ motif containing GTPase activating protein 3
      smart00323
      Location:480833
      RasGAP; GTPase-activator protein for Ras-like GTPases
      pfam03836
      Location:9521058
      RasGAP_C; RasGAP C-terminus
    6. XM_011509200.3XP_011507502.1  ras GTPase-activating-like protein IQGAP3 isoform X5

      Conserved Domains (4) summary
      smart00015
      Location:321338
      IQ; Calmodulin-binding motif
      cd12207
      Location:545894
      RasGAP_IQGAP3; Ras-GTPase Activating Domain of IQ motif containing GTPase activating protein 3
      smart00323
      Location:534887
      RasGAP; GTPase-activator protein for Ras-like GTPases
      pfam03836
      Location:10061112
      RasGAP_C; RasGAP C-terminus

    Reference GRCh38.p14 PATCHES

    Genomic

    1. NW_025791758.1 Reference GRCh38.p14 PATCHES

      Range
      83962..131166 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054332827.1XP_054188802.1  ras GTPase-activating-like protein IQGAP3 isoform X1

    2. XM_054332828.1XP_054188803.1  ras GTPase-activating-like protein IQGAP3 isoform X2

    3. XM_054332829.1XP_054188804.1  ras GTPase-activating-like protein IQGAP3 isoform X3

    4. XM_054332830.1XP_054188805.1  ras GTPase-activating-like protein IQGAP3 isoform X4

    5. XM_054332832.1XP_054188807.1  ras GTPase-activating-like protein IQGAP3 isoform X6

    6. XM_054332831.1XP_054188806.1  ras GTPase-activating-like protein IQGAP3 isoform X5

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      155663992..155708965 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054334424.1XP_054190399.1  ras GTPase-activating-like protein IQGAP3 isoform X1

    2. XM_054334425.1XP_054190400.1  ras GTPase-activating-like protein IQGAP3 isoform X2

    3. XM_054334422.1XP_054190397.1  ras GTPase-activating-like protein IQGAP3 isoform X8

    4. XM_054334421.1XP_054190396.1  ras GTPase-activating-like protein IQGAP3 isoform X7

    5. XM_054334426.1XP_054190401.1  ras GTPase-activating-like protein IQGAP3 isoform X3

    6. XM_054334423.1XP_054190398.1  ras GTPase-activating-like protein IQGAP3 isoform X9

    7. XM_054334427.1XP_054190402.1  ras GTPase-activating-like protein IQGAP3 isoform X10

    8. XM_054334429.1XP_054190404.1  ras GTPase-activating-like protein IQGAP3 isoform X6

    9. XM_054334428.1XP_054190403.1  ras GTPase-activating-like protein IQGAP3 isoform X5