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    Clk2 CDC-like kinase 2 [ Mus musculus (house mouse) ]

    Gene ID: 12748, updated on 23-Jun-2021

    Summary

    Official Symbol
    Clk2provided by MGI
    Official Full Name
    CDC-like kinase 2provided by MGI
    Primary source
    MGI:MGI:1098669
    See related
    Ensembl:ENSMUSG00000068917
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AU041688
    Expression
    Ubiquitous expression in limb E14.5 (RPKM 37.3), CNS E11.5 (RPKM 31.9) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Clk2 in Genome Data Viewer
    Location:
    3; 3 F1
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (89072102..89084394)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (89164795..89177087)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 3 NC_000069.5 (88968727..88981009)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 29704 Neighboring gene pyruvate kinase liver and red blood cell Neighboring gene hyperpolarization-activated, cyclic nucleotide-gated K+ 3 Neighboring gene predicted gene, 45927 Neighboring gene secretory carrier membrane protein 3 Neighboring gene predicted gene 16069 Neighboring gene family with sequence similarity 189, member B Neighboring gene predicted gene, 23269

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Targeted (1)  1 citation
    • Endonuclease-mediated (1) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Readthrough Gm45927

    Readthrough gene: Gm45927, Included gene: Scamp3

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein serine/threonine/tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein tyrosine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    dual specificity protein kinase CLK2
    NP_001156904.1
    NP_031738.2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001163432.2NP_001156904.1  dual specificity protein kinase CLK2 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
      Source sequence(s)
      AC161600, BY021174, BY247622, BY738871, CD740936, CN538691, DT924403
      Consensus CDS
      CCDS50958.1
      UniProtKB/TrEMBL
      F8WHX0
      Related
      ENSMUSP00000088445.6, ENSMUST00000090927.12
      Conserved Domains (2) summary
      smart00220
      Location:161477
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14215
      Location:148477
      PKc_CLK2; Catalytic domain of the Dual-specificity protein kinase, CDC-like kinase 2
    2. NM_007712.4NP_031738.2  dual specificity protein kinase CLK2 isoform 1

      See identical proteins and their annotated locations for NP_031738.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC161600, BY021174, BY247622, BY738871, CD740936, CN538691, DT924403
      Consensus CDS
      CCDS17491.1
      UniProtKB/Swiss-Prot
      O35491
      Related
      ENSMUSP00000113390.3, ENSMUST00000121212.9
      Conserved Domains (2) summary
      smart00220
      Location:162478
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14215
      Location:149478
      PKc_CLK2; Catalytic domain of the Dual-specificity protein kinase, CDC-like kinase 2

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      89072102..89084394
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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