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    Clns1a chloride channel, nucleotide-sensitive, 1A [ Mus musculus (house mouse) ]

    Gene ID: 12729, updated on 23-Jun-2021

    Summary

    Official Symbol
    Clns1aprovided by MGI
    Official Full Name
    chloride channel, nucleotide-sensitive, 1Aprovided by MGI
    Primary source
    MGI:MGI:109638
    See related
    Ensembl:ENSMUSG00000025439
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    I; Cl; Clci; ICLN; Clcni; 2610036D06Rik; 2610100O04Rik
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 20.0), CNS E14 (RPKM 15.6) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Clns1a in Genome Data Viewer
    Location:
    7 E1; 7 53.57 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (97345864..97370000)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (97696657..97720793)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (104845201..104867389)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene remodeling and spacing factor 1 Neighboring gene remodeling and spacing factor 1, opposite strand 1 Neighboring gene remodeling and spacing factor 1, opposite strand 2 Neighboring gene aquaporin 11 Neighboring gene p21 (RAC1) activated kinase 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in cell volume homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in chloride transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mRNA cis splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in negative regulation of cell volume IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in spliceosomal snRNP assembly ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    part_of methylosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    part_of pICln-Sm protein complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    part_of spliceosomal complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    methylosome subunit pICln
    Names
    chloride channel current inducer
    chloride channel regulator
    chloride conductance regulatory protein ICln
    chloride ion current inducer protein
    i(Cln)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_023671.2NP_076160.1  methylosome subunit pICln

      See identical proteins and their annotated locations for NP_076160.1

      Status: VALIDATED

      Source sequence(s)
      AC151477, AK169259, CX236388
      Consensus CDS
      CCDS21462.1
      UniProtKB/TrEMBL
      Q923F1
      Related
      ENSMUSP00000026506.5, ENSMUST00000026506.5
      Conserved Domains (1) summary
      pfam03517
      Location:40141
      Voldacs; Regulator of volume decrease after cellular swelling

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      97345864..97370000
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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