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    Clns1a chloride channel, nucleotide-sensitive, 1A [ Mus musculus (house mouse) ]

    Gene ID: 12729, updated on 31-Jan-2019

    Summary

    Official Symbol
    Clns1aprovided by MGI
    Official Full Name
    chloride channel, nucleotide-sensitive, 1Aprovided by MGI
    Primary source
    MGI:MGI:109638
    See related
    Ensembl:ENSMUSG00000025439
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Clci; ICLN; Clcni; 2610036D06Rik; 2610100O04Rik
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 20.0), CNS E14 (RPKM 15.6) and 28 other tissues See more
    Orthologs

    Genomic context

    See Clns1a in Genome Data Viewer
    Location:
    7 E1; 7 53.57 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 7 NC_000073.6 (97696657..97720793)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (104845201..104867389)

    Chromosome 7 - NC_000073.6Genomic Context describing neighboring genes Neighboring gene remodeling and spacing factor 1 Neighboring gene remodeling and spacing factor 1, opposite strand 1 Neighboring gene remodeling and spacing factor 1, opposite strand 2 Neighboring gene aquaporin 11 Neighboring gene predicted gene, 39050

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    protein heterodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    Process Evidence Code Pubs
    cell volume homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    chloride transport ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cell volume IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    spliceosomal snRNP assembly ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    methylosome ISO
    Inferred from Sequence Orthology
    more info
     
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    pICln-Sm protein complex ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    methylosome subunit pICln
    Names
    chloride channel current inducer
    chloride channel regulator
    chloride conductance regulatory protein ICln
    chloride ion current inducer protein
    i(Cln)

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_023671.2NP_076160.1  methylosome subunit pICln

      See identical proteins and their annotated locations for NP_076160.1

      Status: VALIDATED

      Source sequence(s)
      AC151477, AK169259, CX236388
      Consensus CDS
      CCDS21462.1
      UniProtKB/TrEMBL
      Q923F1
      Related
      ENSMUSP00000026506.4, ENSMUST00000026506.4
      Conserved Domains (1) summary
      pfam03517
      Location:40141
      Voldacs; Regulator of volume decrease after cellular swelling

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000073.6 Reference GRCm38.p4 C57BL/6J

      Range
      97696657..97720793
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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