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    OR2M3 olfactory receptor family 2 subfamily M member 3 [ Homo sapiens (human) ]

    Gene ID: 127062, updated on 10-Dec-2024

    Summary

    Official Symbol
    OR2M3provided by HGNC
    Official Full Name
    olfactory receptor family 2 subfamily M member 3provided by HGNC
    Primary source
    HGNC:HGNC:8269
    See related
    Ensembl:ENSG00000228198 AllianceGenome:HGNC:8269
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    OR2M6; OR1-54; OR2M3P; OST003
    Summary
    Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]
    Orthologs
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    Genomic context

    See OR2M3 in Genome Data Viewer
    Location:
    1q44
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (248197265..248212925)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (247623456..247639115)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (248360567..248376227)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene akirin 2 pseudogene Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:248334985-248335547 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:248335548-248336109 Neighboring gene olfactory receptor family 2 subfamily M member 2 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr1:248349804-248351003 Neighboring gene olfactory receptor family 2 subfamily M member 4 Neighboring gene olfactory receptor family 2 subfamily T member 33

    Genomic regions, transcripts, and products

    General gene information

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables olfactory receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in detection of chemical stimulus involved in sensory perception of smell IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    olfactory receptor 2M3
    Names
    novel 7 transmembrane receptor (rhodopsin family) protein
    olfactory receptor 2M6
    olfactory receptor OR1-54
    olfactory receptor, family 2, subfamily M, member 3 pseudogene
    olfactory receptor, family 2, subfamily M, member 6

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001004689.2NP_001004689.1  olfactory receptor 2M3

      See identical proteins and their annotated locations for NP_001004689.1

      Status: VALIDATED

      Source sequence(s)
      AL450303
      Consensus CDS
      CCDS31107.1
      UniProtKB/Swiss-Prot
      B9EH06, Q6IEY0, Q8NG83
      UniProtKB/TrEMBL
      A0A126GV67, A0A126GVX9
      Related
      ENSP00000492981.1, ENST00000641626.1
      Conserved Domains (2) summary
      pfam00001
      Location:41290
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:33305
      7tm_4; Olfactory receptor

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      248197265..248212925
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      247623456..247639115
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)