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    Cirbp cold inducible RNA binding protein [ Mus musculus (house mouse) ]

    Gene ID: 12696, updated on 3-Mar-2019

    Summary

    Official Symbol
    Cirbpprovided by MGI
    Official Full Name
    cold inducible RNA binding proteinprovided by MGI
    Primary source
    MGI:MGI:893588
    See related
    Ensembl:ENSMUSG00000045193
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Cirp; R74941
    Expression
    Ubiquitous expression in CNS E14 (RPKM 77.5), whole brain E14.5 (RPKM 68.5) and 28 other tissues See more
    Orthologs

    Genomic context

    See Cirbp in Genome Data Viewer
    Location:
    10 C1; 10 39.72 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 10 NC_000076.6 (80165990..80172691)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 10 NC_000076.5 (79630586..79634398)

    Chromosome 10 - NC_000076.6Genomic Context describing neighboring genes Neighboring gene calcium channel, voltage-dependent, beta subunit associated regulatory protein Neighboring gene ATP synthase, H+ transporting, mitochondrial F1 complex, delta subunit Neighboring gene midnolin Neighboring gene RIKEN cDNA 1600002K03 gene Neighboring gene ephrin A2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    • mRNA processing, organism-specific biosystem (from WikiPathways)
      mRNA processing, organism-specific biosystemAdapted from Reactome, see: [http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_1675.1 REACT 1675.1] This process describes the conversion of precursor messenger RNA into mature messenge...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    RNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mRNA 3'-UTR binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    mRNA 3'-UTR binding ISO
    Inferred from Sequence Orthology
    more info
     
    nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
     
    poly(U) RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    poly(U) RNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    small ribosomal subunit rRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    small ribosomal subunit rRNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    translation repressor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    translation repressor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    cellular response to cold IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mRNA stabilization ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cell growth IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of translation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of translation ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of cell cycle G1/S phase transition IDA
    Inferred from Direct Assay
    more info
    PubMed 
    response to UV ISO
    Inferred from Sequence Orthology
    more info
     
    response to cold IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    stress granule assembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasmic stress granule IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleolus ISO
    Inferred from Sequence Orthology
    more info
     
    nucleoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    ribonucleoprotein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    spliceosomal complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    cold-inducible RNA-binding protein
    Names
    A18 hnRNP
    glycine-rich RNA-binding protein CIRP

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_007705.3NP_031731.1  cold-inducible RNA-binding protein

      See identical proteins and their annotated locations for NP_031731.1

      Status: VALIDATED

      Source sequence(s)
      AI841072, AK132584
      Consensus CDS
      CCDS35975.1
      UniProtKB/Swiss-Prot
      P60824
      Related
      ENSMUSP00000101004.2, ENSMUST00000105365.8
      Conserved Domains (1) summary
      cd12449
      Location:685
      RRM_CIRBP_RBM3; RNA recognition motif in cold inducible RNA binding protein (CIRBP), RNA binding motif protein 3 (RBM3) and similar proteins

    RNA

    1. NR_152857.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC159999, BC075699, BE985260, BQ445205, CJ046415

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000076.6 Reference GRCm38.p4 C57BL/6J

      Range
      80165990..80172691
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006513165.1XP_006513228.1  cold-inducible RNA-binding protein isoform X1

      See identical proteins and their annotated locations for XP_006513228.1

      Conserved Domains (2) summary
      COG0724
      Location:390
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12449
      Location:685
      RRM_CIRBP_RBM3; RNA recognition motif in cold inducible RNA binding protein (CIRBP), RNA binding motif protein 3 (RBM3) and similar proteins
    2. XM_006513164.1XP_006513227.1  cold-inducible RNA-binding protein isoform X1

      See identical proteins and their annotated locations for XP_006513227.1

      Conserved Domains (2) summary
      COG0724
      Location:390
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12449
      Location:685
      RRM_CIRBP_RBM3; RNA recognition motif in cold inducible RNA binding protein (CIRBP), RNA binding motif protein 3 (RBM3) and similar proteins

    RNA

    1. XR_380351.1 RNA Sequence

      Related
      ENSMUST00000054666.6
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