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    Chuk conserved helix-loop-helix ubiquitous kinase [ Mus musculus (house mouse) ]

    Gene ID: 12675, updated on 3-Aug-2021

    Summary

    Official Symbol
    Chukprovided by MGI
    Official Full Name
    conserved helix-loop-helix ubiquitous kinaseprovided by MGI
    Primary source
    MGI:MGI:99484
    See related
    Ensembl:ENSMUSG00000025199
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    IKK; IKK-; IKK1; IKK[; Ikka; Chuk1; Fbx24; IKBKA; Fbxo24; NFKBIKA; AI256658; IKK alpha
    Expression
    Ubiquitous expression in CNS E18 (RPKM 12.2), CNS E14 (RPKM 11.6) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Chuk in Genome Data Viewer
    Location:
    19 C3; 19 36.71 cM
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (44061773..44095940, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (44073334..44107505, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 19 NC_000085.5 (44147824..44181967, complement)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene cytochrome P450, family 2, subfamily c, polypeptide 23 Neighboring gene ER lipid raft associated 1 Neighboring gene uracil DNA glycosylase pseudogene Neighboring gene CWF19-like 1, cell cycle control (S. pombe) Neighboring gene predicted gene, 24336 Neighboring gene predicted gene, 52383

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (9)  1 citation
    • Endonuclease-mediated (1) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC25325

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    contributes_to IkappaB kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    contributes_to IkappaB kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein heterodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables scaffold protein binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables transferrin receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in I-kappaB kinase/NF-kappaB signaling ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within I-kappaB phosphorylation TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in NIK/NF-kappaB signaling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in Rho protein signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to cadmium ion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to reactive oxygen species ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to tumor necrosis factor ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to virus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cellular response to virus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in defense response to virus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within lactation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within lactation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within mammary gland alveolus development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within mammary gland alveolus development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within mammary gland epithelial cell proliferation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within mammary gland epithelial cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within morphogenesis of an epithelial sheet IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of NF-kappaB transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within odontogenesis of dentin-containing tooth IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within osteoclast differentiation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within osteoclast differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in peptidyl-serine phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within positive regulation of I-kappaB kinase/NF-kappaB signaling IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of I-kappaB kinase/NF-kappaB signaling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of I-kappaB kinase/NF-kappaB signaling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of NF-kappaB transcription factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in positive regulation of interferon-alpha production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of interferon-alpha production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to cholecystokinin ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to lipopolysaccharide ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within response to muscle stretch IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in response to organic substance ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in striated muscle cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in tumor necrosis factor-mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of CD40 receptor complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of IkappaB kinase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of IkappaB kinase complex ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in cytoplasmic side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    inhibitor of nuclear factor kappa-B kinase subunit alpha
    Names
    I kappa B kinase 1
    I-kappa-B kinase alpha
    IkappaB kinase alpha
    nuclear factor NF-kappa-B inhibitor kinase alpha
    NP_001155882.1
    NP_031726.2
    XP_030106592.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001162410.1NP_001155882.1  inhibitor of nuclear factor kappa-B kinase subunit alpha isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region compared to variant 1, that results in a frameshift. The encoded isoform (2) is shorter and has a distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AC124693, AK035326, AK164236
      Consensus CDS
      CCDS50444.1
      UniProtKB/TrEMBL
      E9Q605, Q3TPN9, Q8CBT3
      Related
      ENSMUSP00000113809.2, ENSMUST00000119591.2
      Conserved Domains (2) summary
      smart00220
      Location:15298
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14039
      Location:21309
      STKc_IKK_alpha; Catalytic domain of the Serine/Threonine kinase, Inhibitor of Nuclear Factor-KappaB Kinase (IKK) alpha
    2. NM_007700.2NP_031726.2  inhibitor of nuclear factor kappa-B kinase subunit alpha isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC124693, AK035326, AK150039, AK164236
      Consensus CDS
      CCDS29843.1
      UniProtKB/TrEMBL
      E9QNL4, Q3TPN9, Q3UDK0, Q8CBT3
      Related
      ENSMUSP00000026217.5, ENSMUST00000026217.11
      Conserved Domains (3) summary
      smart00220
      Location:15298
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14039
      Location:21309
      STKc_IKK_alpha; Catalytic domain of the Serine/Threonine kinase, Inhibitor of Nuclear Factor-KappaB Kinase (IKK) alpha
      pfam12179
      Location:709743
      IKKbetaNEMObind; I-kappa-kinase-beta NEMO binding domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      44061773..44095940 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030250732.2XP_030106592.1  inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1

      Conserved Domains (3) summary
      cd14039
      Location:21309
      STKc_IKK_alpha; Catalytic domain of the Serine/Threonine kinase, Inhibitor of Nuclear Factor-KappaB Kinase (IKK) alpha
      cd17046
      Location:311387
      Ubl_IKKA_like; ubiquitin-like (Ubl) domain found in inhibitor of nuclear factor kappa-B kinases, IKK-alpha and IKK-beta, and similar proteins
      pfam18397
      Location:386659
      IKBKB_SDD; IQBAL scaffold dimerization domain

    RNA

    1. XR_003952742.2 RNA Sequence

    2. XR_003952741.2 RNA Sequence

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