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    HSPB6 heat shock protein family B (small) member 6 [ Homo sapiens (human) ]

    Gene ID: 126393, updated on 3-Jun-2024

    Summary

    Official Symbol
    HSPB6provided by HGNC
    Official Full Name
    heat shock protein family B (small) member 6provided by HGNC
    Primary source
    HGNC:HGNC:26511
    See related
    Ensembl:ENSG00000004776 MIM:610695; AllianceGenome:HGNC:26511
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HEL55; Hsp20; PPP1R91
    Summary
    This locus encodes a heat shock protein. The encoded protein likely plays a role in smooth muscle relaxation. [provided by RefSeq, Jan 2012]
    Expression
    Biased expression in fat (RPKM 483.5), heart (RPKM 239.6) and 8 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See HSPB6 in Genome Data Viewer
    Location:
    19q13.12
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (35754566..35757029, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (38299879..38302342, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (36245467..36247930, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:36238731-36239245 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:36239246-36239760 Neighboring gene presenilin enhancer, gamma-secretase subunit Neighboring gene lin-37 DREAM MuvB core complex component Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:36248182-36248753 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14500 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14501 Neighboring gene proline and serine rich 3 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:36257953-36258804 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14502 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10539 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:36268039-36268924 Neighboring gene Rho GTPase activating protein 33 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:36268925-36269809 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:36275082-36275900

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ32389

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein folding chaperone IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein homodimerization activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein-folding chaperone binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables structural constituent of eye lens IEA
    Inferred from Electronic Annotation
    more info
     
    enables unfolded protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables unfolded protein binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in chaperone-mediated protein folding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of angiogenesis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein refolding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in response to heat IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    located_in extracellular region IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
     
    located_in nuclear speck IDA
    Inferred from Direct Assay
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    heat shock protein beta-6
    Names
    epididymis luminal protein 55
    epididymis secretory sperm binding protein
    heat shock 20 kDa-like protein p20
    heat shock protein family B (small) member B6
    heat shock protein, alpha-crystallin-related, B6
    protein phosphatase 1, regulatory subunit 91

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_031983.2 RefSeqGene

      Range
      5001..7464
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_144617.3NP_653218.1  heat shock protein beta-6

      See identical proteins and their annotated locations for NP_653218.1

      Status: REVIEWED

      Source sequence(s)
      AK026458, AK056951, BC068046
      Consensus CDS
      CCDS12475.1
      UniProtKB/Swiss-Prot
      O14551, O14558, Q6NVI3, Q96MG9
      UniProtKB/TrEMBL
      A0A384MEB1, V9HWB6
      Related
      ENSP00000004982.3, ENST00000004982.6
      Conserved Domains (2) summary
      cd06478
      Location:66144
      ACD_HspB4-5-6; Alpha-crystallin domain found in alphaA-crystallin (HspB4), alphaB-crystallin (HspB5), and the small heat shock protein (sHsp) HspB6, also known as Hsp20. sHsps are molecular chaperones that suppress protein aggregation and protect against cell stress, ...
      pfam00525
      Location:358
      Crystallin; Alpha crystallin A chain, N terminal

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      35754566..35757029 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      38299879..38302342 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)