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    Cfl1 cofilin 1, non-muscle [ Mus musculus (house mouse) ]

    Gene ID: 12631, updated on 6-Nov-2018

    Summary

    Official Symbol
    Cfl1provided by MGI
    Official Full Name
    cofilin 1, non-muscleprovided by MGI
    Primary source
    MGI:MGI:101757
    See related
    Ensembl:ENSMUSG00000056201 Vega:OTTMUSG00000060221
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Cof; AA959946
    Expression
    Ubiquitous expression in CNS E18 (RPKM 655.5), CNS E11.5 (RPKM 635.5) and 28 other tissues See more
    Orthologs

    Genomic context

    See Cfl1 in Genome Data Viewer
    Location:
    19; 19 A
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 19 NC_000085.6 (5490455..5494031)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 19 NC_000085.5 (5490455..5494031)

    Chromosome 19 - NC_000085.6Genomic Context describing neighboring genes Neighboring gene epidermal growth factor-containing fibulin-like extracellular matrix protein 2 Neighboring gene MUS81 structure-specific endonuclease subunit Neighboring gene RIKEN cDNA 1700020D05 gene Neighboring gene sorting nexin 32 Neighboring gene predicted gene, 31166 Neighboring gene ovo like zinc finger 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    actin binding ISO
    Inferred from Sequence Orthology
    more info
     
    actin filament binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    actin filament binding ISO
    Inferred from Sequence Orthology
    more info
     
    phosphatidylinositol bisphosphate binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein phosphatase binding ISO
    Inferred from Sequence Orthology
    more info
     
    signaling receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    actin filament depolymerization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    actin filament depolymerization ISO
    Inferred from Sequence Orthology
    more info
     
    actin filament fragmentation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    actin filament organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cell projection organization ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    cellular response to epidermal growth factor stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to hydrogen peroxide ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to insulin-like growth factor stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to interleukin-1 ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to interleukin-6 ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to tumor necrosis factor ISO
    Inferred from Sequence Orthology
    more info
     
    cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
     
    establishment of cell polarity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    mitotic cytokinesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    modification of postsynaptic actin cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
     
    movement of cell or subcellular component IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of actin filament bundle assembly ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of actin filament depolymerization ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cell adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cell motility ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cell size ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    negative regulation of dendritic spine maintenance ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of lamellipodium assembly ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of postsynaptic density organization ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of unidimensional cell growth ISO
    Inferred from Sequence Orthology
    more info
     
    neural crest cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    neural fold formation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation by host of viral process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of NMDA glutamate receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of actin filament depolymerization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of actin filament depolymerization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of barbed-end actin filament capping ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cell growth ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cell motility ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of dendritic spine development ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of establishment of cell polarity regulating cell shape ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of focal adhesion assembly ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of lamellipodium assembly ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein localization to cell leading edge ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of proteolysis ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of synaptic plasticity ISO
    Inferred from Sequence Orthology
    more info
     
    protein import into nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of cell morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of dendritic spine morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    response to amino acid IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    actin cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    cell leading edge ISO
    Inferred from Sequence Orthology
    more info
     
    cell projection IEA
    Inferred from Electronic Annotation
    more info
     
    cell-cell junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cofilin-actin rod ISO
    Inferred from Sequence Orthology
    more info
     
    cortical actin cytoskeleton IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    dendritic spine ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular space HDA PubMed 
    filopodium ISO
    Inferred from Sequence Orthology
    more info
     
    glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
     
    growth cone ISO
    Inferred from Sequence Orthology
    more info
     
    intracellular IEA
    Inferred from Electronic Annotation
    more info
     
    lamellipodium IDA
    Inferred from Direct Assay
    more info
    PubMed 
    lamellipodium ISO
    Inferred from Sequence Orthology
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    mitochondrial membrane ISO
    Inferred from Sequence Orthology
    more info
     
    neuron projection ISO
    Inferred from Sequence Orthology
    more info
     
    neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    synaptic membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    cofilin-1
    Names
    cofilin, non-muscle isoform
    n-cofilin

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_007687.5NP_031713.1  cofilin-1

      See identical proteins and their annotated locations for NP_031713.1

      Status: VALIDATED

      Source sequence(s)
      AI844923, BC058726, CX218255
      Consensus CDS
      CCDS84409.1
      UniProtKB/Swiss-Prot
      P18760
      UniProtKB/TrEMBL
      Q544Y7
      Related
      ENSMUSP00000147514.1, OTTMUSP00000076712, ENSMUST00000209469.1, OTTMUST00000147413
      Conserved Domains (1) summary
      cd11286
      Location:3153
      ADF_cofilin_like; Cofilin, Destrin, and related actin depolymerizing factors

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000085.6 Reference GRCm38.p4 C57BL/6J

      Range
      5490455..5494031
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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