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    Cenpa centromere protein A [ Mus musculus (house mouse) ]

    Gene ID: 12615, updated on 12-Mar-2019

    Summary

    Official Symbol
    Cenpaprovided by MGI
    Official Full Name
    centromere protein Aprovided by MGI
    Primary source
    MGI:MGI:88375
    See related
    Ensembl:ENSMUSG00000029177
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Cenp-A
    Summary
    Centromeres are the differentiated chromosomal domains that specify the mitotic behavior of chromosomes. This gene encodes a centromere protein which contains a histone H3 related histone fold domain that is required for targeting to the centromere. Centromere protein A is proposed to be a component of a modified nucleosome or nucleosome-like structure in which it replaces 1 or both copies of conventional histone H3 in the (H3-H4)2 tetrameric core of the nucleosome particle. The protein is a replication-independent histone that is a member of the histone H3 family. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Nov 2015]
    Expression
    Broad expression in CNS E11.5 (RPKM 43.5), liver E14.5 (RPKM 41.9) and 20 other tissues See more
    Orthologs

    Genomic context

    See Cenpa in Genome Data Viewer
    Location:
    5 B1; 5 16.76 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 5 NC_000071.6 (30666886..30674837)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (30969275..30977199)

    Chromosome 5 - NC_000071.6Genomic Context describing neighboring genes Neighboring gene predicted gene 9899 Neighboring gene potassium channel, subfamily K, member 3 Neighboring gene microRNA 5625 Neighboring gene solute carrier family 35, member F6 Neighboring gene autophagy-related 3 pseudogene Neighboring gene dihydropyrimidinase-like 5 Neighboring gene predicted gene, 46907

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    nucleosomal DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein heterodimerization activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    establishment of mitotic spindle orientation ISO
    Inferred from Sequence Orthology
    more info
     
    kinetochore assembly ISO
    Inferred from Sequence Orthology
    more info
     
    mitotic cytokinesis ISO
    Inferred from Sequence Orthology
    more info
     
    protein localization to chromosome, centromeric region ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    chromosome IEA
    Inferred from Electronic Annotation
    more info
     
    chromosome, centromeric region IDA
    Inferred from Direct Assay
    more info
    PubMed 
    chromosome, centromeric region ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    condensed chromosome inner kinetochore IDA
    Inferred from Direct Assay
    more info
    PubMed 
    condensed nuclear chromosome kinetochore ISO
    Inferred from Sequence Orthology
    more info
     
    condensed nuclear chromosome, centromeric region IDA
    Inferred from Direct Assay
    more info
    PubMed 
    condensed nuclear chromosome, centromeric region ISO
    Inferred from Sequence Orthology
    more info
     
    kinetochore IEA
    Inferred from Electronic Annotation
    more info
     
    nuclear nucleosome ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear pericentric heterochromatin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    histone H3-like centromeric protein A
    Names
    centromere autoantigen A
    centrosomin A

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001302129.1NP_001289058.1  histone H3-like centromeric protein A isoform 2

      See identical proteins and their annotated locations for NP_001289058.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) contains an alternate exon in the 5' coding region and uses a downstream start codon compared to variant 1. The resulting isoform (2) has a distinct shorter N-terminus, compared to isoform 1. Variants 2, 3 and 4 encode the same isoform (2).
      Source sequence(s)
      AC105298, AF012709, AK011399, AK041138, BQ748418, BY136144
      UniProtKB/Swiss-Prot
      O35216
      Conserved Domains (2) summary
      smart00428
      Location:3105
      H3; Histone H3
      pfam00125
      Location:3101
      Histone; Core histone H2A/H2B/H3/H4
    2. NM_001302130.1NP_001289059.1  histone H3-like centromeric protein A isoform 2

      See identical proteins and their annotated locations for NP_001289059.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) contains two alternate exons in the 5' coding region and uses a downstream start codon compared to variant 1. The resulting isoform (2) has a distinct shorter N-terminus, compared to isoform 1. Variants 2, 3 and 4 encode the same isoform (2).
      Source sequence(s)
      AC105298, AF012709, AK011399, AK041138, BQ748418, BY136144
      UniProtKB/Swiss-Prot
      O35216
      Conserved Domains (2) summary
      smart00428
      Location:3105
      H3; Histone H3
      pfam00125
      Location:3101
      Histone; Core histone H2A/H2B/H3/H4
    3. NM_001302131.1NP_001289060.1  histone H3-like centromeric protein A isoform 2

      See identical proteins and their annotated locations for NP_001289060.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) contains two alternate exons in the 5' coding region and uses a downstream start codon compared to variant 1. The resulting isoform (2) has a distinct shorter N-terminus, compared to isoform 1. Variants 2, 3 and 4 encode the same isoform (2).
      Source sequence(s)
      AC105298, AF012709, AK011399, AK041138, BQ748418, BY136144
      UniProtKB/Swiss-Prot
      O35216
      Conserved Domains (2) summary
      smart00428
      Location:3105
      H3; Histone H3
      pfam00125
      Location:3101
      Histone; Core histone H2A/H2B/H3/H4
    4. NM_001302132.1NP_001289061.1  histone H3-like centromeric protein A isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) lacks a 3' exon, which results in a frameshift, compared to variant 1. The resulting isoform (3) has a shorter and distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AA016357, AC105298, AF012709, AK011399, BQ748418, BY136144
      UniProtKB/Swiss-Prot
      O35216
      Related
      ENSMUSP00000143575.1, ENSMUST00000199320.4
      Conserved Domains (2) summary
      pfam00125
      Location:192
      Histone; Core histone H2A/H2B/H3/H4
      cl23735
      Location:2890
      H4; Histone H4, one of the four histones, along with H2A, H2B and H3, which forms the eukaryotic nucleosome core; along with H3, it plays a central role in nucleosome formation; histones bind to DNA and wrap the genetic material into "beads on a string" in ...
    5. NM_007681.3NP_031707.1  histone H3-like centromeric protein A isoform 1

      See identical proteins and their annotated locations for NP_031707.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AC105298, AF012709, AK011399, BQ748418, BY136144
      Consensus CDS
      CCDS19162.1
      UniProtKB/Swiss-Prot
      O35216
      Related
      ENSMUSP00000122831.1, ENSMUST00000144742.5
      Conserved Domains (2) summary
      smart00428
      Location:28131
      H3; Histone H3
      pfam00125
      Location:1127
      Histone; Core histone H2A/H2B/H3/H4

    RNA

    1. NR_126074.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) uses an alternate splice site in the 3' region compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC105298, AF012709, AK011399, BQ748418, BY136144

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000071.6 Reference GRCm38.p4 C57BL/6J

      Range
      30666886..30674837
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011240699.2XP_011239001.1  histone H3-like centromeric protein A isoform X1

      Conserved Domains (2) summary
      smart00428
      Location:41143
      H3; Histone H3
      pfam00125
      Location:1139
      Histone; Core histone H2A/H2B/H3/H4
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