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    Cebpg CCAAT/enhancer binding protein gamma [ Mus musculus (house mouse) ]

    Gene ID: 12611, updated on 27-Nov-2024

    Summary

    Official Symbol
    Cebpgprovided by MGI
    Official Full Name
    CCAAT/enhancer binding protein gammaprovided by MGI
    Primary source
    MGI:MGI:104982
    See related
    Ensembl:ENSMUSG00000056216 AllianceGenome:MGI:104982
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gpe1bp; Ig/EBP; GPE1-BP; C/EBP[g]; C/EBPgamma
    Summary
    Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in hemopoiesis; natural killer cell mediated cytotoxicity; and regulation of gene expression. Acts upstream of or within mRNA metabolic process. Located in nucleus. Is expressed in several structures, including blood; central nervous system; genitourinary system; retina; and yolk sac. Orthologous to human CEBPG (CCAAT enhancer binding protein gamma). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in liver E18 (RPKM 10.2), CNS E11.5 (RPKM 8.7) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Cebpg in Genome Data Viewer
    Location:
    7 B2; 7 20.91 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (34745847..34755991, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (35046422..35056566, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene peptidase D Neighboring gene predicted gene, 25922 Neighboring gene STARR-seq mESC enhancer starr_18614 Neighboring gene predicted gene, 35534 Neighboring gene STARR-positive B cell enhancer ABC_E6536 Neighboring gene predicted gene 45095 Neighboring gene STARR-seq mESC enhancer starr_18615 Neighboring gene predicted gene, 35611 Neighboring gene CCAAT/enhancer binding protein alpha

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Targeted (2)  1 citation

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
     
    NOT enables DNA-binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables DNA-binding transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables DNA-binding transcription factor binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding, bending ISO
    Inferred from Sequence Orthology
    more info
     
    enables double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables sequence-specific DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables sequence-specific double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in B cell differentiation IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in chromatin remodeling TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in enucleate erythrocyte differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in immune response IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in liver development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within mRNA metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in natural killer cell mediated cytotoxicity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of DNA-binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in nucleosome disassembly TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in positive regulation of DNA repair ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of type II interferon production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    NOT acts_upstream_of_or_within regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of RNA polymerase II transcription regulator complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of RNA polymerase II transcription regulator complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    CCAAT/enhancer-binding protein gamma
    Names
    CCAAT/enhancer binding protein (C/EBP), gamma
    G-CSF promoter element 1 binding protein
    GPE1-BP (C/EBP gamma)
    GPE1-binding protein
    IG/EBP-1
    c/EBP gamma
    granulocyte colony-stimulating factor promoter element 1-binding protein
    immunoglobulin enhancer-binding protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_009884.3NP_034014.1  CCAAT/enhancer-binding protein gamma

      See identical proteins and their annotated locations for NP_034014.1

      Status: VALIDATED

      Source sequence(s)
      AC149058, AK159544, BE987706, CJ092456
      Consensus CDS
      CCDS21144.1
      UniProtKB/Swiss-Prot
      P53568
      UniProtKB/TrEMBL
      Q54AJ1
      Related
      ENSMUSP00000118588.2, ENSMUST00000130491.3
      Conserved Domains (1) summary
      cd14713
      Location:60120
      bZIP_CEBPG; Basic leucine zipper (bZIP) domain of CCAAT/enhancer-binding protein gamma (CEBPG): a DNA-binding and dimerization domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      34745847..34755991 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)