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    Cdk2 cyclin-dependent kinase 2 [ Mus musculus (house mouse) ]

    Gene ID: 12566, updated on 10-Aug-2021

    Summary

    Official Symbol
    Cdk2provided by MGI
    Official Full Name
    cyclin-dependent kinase 2provided by MGI
    Primary source
    MGI:MGI:104772
    See related
    Ensembl:ENSMUSG00000025358
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    A630093N05Rik
    Expression
    Broad expression in limb E14.5 (RPKM 35.9), thymus adult (RPKM 24.5) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Cdk2 in Genome Data Viewer
    Location:
    10; 10 D3
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (128533807..128540920, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (128697938..128705051, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 10 NC_000076.5 (128134995..128142107, complement)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene sulfite oxidase Neighboring gene ribosomal protein L12 pseudogene Neighboring gene RAB5B, member RAS oncogene family Neighboring gene premelanosome protein Neighboring gene diacylglycerol kinase, alpha Neighboring gene predicted gene, 31504 Neighboring gene PYM homolog 1, exon junction complex associated factor Neighboring gene ribosomal protein SA, pseudogene 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables cyclin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables cyclin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables cyclin binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables cyclin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables cyclin-dependent protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables cyclin-dependent protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables cyclin-dependent protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables cyclin-dependent protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    contributes_to histone kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables magnesium ion binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA repair IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in G1/S transition of mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within G1/S transition of mitotic cell cycle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within cell division IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within cellular response to DNA damage stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to insulin stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in centriole replication ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in histone phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within meiotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in peptidyl-serine phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in peptidyl-serine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within positive regulation of DNA-dependent DNA replication initiation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of cell population proliferation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in positive regulation of cell population proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of transcription, DNA-templated IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within potassium ion transport IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in protein phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of G2/M transition of mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in regulation of gene expression IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in regulation of gene silencing ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to cAMP ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to electrical stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in Cajal body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in X chromosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in Y chromosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in chromosome, telomeric region IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in condensed chromosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of cyclin A1-CDK2 complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of cyclin A1-CDK2 complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of cyclin A2-CDK2 complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of cyclin A2-CDK2 complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of cyclin E1-CDK2 complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of cyclin E1-CDK2 complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of cyclin E2-CDK2 complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of cyclin E2-CDK2 complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of cyclin-dependent protein kinase holoenzyme complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of cyclin-dependent protein kinase holoenzyme complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    part_of cyclin-dependent protein kinase holoenzyme complex ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    part_of transcription regulator complex IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    cyclin-dependent kinase 2
    Names
    cell division protein kinase 2
    NP_058036.1
    NP_904326.1
    XP_006513225.1
    XP_011241623.1
    XP_030100713.1
    XP_030100714.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_016756.4NP_058036.1  cyclin-dependent kinase 2 isoform 2

      See identical proteins and their annotated locations for NP_058036.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame coding exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AK152922, CN705407
      Consensus CDS
      CCDS24288.1
      UniProtKB/Swiss-Prot
      P97377
      UniProtKB/TrEMBL
      Q3U6X7
      Related
      ENSMUSP00000026415.8, ENSMUST00000026415.9
      Conserved Domains (1) summary
      cd07860
      Location:3286
      STKc_CDK2_3; Catalytic domain of the Serine/Threonine Kinases, Cyclin-Dependent protein Kinase 2 and 3
    2. NM_183417.3NP_904326.1  cyclin-dependent kinase 2 isoform 1

      See identical proteins and their annotated locations for NP_904326.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK148017, AK151979, AK152922, CN705407
      Consensus CDS
      CCDS24289.1
      UniProtKB/Swiss-Prot
      P97377
      UniProtKB/TrEMBL
      Q3U6X7, Q3UGB9
      Related
      ENSMUSP00000026416.8, ENSMUST00000026416.15
      Conserved Domains (1) summary
      cd07860
      Location:3334
      STKc_CDK2_3; Catalytic domain of the Serine/Threonine Kinases, Cyclin-Dependent protein Kinase 2 and 3

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      128533807..128540920 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011243321.4XP_011241623.1  cyclin-dependent kinase 2 isoform X1

      See identical proteins and their annotated locations for XP_011241623.1

      Conserved Domains (1) summary
      cl21453
      Location:1244
      PKc_like; Protein Kinases, catalytic domain
    2. XM_030244853.2XP_030100713.1  cyclin-dependent kinase 2 isoform X2

      Conserved Domains (1) summary
      cl21453
      Location:1196
      PKc_like; Protein Kinases, catalytic domain
    3. XM_030244854.1XP_030100714.1  cyclin-dependent kinase 2 isoform X2

      Conserved Domains (1) summary
      cl21453
      Location:1196
      PKc_like; Protein Kinases, catalytic domain
    4. XM_006513162.3XP_006513225.1  cyclin-dependent kinase 2 isoform X1

      See identical proteins and their annotated locations for XP_006513225.1

      Conserved Domains (1) summary
      cl21453
      Location:1244
      PKc_like; Protein Kinases, catalytic domain
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