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    Cdk2 cyclin-dependent kinase 2 [ Mus musculus (house mouse) ]

    Gene ID: 12566, updated on 31-Jan-2019

    Summary

    Official Symbol
    Cdk2provided by MGI
    Official Full Name
    cyclin-dependent kinase 2provided by MGI
    Primary source
    MGI:MGI:104772
    See related
    Ensembl:ENSMUSG00000025358
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    A630093N05Rik
    Expression
    Broad expression in limb E14.5 (RPKM 35.9), thymus adult (RPKM 24.5) and 25 other tissues See more
    Orthologs

    Genomic context

    See Cdk2 in Genome Data Viewer
    Location:
    10; 10 D3
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 10 NC_000076.6 (128697939..128705051, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 10 NC_000076.5 (128134995..128142107, complement)

    Chromosome 10 - NC_000076.6Genomic Context describing neighboring genes Neighboring gene ribosomal protein L12 pseudogene Neighboring gene RAB5B, member RAS oncogene family Neighboring gene premelanosome protein Neighboring gene diacylglycerol kinase, alpha Neighboring gene predicted gene, 31504

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    cyclin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cyclin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cyclin binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    cyclin binding ISO
    Inferred from Sequence Orthology
    more info
     
    cyclin-dependent protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    cyclin-dependent protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cyclin-dependent protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cyclin-dependent protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    contributes_to histone kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    magnesium ion binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    DNA repair IEA
    Inferred from Electronic Annotation
    more info
     
    G1/S transition of mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    G1/S transition of mitotic cell cycle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    cell division IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to DNA damage stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to insulin stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    centriole replication ISO
    Inferred from Sequence Orthology
    more info
     
    histone phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    meiotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of transcription by RNA polymerase II IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    peptidyl-serine phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    peptidyl-serine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of DNA-dependent DNA replication initiation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of cell proliferation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of cell proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription, DNA-templated IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    potassium ion transport IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    protein phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of G2/M transition of mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    regulation of cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of gene silencing ISO
    Inferred from Sequence Orthology
    more info
     
    response to cAMP ISO
    Inferred from Sequence Orthology
    more info
     
    response to electrical stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    Cajal body ISO
    Inferred from Sequence Orthology
    more info
     
    X chromosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Y chromosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    centrosome ISO
    Inferred from Sequence Orthology
    more info
     
    chromosome, telomeric region IDA
    Inferred from Direct Assay
    more info
    PubMed 
    condensed chromosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cyclin A1-CDK2 complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cyclin A1-CDK2 complex ISO
    Inferred from Sequence Orthology
    more info
     
    cyclin A2-CDK2 complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cyclin A2-CDK2 complex ISO
    Inferred from Sequence Orthology
    more info
     
    cyclin E1-CDK2 complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cyclin E1-CDK2 complex ISO
    Inferred from Sequence Orthology
    more info
     
    cyclin E2-CDK2 complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cyclin E2-CDK2 complex ISO
    Inferred from Sequence Orthology
    more info
     
    cyclin-dependent protein kinase holoenzyme complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cyclin-dependent protein kinase holoenzyme complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    cyclin-dependent protein kinase holoenzyme complex ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    endosome ISO
    Inferred from Sequence Orthology
    more info
     
    intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    transcription factor complex IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    cyclin-dependent kinase 2
    Names
    cell division protein kinase 2
    NP_058036.1
    NP_904326.1
    XP_006513225.1
    XP_011241623.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_016756.4NP_058036.1  cyclin-dependent kinase 2 isoform 2

      See identical proteins and their annotated locations for NP_058036.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame coding exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AK152922, CN705407
      Consensus CDS
      CCDS24288.1
      UniProtKB/Swiss-Prot
      P97377
      UniProtKB/TrEMBL
      Q3U6X7
      Related
      ENSMUSP00000026415.7, ENSMUST00000026415.8
      Conserved Domains (1) summary
      cd07860
      Location:3286
      STKc_CDK2_3; Catalytic domain of the Serine/Threonine Kinases, Cyclin-Dependent protein Kinase 2 and 3
    2. NM_183417.3NP_904326.1  cyclin-dependent kinase 2 isoform 1

      See identical proteins and their annotated locations for NP_904326.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK148017, AK151979, AK152922, CN705407
      Consensus CDS
      CCDS24289.1
      UniProtKB/Swiss-Prot
      P97377
      UniProtKB/TrEMBL
      Q3U6X7, Q3UGB9
      Related
      ENSMUSP00000026416.7, ENSMUST00000026416.14
      Conserved Domains (1) summary
      cd07860
      Location:3334
      STKc_CDK2_3; Catalytic domain of the Serine/Threonine Kinases, Cyclin-Dependent protein Kinase 2 and 3

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000076.6 Reference GRCm38.p4 C57BL/6J

      Range
      128697939..128705051 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011243321.2XP_011241623.1  cyclin-dependent kinase 2 isoform X1

      See identical proteins and their annotated locations for XP_011241623.1

      Conserved Domains (1) summary
      cl21453
      Location:1244
      PKc_like; Protein Kinases, catalytic domain
    2. XM_006513162.2XP_006513225.1  cyclin-dependent kinase 2 isoform X1

      See identical proteins and their annotated locations for XP_006513225.1

      Conserved Domains (1) summary
      cl21453
      Location:1244
      PKc_like; Protein Kinases, catalytic domain
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