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    Cdc7 cell division cycle 7 (S. cerevisiae) [ Mus musculus (house mouse) ]

    Gene ID: 12545, updated on 31-Jan-2019

    Summary

    Official Symbol
    Cdc7provided by MGI
    Official Full Name
    cell division cycle 7 (S. cerevisiae)provided by MGI
    Primary source
    MGI:MGI:1309511
    See related
    Ensembl:ENSMUSG00000029283
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Cdc7l1; muCdc7; AI597260
    Expression
    Broad expression in CNS E11.5 (RPKM 17.6), limb E14.5 (RPKM 17.1) and 19 other tissues See more
    Orthologs

    Genomic context

    See Cdc7 in Genome Data Viewer
    Location:
    5; 5 E5
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 5 NC_000071.6 (106964315..106984440)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (107393341..107413450)

    Chromosome 5 - NC_000071.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 33327 Neighboring gene HFM1, ATP-dependent DNA helicase homolog Neighboring gene olfactory receptor 719, pseudogene Neighboring gene predicted gene, 33371 Neighboring gene predicted gene, 33474

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC91067

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    cell cycle phase transition ISO
    Inferred from Sequence Orthology
    more info
     
    cell division IEA
    Inferred from Electronic Annotation
    more info
     
    double-strand break repair via break-induced replication IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    peptidyl-serine phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    peptidyl-threonine phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of G2/M transition of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of nuclear cell cycle DNA replication ISO
    Inferred from Sequence Orthology
    more info
     
    protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    intercellular bridge ISO
    Inferred from Sequence Orthology
    more info
     
    mitotic spindle ISO
    Inferred from Sequence Orthology
    more info
     
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    cell division cycle 7-related protein kinase
    Names
    CDC7-related kinase
    cell division cycle 7-like 1
    NP_001258495.1
    NP_001258496.1
    NP_001258497.1
    NP_033993.2
    XP_006534800.1
    XP_017176123.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001271566.1NP_001258495.1  cell division cycle 7-related protein kinase isoform 1

      See identical proteins and their annotated locations for NP_001258495.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). Both variants 1 and 2 encode the same isoform (1).
      Source sequence(s)
      AC134409, AK145921, AK146009
      Consensus CDS
      CCDS19498.1
      UniProtKB/Swiss-Prot
      Q9Z0H0
      Related
      ENSMUSP00000113385.1, ENSMUST00000118261.7
      Conserved Domains (2) summary
      cd14019
      Location:50429
      STKc_Cdc7; Catalytic domain of the Serine/Threonine Kinase, Cell Division Cycle 7 kinase
      cl21453
      Location:337559
      PKc_like; Protein Kinases, catalytic domain
    2. NM_001271567.1NP_001258496.1  cell division cycle 7-related protein kinase isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and lacks an alternate in-frame exon in the coding region compared to variant 1. It encodes isoform 2, which is shorter than isoform (1).
      Source sequence(s)
      AC134409
      Consensus CDS
      CCDS71628.1
      UniProtKB/Swiss-Prot
      Q9Z0H0
      Related
      ENSMUSP00000112392.2, ENSMUST00000117196.8
      Conserved Domains (3) summary
      smart00220
      Location:52388
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14019
      Location:50397
      STKc_Cdc7; Catalytic domain of the Serine/Threonine Kinase, Cell Division Cycle 7 kinase
      cl21453
      Location:305527
      PKc_like; Protein Kinases, catalytic domain
    3. NM_001271568.1NP_001258497.1  cell division cycle 7-related protein kinase isoform 3

      See identical proteins and their annotated locations for NP_001258497.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR, lacks an alternate in-frame exon and uses an alternate in-frame acceptor splice site in the coding region compared to variant 1. It encodes isoform 3, which is shorter than isoform (1).
      Source sequence(s)
      AC134409, BC072666, BC080702
      Consensus CDS
      CCDS71629.1
      UniProtKB/Swiss-Prot
      Q9Z0H0
      UniProtKB/TrEMBL
      Q66JY4
      Related
      ENSMUSP00000075792.6, ENSMUST00000076467.12
      Conserved Domains (1) summary
      cd14019
      Location:50390
      STKc_Cdc7; Catalytic domain of the Serine/Threonine Kinase, Cell Division Cycle 7 kinase
    4. NM_009863.3NP_033993.2  cell division cycle 7-related protein kinase isoform 1

      See identical proteins and their annotated locations for NP_033993.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same isoform (1).
      Source sequence(s)
      AC134409, AK145921
      Consensus CDS
      CCDS19498.1
      UniProtKB/Swiss-Prot
      Q9Z0H0
      Related
      ENSMUSP00000031221.5, ENSMUST00000031221.11
      Conserved Domains (2) summary
      cd14019
      Location:50429
      STKc_Cdc7; Catalytic domain of the Serine/Threonine Kinase, Cell Division Cycle 7 kinase
      cl21453
      Location:337559
      PKc_like; Protein Kinases, catalytic domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000071.6 Reference GRCm38.p4 C57BL/6J

      Range
      106964315..106984440
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006534737.2XP_006534800.1  cell division cycle 7-related protein kinase isoform X1

      Conserved Domains (1) summary
      cl21453
      Location:50201
      PKc_like; Protein Kinases, catalytic domain
    2. XM_017320634.1XP_017176123.1  cell division cycle 7-related protein kinase isoform X2

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