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    Cdc45 cell division cycle 45 [ Mus musculus (house mouse) ]

    Gene ID: 12544, updated on 31-Jan-2019

    Summary

    Official Symbol
    Cdc45provided by MGI
    Official Full Name
    cell division cycle 45provided by MGI
    Primary source
    MGI:MGI:1338073
    See related
    Ensembl:ENSMUSG00000000028
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Cdc45l
    Expression
    Broad expression in liver E14.5 (RPKM 24.8), liver E14 (RPKM 24.1) and 20 other tissues See more
    Orthologs

    Genomic context

    See Cdc45 in Genome Data Viewer
    Location:
    16 A3; 16 11.63 cM
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 16 NC_000082.6 (18780447..18811992, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 16 NC_000082.5 (18780540..18812065, complement)

    Chromosome 16 - NC_000082.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 41428 Neighboring gene claudin 5 Neighboring gene ubiquitin recognition factor in ER-associated degradation 1 Neighboring gene RIKEN cDNA 2510002D24 gene Neighboring gene mitochondrial ribosomal protein L40

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Targeted (1)  1 citation
    • Endonuclease-mediated (1) 

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    3'-5' DNA helicase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    DNA replication origin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    chromatin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    single-stranded DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    DNA replication IEA
    Inferred from Electronic Annotation
    more info
     
    DNA replication initiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    double-strand break repair via break-induced replication IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    mitotic DNA replication preinitiation complex assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of G1/S transition of mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    regulation of chromatin silencing at telomere IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    DNA replication preinitiation complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    centrosome ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear pre-replicative complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    replication fork protection complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    cell division control protein 45 homolog
    Names
    CDC45-related protein
    PORC-PI-1
    cell division cycle 45 homolog

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001161623.2NP_001155095.1  cell division control protein 45 homolog isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an in-frame exon in the 5' coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
      Source sequence(s)
      AC083895
      Consensus CDS
      CCDS49788.1
      UniProtKB/Swiss-Prot
      Q9Z1X9
      UniProtKB/TrEMBL
      F8WJ72
      Related
      ENSMUSP00000094753.3, ENSMUST00000096990.9
      Conserved Domains (1) summary
      pfam02724
      Location:19515
      CDC45; CDC45-like protein
    2. NM_001358206.1NP_001345135.1  cell division control protein 45 homolog isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Both variants 1 and 3 encode the same protein.
      Source sequence(s)
      AC083895
      Conserved Domains (1) summary
      pfam02724
      Location:19561
      CDC45; CDC45-like protein
    3. NM_009862.2NP_033992.2  cell division control protein 45 homolog isoform 1

      See identical proteins and their annotated locations for NP_033992.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1). Both variants 1 and 3 encode the same protein.
      Source sequence(s)
      AF081536, BC028635, CO040149
      Consensus CDS
      CCDS28027.1
      UniProtKB/Swiss-Prot
      Q9Z1X9
      UniProtKB/TrEMBL
      Q3UI99
      Related
      ENSMUSP00000000028.7, ENSMUST00000000028.13
      Conserved Domains (1) summary
      pfam02724
      Location:19561
      CDC45; CDC45-like protein

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000082.6 Reference GRCm38.p4 C57BL/6J

      Range
      18780447..18811992 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011245813.2XP_011244115.1  cell division control protein 45 homolog isoform X1

      UniProtKB/Swiss-Prot
      Q9Z1X9
      UniProtKB/TrEMBL
      Q3UI99
      Conserved Domains (1) summary
      pfam02724
      Location:19561
      CDC45; CDC45-like protein
    2. XM_006521744.2XP_006521807.1  cell division control protein 45 homolog isoform X1

      See identical proteins and their annotated locations for XP_006521807.1

      UniProtKB/Swiss-Prot
      Q9Z1X9
      UniProtKB/TrEMBL
      Q3UI99
      Conserved Domains (1) summary
      pfam02724
      Location:19561
      CDC45; CDC45-like protein

    Reference GRCm38.p4 129S1/SvImJ

    Genomic

    1. NT_187008.1 Reference GRCm38.p4 129S1/SvImJ

      Range
      84119..115652 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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