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    Cdc37 cell division cycle 37 [ Mus musculus (house mouse) ]

    Gene ID: 12539, updated on 3-Feb-2019

    Summary

    Official Symbol
    Cdc37provided by MGI
    Official Full Name
    cell division cycle 37provided by MGI
    Primary source
    MGI:MGI:109531
    See related
    Ensembl:ENSMUSG00000019471
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    p50; p50Cdc37
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 68.6), liver E14 (RPKM 50.3) and 28 other tissues See more
    Orthologs

    Genomic context

    See Cdc37 in Genome Data Viewer
    Location:
    9; 9 A3
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 9 NC_000075.6 (21138541..21149977, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 9 NC_000075.5 (20942985..20954350, complement)

    Chromosome 9 - NC_000075.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 38431 Neighboring gene ribonucleoprotein, PTB-binding 1 Neighboring gene microRNA 7082 Neighboring gene tyrosine kinase 2 Neighboring gene predicted gene, 35977 Neighboring gene predicted gene, 39301 Neighboring gene predicted gene, 36118

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    Hsp90 protein binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    chaperone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    chaperone binding ISO
    Inferred from Sequence Orthology
    more info
     
    heat shock protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    heat shock protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    mitogen-activated protein kinase kinase kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein C-terminus binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein kinase B binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    contributes_to protein kinase regulator activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    scaffold protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    unfolded protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    HSP90-CDC37 chaperone complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    HSP90-CDC37 chaperone complex ISO
    Inferred from Sequence Orthology
    more info
     
    chaperone complex ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     
    ruffle membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    hsp90 co-chaperone Cdc37
    Names
    cell division cycle 37 homolog
    hsp90 chaperone protein kinase-targeting subunit

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_016742.4NP_058022.1  hsp90 co-chaperone Cdc37

      See identical proteins and their annotated locations for NP_058022.1

      Status: PROVISIONAL

      Source sequence(s)
      AC163637
      Consensus CDS
      CCDS22894.1
      UniProtKB/Swiss-Prot
      Q61081
      Related
      ENSMUSP00000019615.9, ENSMUST00000019615.10
      Conserved Domains (3) summary
      smart01071
      Location:1128
      CDC37_N; Cdc37 N terminal kinase binding
      smart01069
      Location:288378
      CDC37_C; Cdc37 C terminal domain
      smart01070
      Location:134276
      CDC37_M; Cdc37 Hsp90 binding domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000075.6 Reference GRCm38.p4 C57BL/6J

      Range
      21138541..21149977 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006509967.1XP_006510030.1  hsp90 co-chaperone Cdc37 isoform X1

      See identical proteins and their annotated locations for XP_006510030.1

      Related
      ENSMUSP00000150265.1, ENSMUST00000215296.1
      Conserved Domains (3) summary
      smart01071
      Location:1127
      CDC37_N; Cdc37 N terminal kinase binding
      smart01069
      Location:337427
      CDC37_C; Cdc37 C terminal domain
      smart01070
      Location:183325
      CDC37_M; Cdc37 Hsp90 binding domain
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