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    Cdk11b cyclin dependent kinase 11B [ Mus musculus (house mouse) ]

    Gene ID: 12537, updated on 10-Oct-2024

    Summary

    Official Symbol
    Cdk11bprovided by MGI
    Official Full Name
    cyclin dependent kinase 11Bprovided by MGI
    Primary source
    MGI:MGI:88353
    See related
    Ensembl:ENSMUSG00000029062 AllianceGenome:MGI:88353
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    p58; Cdk11; Cdc11b; Cdc2l1; Cdc2l2; CDK11-p46; CDK11-p58; CDK11-p110
    Summary
    Predicted to enable ATP binding activity and cyclin-dependent protein serine/threonine kinase activity. Acts upstream of or within blastocyst development; negative regulation of apoptotic signaling pathway; and regulation of mitotic nuclear division. Located in nucleus. Is expressed in several structures, including alimentary system; blastocyst; brain; early embryo; and integumental system. Orthologous to several human genes including CDK11B (cyclin dependent kinase 11B). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 24.0), large intestine adult (RPKM 15.5) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Cdk11b in Genome Data Viewer
    Location:
    4 E2; 4 86.73 cM
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (155709303..155734392)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (155624841..155649935)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E340 Neighboring gene STARR-positive B cell enhancer ABC_E10296 Neighboring gene NAD kinase Neighboring gene STARR-positive B cell enhancer ABC_E3559 Neighboring gene solute carrier family 35, member E2 Neighboring gene predicted gene 16023 Neighboring gene matrix metallopeptidase 23 Neighboring gene STARR-seq mESC enhancer starr_12269 Neighboring gene mindbomb E3 ubiquitin protein ligase 2 Neighboring gene STARR-seq mESC enhancer starr_12270 Neighboring gene STARR-seq mESC enhancer starr_12271 Neighboring gene fibronectin type III domain containing 10

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables cyclin-dependent protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    part_of cyclin-dependent protein kinase holoenzyme complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of cyclin-dependent protein kinase holoenzyme complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    cyclin-dependent kinase 11B
    Names
    PITSLRE proteins
    PITSLRE serine/threonine-protein kinase CDC2L1
    cell division cycle 2 homolog-like 1
    cell division cycle 2 homolog-like 2
    cell division cycle 2-like 1
    cell division cycle 2-like 2
    cell division cycle 2-like protein kinase 1
    cell division protein kinase 11
    cyclin-dependent kinase 11
    galactosyltransferase-associated protein kinase p58/GTA
    NP_001334237.1
    NP_001342496.1
    NP_001342497.1
    NP_001342498.1
    NP_001406922.1
    NP_001406923.1
    NP_001406924.1
    NP_001406925.1
    NP_001406926.1
    NP_001406927.1
    NP_001406928.1
    NP_001406929.1
    NP_031687.2
    XP_036019504.1
    XP_036019506.1
    XP_036019507.1
    XP_036019509.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001347308.2NP_001334237.1  cyclin-dependent kinase 11B isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL627405
      Consensus CDS
      CCDS84837.1
      UniProtKB/TrEMBL
      A2A9P6
      Conserved Domains (1) summary
      cd07843
      Location:387678
      STKc_CDC2L1; Catalytic domain of the Serine/Threonine Kinase, Cell Division Cycle 2-like 1
    2. NM_001355567.2NP_001342496.1  cyclin-dependent kinase 11B isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL627405
      Conserved Domains (1) summary
      cd07843
      Location:420711
      STKc_CDC2L1; Catalytic domain of the Serine/Threonine Kinase, Cell Division Cycle 2-like 1
    3. NM_001355568.2NP_001342497.1  cyclin-dependent kinase 11B isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL627405
      Consensus CDS
      CCDS84837.1
      UniProtKB/TrEMBL
      A2A9P6
      Related
      ENSMUSP00000101223.2, ENSMUST00000105598.2
      Conserved Domains (1) summary
      cd07843
      Location:387678
      STKc_CDC2L1; Catalytic domain of the Serine/Threonine Kinase, Cell Division Cycle 2-like 1
    4. NM_001355569.2NP_001342498.1  cyclin-dependent kinase 11B isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL627405
      UniProtKB/TrEMBL
      Q8R190
      Conserved Domains (1) summary
      cd07843
      Location:76367
      STKc_CDC2L1; Catalytic domain of the Serine/Threonine Kinase, Cell Division Cycle 2-like 1
    5. NM_001419993.1NP_001406922.1  cyclin-dependent kinase 11B isoform 5

      Status: VALIDATED

      Source sequence(s)
      AL627405
    6. NM_001419994.1NP_001406923.1  cyclin-dependent kinase 11B isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL627405
      UniProtKB/Swiss-Prot
      P24788, Q3UI03, Q61399, Q7TST4, Q8BP53
      Related
      ENSMUSP00000101225.2, ENSMUST00000105600.8
    7. NM_001419995.1NP_001406924.1  cyclin-dependent kinase 11B isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL627405
      UniProtKB/TrEMBL
      A2A9P6
    8. NM_001419996.1NP_001406925.1  cyclin-dependent kinase 11B isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL627405
      UniProtKB/TrEMBL
      A2A9P6
    9. NM_001419997.1NP_001406926.1  cyclin-dependent kinase 11B isoform 5

      Status: VALIDATED

      Source sequence(s)
      AL627405
    10. NM_001419998.1NP_001406927.1  cyclin-dependent kinase 11B isoform 6

      Status: VALIDATED

      Source sequence(s)
      AL627405
    11. NM_001419999.1NP_001406928.1  cyclin-dependent kinase 11B isoform 6

      Status: VALIDATED

      Source sequence(s)
      AL627405
    12. NM_001420000.1NP_001406929.1  cyclin-dependent kinase 11B isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL627405
    13. NM_007661.5NP_031687.2  cyclin-dependent kinase 11B isoform 1

      See identical proteins and their annotated locations for NP_031687.2

      Status: VALIDATED

      Source sequence(s)
      AL627405
      Consensus CDS
      CCDS19033.1
      UniProtKB/Swiss-Prot
      P24788, Q3UI03, Q61399, Q7TST4, Q8BP53
      Related
      ENSMUSP00000070527.4, ENSMUST00000067081.10
      Conserved Domains (1) summary
      cd07843
      Location:421712
      STKc_CDC2L1; Catalytic domain of the Serine/Threonine Kinase, Cell Division Cycle 2-like 1

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      155709303..155734392
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036163611.1XP_036019504.1  cyclin-dependent kinase 11B isoform X4

      Conserved Domains (1) summary
      cd07843
      Location:204495
      STKc_CDC2L1; Catalytic domain of the Serine/Threonine Kinase, Cell Division Cycle 2-like 1
    2. XM_036163614.1XP_036019507.1  cyclin-dependent kinase 11B isoform X4

      Conserved Domains (1) summary
      cd07843
      Location:204495
      STKc_CDC2L1; Catalytic domain of the Serine/Threonine Kinase, Cell Division Cycle 2-like 1
    3. XM_036163613.1XP_036019506.1  cyclin-dependent kinase 11B isoform X4

      Conserved Domains (1) summary
      cd07843
      Location:204495
      STKc_CDC2L1; Catalytic domain of the Serine/Threonine Kinase, Cell Division Cycle 2-like 1
    4. XM_036163616.1XP_036019509.1  cyclin-dependent kinase 11B isoform X5

      UniProtKB/TrEMBL
      Q8R190
      Conserved Domains (1) summary
      cd07843
      Location:76367
      STKc_CDC2L1; Catalytic domain of the Serine/Threonine Kinase, Cell Division Cycle 2-like 1

    RNA

    1. XR_004941802.1 RNA Sequence

    2. XR_004941803.1 RNA Sequence

    3. XR_004941804.1 RNA Sequence