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    Cdk11b cyclin dependent kinase 11B [ Mus musculus (house mouse) ]

    Gene ID: 12537, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Cdk11bprovided by MGI
    Official Full Name
    cyclin dependent kinase 11Bprovided by MGI
    Primary source
    MGI:MGI:88353
    See related
    Ensembl:ENSMUSG00000029062 AllianceGenome:MGI:88353
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    p58; Cdk11; Cdc11b; Cdc2l1; Cdc2l2; CDK11-p46; CDK11-p58; CDK11-p110
    Summary
    Predicted to enable ATP binding activity and cyclin-dependent protein serine/threonine kinase activity. Acts upstream of or within blastocyst development; negative regulation of apoptotic signaling pathway; and regulation of mitotic nuclear division. Located in nucleus. Is expressed in several structures, including alimentary system; blastocyst; brain; early embryo; and integumental system. Orthologous to several human genes including CDK11B (cyclin dependent kinase 11B). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 24.0), large intestine adult (RPKM 15.5) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    4 E2; 4 86.73 cM
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (155709303..155734392)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (155624841..155649935)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E340 Neighboring gene STARR-positive B cell enhancer ABC_E10296 Neighboring gene NAD kinase Neighboring gene STARR-positive B cell enhancer ABC_E3559 Neighboring gene solute carrier family 35, member E2 Neighboring gene predicted gene 16023 Neighboring gene matrix metallopeptidase 23 Neighboring gene STARR-seq mESC enhancer starr_12269 Neighboring gene mindbomb E3 ubiquitin protein ligase 2 Neighboring gene STARR-seq mESC enhancer starr_12270 Neighboring gene STARR-seq mESC enhancer starr_12271 Neighboring gene fibronectin type III domain containing 10

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. CDK11p58 Promotes Microglia Activation via Inducing Cyclin D3 Nuclear Localization. Shen B, et al. Inflammation, 2017 Apr. PMID 28101846
    2. A cyclin-dependent kinase homologue, p130PITSLRE is a phosphotyrosine-independent SH2 ligand. Malek SN, et al. J Biol Chem, 1994 Dec 30. PMID 7528743
    3. Regulated expression of a cell division control-related protein kinase during development. Kidd VJ, et al. Cell Growth Differ, 1991 Feb. PMID 2069872
    4. CDK11 Promotes Cytokine-Induced Apoptosis in Pancreatic Beta Cells Independently of Glucose Concentration and Is Regulated by Inflammation in the NOD Mouse Model. Sala E, et al. Front Immunol, 2021. PMID 33664748, Free PMC Article
    5. Haploinsufficiency of the cdc2l gene contributes to skin cancer development in mice. Chandramouli A, et al. Carcinogenesis, 2007 Sep. PMID 17389615

    See all (41) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CDK11 Promotes Cytokine-Induced Apoptosis in Pancreatic Beta Cells Independently of Glucose Concentration and Is Regulated by Inflammation in the NOD Mouse Model.
      Title: CDK11 Promotes Cytokine-Induced Apoptosis in Pancreatic Beta Cells Independently of Glucose Concentration and Is Regulated by Inflammation in the NOD Mouse Model.
    2. suggested that CDK11p58 acted to regulate microglia activation through CDK11p58 and cyclin D3 interaction
      Title: CDK11p58 Promotes Microglia Activation via Inducing Cyclin D3 Nuclear Localization.
    3. These data suggest that cyclin D3/CDK11p58 signaling is involved in the negative regulation of AR function.
      Title: Cyclin D3/CDK11p58 complex is involved in the repression of androgen receptor.
    4. Cdc2l1 is a previously unrecognized member of the Hh signal transduction cascade.
      Title: Kinome siRNA screen identifies regulators of ciliogenesis and hedgehog signal transduction.
    5. CDK11(p58) is expressed in proliferating germ cells in the early stages of developing testes
      Title: Protein expression pattern of CDK11(p58) during testicular development in the mouse.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables cyclin-dependent protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within blastocyst development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within mitotic sister chromatid cohesion, centromeric ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of apoptotic signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of apoptotic process NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of cell cycle NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of centrosome cycle NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of mitotic nuclear division IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of cyclin-dependent protein kinase holoenzyme complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    cyclin-dependent kinase 11B
    Names
    PITSLRE proteins
    PITSLRE serine/threonine-protein kinase CDC2L1
    cell division cycle 2 homolog-like 1
    cell division cycle 2 homolog-like 2
    cell division cycle 2-like 1
    cell division cycle 2-like 2
    cell division cycle 2-like protein kinase 1
    cell division protein kinase 11
    cyclin-dependent kinase 11
    galactosyltransferase-associated protein kinase p58/GTA
    NP_001334237.1
    NP_001342496.1
    NP_001342497.1
    NP_001342498.1
    NP_001406922.1
    NP_001406923.1
    NP_001406924.1
    NP_001406925.1
    NP_001406926.1
    NP_001406927.1
    NP_001406928.1
    NP_001406929.1
    NP_031687.2
    XP_036019504.1
    XP_036019506.1
    XP_036019507.1
    XP_036019509.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001347308.2 → NP_001334237.1  cyclin-dependent kinase 11B isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL627405
      Consensus CDS
      CCDS84837.1
      UniProtKB/TrEMBL
      A2A9P6
      Conserved Domains (1) summary
      cd07843
      Location:387 → 678
      STKc_CDC2L1; Catalytic domain of the Serine/Threonine Kinase, Cell Division Cycle 2-like 1

    2. NM_001355567.2 → NP_001342496.1  cyclin-dependent kinase 11B isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL627405
      Conserved Domains (1) summary
      cd07843
      Location:420 → 711
      STKc_CDC2L1; Catalytic domain of the Serine/Threonine Kinase, Cell Division Cycle 2-like 1

    3. NM_001355568.2 → NP_001342497.1  cyclin-dependent kinase 11B isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL627405
      Consensus CDS
      CCDS84837.1
      UniProtKB/TrEMBL
      A2A9P6
      Related
      ENSMUSP00000101223.2, ENSMUST00000105598.2
      Conserved Domains (1) summary
      cd07843
      Location:387 → 678
      STKc_CDC2L1; Catalytic domain of the Serine/Threonine Kinase, Cell Division Cycle 2-like 1

    4. NM_001355569.2 → NP_001342498.1  cyclin-dependent kinase 11B isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL627405
      UniProtKB/TrEMBL
      Q8R190
      Conserved Domains (1) summary
      cd07843
      Location:76 → 367
      STKc_CDC2L1; Catalytic domain of the Serine/Threonine Kinase, Cell Division Cycle 2-like 1

    5. NM_001419993.1 → NP_001406922.1  cyclin-dependent kinase 11B isoform 5

      Status: VALIDATED

      Source sequence(s)
      AL627405

    6. NM_001419994.1 → NP_001406923.1  cyclin-dependent kinase 11B isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL627405
      UniProtKB/Swiss-Prot
      P24788, Q3UI03, Q61399, Q7TST4, Q8BP53

    7. NM_001419995.1 → NP_001406924.1  cyclin-dependent kinase 11B isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL627405
      UniProtKB/TrEMBL
      A2A9P6

    8. NM_001419996.1 → NP_001406925.1  cyclin-dependent kinase 11B isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL627405
      UniProtKB/TrEMBL
      A2A9P6

    9. NM_001419997.1 → NP_001406926.1  cyclin-dependent kinase 11B isoform 5

      Status: VALIDATED

      Source sequence(s)
      AL627405

    10. NM_001419998.1 → NP_001406927.1  cyclin-dependent kinase 11B isoform 6

      Status: VALIDATED

      Source sequence(s)
      AL627405

    11. NM_001419999.1 → NP_001406928.1  cyclin-dependent kinase 11B isoform 6

      Status: VALIDATED

      Source sequence(s)
      AL627405

    12. NM_001420000.1 → NP_001406929.1  cyclin-dependent kinase 11B isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL627405

    13. NM_007661.5 → NP_031687.2  cyclin-dependent kinase 11B isoform 1

      See identical proteins and their annotated locations for NP_031687.2

      Status: VALIDATED

      Source sequence(s)
      AL627405
      Consensus CDS
      CCDS19033.1
      UniProtKB/Swiss-Prot
      P24788, Q3UI03, Q61399, Q7TST4, Q8BP53
      Related
      ENSMUSP00000070527.4, ENSMUST00000067081.10
      Conserved Domains (1) summary
      cd07843
      Location:421 → 712
      STKc_CDC2L1; Catalytic domain of the Serine/Threonine Kinase, Cell Division Cycle 2-like 1

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      155709303..155734392
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036163611.1 → XP_036019504.1  cyclin-dependent kinase 11B isoform X4

      Conserved Domains (1) summary
      cd07843
      Location:204 → 495
      STKc_CDC2L1; Catalytic domain of the Serine/Threonine Kinase, Cell Division Cycle 2-like 1

    2. XM_036163614.1 → XP_036019507.1  cyclin-dependent kinase 11B isoform X4

      Conserved Domains (1) summary
      cd07843
      Location:204 → 495
      STKc_CDC2L1; Catalytic domain of the Serine/Threonine Kinase, Cell Division Cycle 2-like 1

    3. XM_036163613.1 → XP_036019506.1  cyclin-dependent kinase 11B isoform X4

      Conserved Domains (1) summary
      cd07843
      Location:204 → 495
      STKc_CDC2L1; Catalytic domain of the Serine/Threonine Kinase, Cell Division Cycle 2-like 1

    4. XM_036163616.1 → XP_036019509.1  cyclin-dependent kinase 11B isoform X5

      UniProtKB/TrEMBL
      Q8R190
      Conserved Domains (1) summary
      cd07843
      Location:76 → 367
      STKc_CDC2L1; Catalytic domain of the Serine/Threonine Kinase, Cell Division Cycle 2-like 1

    RNA

    1. XR_004941802.1 RNA Sequence

    2. XR_004941803.1 RNA Sequence

    3. XR_004941804.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P24788.2 GenPept UniProtKB/Swiss-Prot:P24788

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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