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    Cdk11b cyclin-dependent kinase 11B [ Mus musculus (house mouse) ]

    Gene ID: 12537, updated on 31-Jan-2019

    Summary

    Official Symbol
    Cdk11bprovided by MGI
    Official Full Name
    cyclin-dependent kinase 11Bprovided by MGI
    Primary source
    MGI:MGI:88353
    See related
    Ensembl:ENSMUSG00000029062
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    p58; Cdk11; Cdc11b; Cdc2l1; Cdc2l2; AA989746; CDK11-p46; CDK11-p58; CDK11-p110
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 24.0), large intestine adult (RPKM 15.5) and 28 other tissues See more
    Orthologs

    Genomic context

    See Cdk11b in Genome Data Viewer
    Location:
    4 E2; 4 86.73 cM
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 4 NC_000070.6 (155624852..155649935)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 4 NC_000070.5 (154998978..155024041)

    Chromosome 4 - NC_000070.6Genomic Context describing neighboring genes Neighboring gene NAD kinase Neighboring gene solute carrier family 35, member E2 Neighboring gene predicted gene 16023 Neighboring gene matrix metallopeptidase 23 Neighboring gene mindbomb E3 ubiquitin protein ligase 2 Neighboring gene fibronectin type III domain containing 10

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATP binding ISO
    Inferred from Sequence Orthology
    more info
     
    cyclin-dependent protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    blastocyst development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of apoptotic signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    protein phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of mRNA processing ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of mitotic nuclear division IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    cyclin-dependent kinase 11B
    Names
    PITSLRE proteins
    PITSLRE serine/threonine-protein kinase CDC2L1
    cell division cycle 2 homolog-like 1
    cell division cycle 2 homolog-like 2
    cell division cycle 2-like 1
    cell division cycle 2-like 2
    cell division cycle 2-like protein kinase 1
    cell division protein kinase 11
    cyclin-dependent kinase 11
    galactosyltransferase-associated protein kinase p58/GTA
    NP_031687.2
    XP_006538571.1
    XP_006538573.1
    XP_006538574.1
    XP_006538575.1
    XP_011248481.1
    XP_017175418.1
    XP_017175419.1
    XP_017175420.1
    XP_017175421.1
    XP_017175422.1
    XP_017175423.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001347308.1NP_001334237.1  cyclin-dependent kinase 11B isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus compared to isoform 1.
      Source sequence(s)
      AL627405
      Consensus CDS
      CCDS84837.1
      UniProtKB/Swiss-Prot
      P24788
      UniProtKB/TrEMBL
      A2A9P6
      Conserved Domains (1) summary
      cd07843
      Location:387678
      STKc_CDC2L1; Catalytic domain of the Serine/Threonine Kinase, Cell Division Cycle 2-like 1
    2. NM_001355567.1NP_001342496.1  cyclin-dependent kinase 11B isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate in-frame splice site in the 5' coding region,compared to variant 1. The encoded isoform (3) has the same N- and C-termini, but is one aa shorter than isoform 1.
      Source sequence(s)
      AA210166, AK077668, AK135402, AL627405
      Conserved Domains (1) summary
      cd07843
      Location:420711
      STKc_CDC2L1; Catalytic domain of the Serine/Threonine Kinase, Cell Division Cycle 2-like 1
    3. NM_001355568.1NP_001342497.1  cyclin-dependent kinase 11B isoform 2

      Status: VALIDATED

      Source sequence(s)
      AA210166, AK077668, AK135402, AL627405, BY739008
      Conserved Domains (1) summary
      cd07843
      Location:387678
      STKc_CDC2L1; Catalytic domain of the Serine/Threonine Kinase, Cell Division Cycle 2-like 1
    4. NM_001355569.1NP_001342498.1  cyclin-dependent kinase 11B isoform 4

      Status: VALIDATED

      Source sequence(s)
      AA210166, AK077668, AK135402, AL627405, BY739008
      Conserved Domains (1) summary
      cd07843
      Location:76367
      STKc_CDC2L1; Catalytic domain of the Serine/Threonine Kinase, Cell Division Cycle 2-like 1
    5. NM_007661.4NP_031687.2  cyclin-dependent kinase 11B isoform 1

      See identical proteins and their annotated locations for NP_031687.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AA210166, AK077668, AK135402, AL627405
      Consensus CDS
      CCDS19033.1
      UniProtKB/Swiss-Prot
      P24788
      Related
      ENSMUSP00000070527.3, ENSMUST00000067081.9
      Conserved Domains (2) summary
      cd07843
      Location:421712
      STKc_CDC2L1; Catalytic domain of the Serine/Threonine Kinase, Cell Division Cycle 2-like 1
      PLN00009
      Location:424714
      PLN00009; cyclin-dependent kinase A; Provisional

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000070.6 Reference GRCm38.p4 C57BL/6J

      Range
      155624852..155649935
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017319929.1XP_017175418.1  cyclin-dependent kinase 11B isoform X2

      UniProtKB/Swiss-Prot
      P24788
      Conserved Domains (1) summary
      cd07843
      Location:420711
      STKc_CDC2L1; Catalytic domain of the Serine/Threonine Kinase, Cell Division Cycle 2-like 1
    2. XM_017319933.1XP_017175422.1  cyclin-dependent kinase 11B isoform X6

      UniProtKB/Swiss-Prot
      P24788
      Conserved Domains (1) summary
      cd07843
      Location:76367
      STKc_CDC2L1; Catalytic domain of the Serine/Threonine Kinase, Cell Division Cycle 2-like 1
    3. XM_006538511.2XP_006538574.1  cyclin-dependent kinase 11B isoform X3

      See identical proteins and their annotated locations for XP_006538574.1

      UniProtKB/Swiss-Prot
      P24788
      UniProtKB/TrEMBL
      A2A9P6
      Conserved Domains (1) summary
      cd07843
      Location:387678
      STKc_CDC2L1; Catalytic domain of the Serine/Threonine Kinase, Cell Division Cycle 2-like 1
    4. XM_006538510.2XP_006538573.1  cyclin-dependent kinase 11B isoform X3

      Related
      ENSMUSP00000101223.1, ENSMUST00000105598.1
      Conserved Domains (1) summary
      cd07843
      Location:387678
      STKc_CDC2L1; Catalytic domain of the Serine/Threonine Kinase, Cell Division Cycle 2-like 1
    5. XM_017319930.1XP_017175419.1  cyclin-dependent kinase 11B isoform X3

      UniProtKB/Swiss-Prot
      P24788
      UniProtKB/TrEMBL
      A2A9P6
      Conserved Domains (1) summary
      cd07843
      Location:387678
      STKc_CDC2L1; Catalytic domain of the Serine/Threonine Kinase, Cell Division Cycle 2-like 1
    6. XM_017319931.1XP_017175420.1  cyclin-dependent kinase 11B isoform X4

    7. XM_011250179.2XP_011248481.1  cyclin-dependent kinase 11B isoform X1

      See identical proteins and their annotated locations for XP_011248481.1

      UniProtKB/Swiss-Prot
      P24788
      Related
      ENSMUSP00000101225.1, ENSMUST00000105600.7
      Conserved Domains (2) summary
      cd07843
      Location:421712
      STKc_CDC2L1; Catalytic domain of the Serine/Threonine Kinase, Cell Division Cycle 2-like 1
      PLN00009
      Location:424714
      PLN00009; cyclin-dependent kinase A; Provisional
    8. XM_006538508.2XP_006538571.1  cyclin-dependent kinase 11B isoform X2

      See identical proteins and their annotated locations for XP_006538571.1

      UniProtKB/Swiss-Prot
      P24788
      Conserved Domains (1) summary
      cd07843
      Location:420711
      STKc_CDC2L1; Catalytic domain of the Serine/Threonine Kinase, Cell Division Cycle 2-like 1
    9. XM_006538512.3XP_006538575.1  cyclin-dependent kinase 11B isoform X5

      See identical proteins and their annotated locations for XP_006538575.1

      Conserved Domains (2) summary
      cd07843
      Location:204495
      STKc_CDC2L1; Catalytic domain of the Serine/Threonine Kinase, Cell Division Cycle 2-like 1
      PLN00009
      Location:207497
      PLN00009; cyclin-dependent kinase A; Provisional
    10. XM_017319932.1XP_017175421.1  cyclin-dependent kinase 11B isoform X5

      Conserved Domains (2) summary
      cd07843
      Location:204495
      STKc_CDC2L1; Catalytic domain of the Serine/Threonine Kinase, Cell Division Cycle 2-like 1
      PLN00009
      Location:207497
      PLN00009; cyclin-dependent kinase A; Provisional
    11. XM_017319934.1XP_017175423.1  cyclin-dependent kinase 11B isoform X6

      UniProtKB/Swiss-Prot
      P24788
      Conserved Domains (1) summary
      cd07843
      Location:76367
      STKc_CDC2L1; Catalytic domain of the Serine/Threonine Kinase, Cell Division Cycle 2-like 1

    RNA

    1. XR_001784084.1 RNA Sequence

    2. XR_001784083.1 RNA Sequence

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