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    Cdc25b cell division cycle 25B [ Mus musculus (house mouse) ]

    Gene ID: 12531, updated on 23-Jun-2021

    Summary

    Official Symbol
    Cdc25bprovided by MGI
    Official Full Name
    cell division cycle 25Bprovided by MGI
    Primary source
    MGI:MGI:99701
    See related
    Ensembl:ENSMUSG00000027330
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AI604853
    Expression
    Broad expression in liver E14.5 (RPKM 81.1), liver E14 (RPKM 67.6) and 22 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Cdc25b in Genome Data Viewer
    Location:
    2 F1; 2 63.29 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (131028356..131040431)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (131186436..131198511)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (131012687..131024233)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene sperm flagellar 1 Neighboring gene centromere protein B Neighboring gene adaptor-related protein 5 complex, sigma 1 subunit Neighboring gene mitochondrial antiviral signaling protein

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables phosphoprotein phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein tyrosine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in G2/M transition of mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within cell division IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within female meiosis I IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within oocyte maturation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of G2/M transition of mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in positive regulation of G2/MI transition of meiotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in positive regulation of cell cycle G2/M phase transition IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of cytokinesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of protein kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein dephosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in spindle pole ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    M-phase inducer phosphatase 2
    Names
    dual specificity phosphatase Cdc25B
    NP_001104545.1
    NP_075606.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001111075.4NP_001104545.1  M-phase inducer phosphatase 2 isoform b

      See identical proteins and their annotated locations for NP_001104545.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame coding exon and uses an alternate in-frame splice site compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.
      Source sequence(s)
      AL808128, AL831736, BC057568
      Consensus CDS
      CCDS50717.1
      UniProtKB/TrEMBL
      Q9DBN8
      Related
      ENSMUSP00000078784.9, ENSMUST00000079857.9
      Conserved Domains (2) summary
      cd01530
      Location:382501
      Cdc25; Cdc25 phosphatases are members of the Rhodanese Homology Domain superfamily. They activate the cell division kinases throughout the cell cycle progression. Cdc25 phosphatases dephosphorylate phosphotyrosine and phosphothreonine residues, in order to ...
      pfam06617
      Location:111353
      M-inducer_phosp; M-phase inducer phosphatase
    2. NM_023117.4NP_075606.1  M-phase inducer phosphatase 2 isoform a

      See identical proteins and their annotated locations for NP_075606.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
      Source sequence(s)
      AL808128, AL831736, BC057568, BQ561430, W54021
      Consensus CDS
      CCDS16758.1
      UniProtKB/Swiss-Prot
      P30306
      UniProtKB/TrEMBL
      Q3U535, Q9DBN8
      Related
      ENSMUSP00000028804.9, ENSMUST00000028804.15
      Conserved Domains (2) summary
      cd01530
      Location:408527
      Cdc25; Cdc25 phosphatases are members of the Rhodanese Homology Domain superfamily. They activate the cell division kinases throughout the cell cycle progression. Cdc25 phosphatases dephosphorylate phosphotyrosine and phosphothreonine residues, in order to ...
      pfam06617
      Location:111379
      M-inducer_phosp; M-phase inducer phosphatase

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      131028356..131040431
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_374398.2 RNA Sequence

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